{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:14:12Z","timestamp":1787606052759,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T00:00:00Z","timestamp":1337126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,7]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n The use of proton pump inhibitors for prevention of nonsteroidal anti\u2010inflammatory drug (\n NSAID<\/jats:styled-content>\n )\u2010induced gastrointestinal adverse events is well documented. However, data regarding the efficacy and safety of this approach in\n J<\/jats:styled-content>\n apan are scarce.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To evaluate the efficacy and tolerability of esomeprazole in preventing\n NSAID<\/jats:styled-content>\n \u2010induced peptic ulcers in\n J<\/jats:styled-content>\n apanese at\u2010risk patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Male and female\n J<\/jats:styled-content>\n apanese adult patients (aged \u226520\u00a0years) with endoscopically confirmed history of peptic ulcers who required long\u2010term oral\n NSAID<\/jats:styled-content>\n therapy for a chronic inflammatory condition were randomised to 24\u00a0weeks' treatment with esomeprazole 20\u00a0mg once daily or matching placebo. The primary end point was the\n K<\/jats:styled-content>\n aplan\u2013\n M<\/jats:styled-content>\n eier estimated proportion of ulcer\u2010free patients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Overall, 343\u00a0patients were randomised to treatment (esomeprazole,\n n<\/jats:italic>\n \u00a0=\u00a0175; placebo,\n n<\/jats:italic>\n \u00a0=\u00a0168). The\n K<\/jats:styled-content>\n aplan\u2013\n M<\/jats:styled-content>\n eier estimated ulcer\u2010free rate over the 24\u2010week treatment period was significantly higher (log\u2010rank\n P<\/jats:italic>\n \u00a0<\u00a00.001) in esomeprazole\u2010treated patients (96.0%; 95%\n CI<\/jats:styled-content>\n 92.8, 99.1) than in placebo recipients (64.4%; 95%\n CI<\/jats:styled-content>\n 56.8, 71.9). Esomeprazole was effective at preventing peptic ulcers in both\n \n H<\/jats:styled-content>\n elicobacter pylori\n <\/jats:italic>\n \u2010positive and \u2010negative patients (96.3% vs. 95.5% of patients ulcer\u2010free, respectively); however, in the placebo group, the proportion of ulcer\u2010free patients at 24\u00a0weeks was markedly lower among\n \n H<\/jats:styled-content>\n . pylori\n <\/jats:italic>\n \u2010positive than \u2010negative patients (59.7% vs. 69.9%). The\n NSAID<\/jats:styled-content>\n type did not seem to affect the estimated ulcer\u2010free rate with esomeprazole. Treatment with esomeprazole was well tolerated.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Esomeprazole 20\u00a0mg once daily is effective and safe in preventing ulcer recurrence in\n J<\/jats:styled-content>\n apanese patients with a definite history of peptic ulcers who were taking an\n NSAID<\/jats:styled-content>\n (\n ClinicalTrials.gov<\/jats:ext-link>\n identifier:\n NCT<\/jats:styled-content>\n 00542789).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05133.x","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T12:01:25Z","timestamp":1337256085000},"page":"115-125","source":"Crossref","is-referenced-by-count":28,"title":["Randomised clinical trial: esomeprazole for the prevention of nonsteroidal anti\u2010inflammatory drug\u2010related peptic ulcers in\n J<\/scp>\n apanese patients"],"prefix":"10.1111","volume":"36","author":[{"given":"K.","family":"Sugano","sequence":"first","affiliation":[{"name":"Department of Medicine Jichi Medical University Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Shimane University School of Medicine Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hyogo College of Medicine Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Keio University School of Medicine Shinjuku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Esomeprazole NSAID Preventive Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02065549"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32832c7878"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117469"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-5-359"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011233432103"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-10-787"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91843-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.12.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-009-0202-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP47722"},{"key":"e_1_2_6_12_1","first-page":"96","article-title":"Epidemiology study on upper gastrointestinal lesions induced by non\u2010steroidal anti\u2010inflammatory drugs [in Japanese]","volume":"31","author":"Shiokawa Y","year":"1991","journal-title":"Ryumachi"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02476.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23929"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00499.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/11317830-000000000-00000"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2124"},{"key":"e_1_2_6_18_1","first-page":"581","article-title":"Efficacy of direct ELISA kit \u201cE Plate \u2018Eiken\u2019 H. pylori Antibody\u201d on diagnosis of Helicobacter pylori infection [in Japanese]","volume":"43","author":"Kikuchi S","year":"2000","journal-title":"Jpn J Med Pharm Sci"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90482-9"},{"key":"e_1_2_6_20_1","volume-title":"The Errors of Sampling of the Survivorship Tables","author":"Greenwood M","year":"1926"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01312726"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199806000-00001"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0541-z"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04465.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2165\/11534590-000000000-00000"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07273-2"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0171-6"},{"key":"e_1_2_6_28_1","first-page":"213","article-title":"Relationship between the acid\u2010suppression efficacy of proton pump inhibitors and CYP2C19 genetic polymorphism in patients with peptic ulcer","volume":"20","author":"Niu C\u2010Y","year":"2008","journal-title":"Academic Journal of Xi'an Jiaotong University"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04150.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000318746"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.01.007"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.092129"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1098086"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2012.05133.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2012.05133.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T22:56:37Z","timestamp":1698706597000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2012.05133.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,16]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1365-2036.2012.05133.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2012.05133.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717548132.793003146","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717548132.793453704","asserted-by":"object"}]},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,16]]}}}