{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:24:56Z","timestamp":1772807096020,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,4,29]],"date-time":"2012-04-29T00:00:00Z","timestamp":1335657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,6]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Biliary colic is a common manifestation of cholelithiasis, developing in about one\u2010third of patients. Even if nonsteroid anti\u2010inflammatory drugs (\n NSAIDs<\/jats:styled-content>\n ) have widely been used to relieve biliary pain, there is a lack of systematic review of treatments on this issue.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To assess the potential benefits in terms of both pain control and reduction of complications, and the potential harms of\n NSAIDs<\/jats:styled-content>\n in patients with biliary colic.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Data from randomised clinical trials (\n RCTs<\/jats:styled-content>\n ) comparing\n NSAIDs<\/jats:styled-content>\n with no treatment, placebo or other drugs in patients with biliary colic, were collected from Medline and Embase. The outcome measures were expressed as odds ratio and relative risk and then pooled using fixed or random\u2010effect models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eleven\n RCTs<\/jats:styled-content>\n involving 1076 subjects (268 men, 808 women; 18\u201386\u00a0years), including 442 controls were analysed. In comparison with placebo,\n NSAIDs<\/jats:styled-content>\n led to a significantly higher proportion of patients with complete pain relief (\n RR<\/jats:styled-content>\n 3.77, 95%\n CI<\/jats:styled-content>\n 1.65\u20138.61;\n I<\/jats:italic>\n 2<\/jats:sup>\n : 73%) and a significantly lower rate of complications (\n RR<\/jats:styled-content>\n 0.53, 95%\n CI<\/jats:styled-content>\n 0.31\u20130.89;\n I<\/jats:italic>\n 2<\/jats:sup>\n : 35%). In comparison with other drugs,\n NSAID<\/jats:styled-content>\n s were more efficacious in controlling pain than spasmolytics (\n RR<\/jats:styled-content>\n 1.47, 95%\n CI<\/jats:styled-content>\n 1.03\u20132.10;\n I<\/jats:italic>\n 2<\/jats:sup>\n : 55%); there was no difference between\n NSAIDs<\/jats:styled-content>\n and opioids (\n RR<\/jats:styled-content>\n 1.05, 95%\n CI<\/jats:styled-content>\n 0.82\u20131.33;\n I<\/jats:italic>\n 2<\/jats:sup>\n : 74%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In patients with biliary colic\n NSAIDs<\/jats:styled-content>\n are the first\u2010choice treatments as they control pain with the same efficacy of opioids and significantly reduce the proportion of patients with severe complications. However, the lack of high\u2010quality\n RCTs<\/jats:styled-content>\n and the presence of consistent heterogeneity among studies may partially flaw these results.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05115.x","type":"journal-article","created":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T00:45:21Z","timestamp":1335746721000},"page":"1370-1378","source":"Crossref","is-referenced-by-count":31,"title":["Meta\u2010analysis: nonsteroidal anti\u2010inflammatory drugs in biliary colic"],"prefix":"10.1111","volume":"35","author":[{"given":"A.","family":"Colli","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Ospedale \u201cA. Manzoni\u201d Lecco Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Conte","sequence":"additional","affiliation":[{"name":"Second Division of Gastroenterology IRCCS Fondazione \u201cC\u00e0 Granda\u201d Ospedale Maggiore Policlinico and Postgraduate School of Gastroenterology University of Milan Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Della","family":"Valle","sequence":"additional","affiliation":[{"name":"Second Division of Gastroenterology IRCCS Fondazione \u201cC\u00e0 Granda\u201d Ospedale Maggiore Policlinico and Postgraduate School of Gastroenterology University of Milan Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Sciola","sequence":"additional","affiliation":[{"name":"Department of Hepatology Ospedale \u201cS. Giuseppe\u201d Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fraquelli","sequence":"additional","affiliation":[{"name":"Second Division of Gastroenterology IRCCS Fondazione \u201cC\u00e0 Granda\u201d Ospedale Maggiore Policlinico and Postgraduate School of Gastroenterology University of Milan Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"249","article-title":"Ten\u2010year incidence and natural history of gallstone disease in a rural population of women in central Italy. 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