{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:18:34Z","timestamp":1762521514123},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T00:00:00Z","timestamp":1337644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,7]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Varicella zoster virus (VZV<\/jats:styled-content>) is a severe and preventable infection in immunosuppressed IBD<\/jats:styled-content> patients. ECCO<\/jats:styled-content> guidelines recommend VZV<\/jats:styled-content> immunisation in patients with negative VZV<\/jats:styled-content> exposure history. The value of patient\u2010reported VZV<\/jats:styled-content> exposure history for prediction of seropositivity in IBD<\/jats:styled-content> patients remains unknown. Moreover, data on VZV<\/jats:styled-content> immunity in adult IBD<\/jats:styled-content> patients or accuracy of VZV<\/jats:styled-content> serological testing under immunomodulator treatment is sparse.<\/jats:p><\/jats:sec>Aims<\/jats:title>The primary aim was to determine the prevalence of seropositivity for VZV<\/jats:styled-content>\u2010IgG<\/jats:styled-content> in immunomodulator\u2010treated IBD<\/jats:styled-content> patients. A secondary aim was to establish the value of patient\u2010reported history of past VZV<\/jats:styled-content> infection for prediction of immunity, to validate the current vaccination strategy.<\/jats:p><\/jats:sec>Methods<\/jats:title>History of VZV<\/jats:styled-content>\u2010related illness was accessed by epidemiological questionnaire, and serological testing for VZV<\/jats:styled-content>\u2010IgG<\/jats:styled-content> was performed. Serum anti\u2010TNF<\/jats:styled-content> medications levels were measured when applicable.<\/jats:p><\/jats:sec>Results<\/jats:title>One hundred twenty one IBD<\/jats:styled-content> (86% C<\/jats:styled-content>rohn's disease, mean age 37\u00a0\u00b1\u00a012.8) patients were included in the study. Immunomodulator therapy was received by 87% (anti\u2010TNF<\/jats:styled-content>s\u2010 71%) of the patients. Previous exposure to VZV<\/jats:styled-content> was reported by 104 patients, and 97\/104 (93%) were VZV<\/jats:styled-content>\u2010IgG<\/jats:styled-content> seropositive. Seventeen patients, all seropositive, reported negative exposure history. The calculated positive and negative predictive values for the reported history of VZV<\/jats:styled-content> exposure were 93% and 0% respectively.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Negative history of VZV<\/jats:styled-content> exposure is a poor predictor of seronegativity. History\u2010positive patients may still be seronegative and exposed to VZV<\/jats:styled-content> infection. We suggest serological testing of all IBD<\/jats:styled-content> patients with subsequent immunisation of the seronegative patients before initiation of immunosuppressive therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05150.x","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T04:15:55Z","timestamp":1337660155000},"page":"145-150","source":"Crossref","is-referenced-by-count":35,"title":["Prior varicella zoster virus exposure in IBD<\/scp> patients treated by anti\u2010TNF<\/scp>s and other immunomodulators: implications for serological testing and vaccination guidelines"],"prefix":"10.1111","volume":"36","author":[{"given":"U.","family":"Kopylov","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Levin","sequence":"additional","affiliation":[{"name":"Internal Medicine B Sheba Medical Center Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mendelson","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services Israel Ministry of Health Chaim Sheba Medical Center Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dovrat","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services Israel Ministry of Health Chaim Sheba Medical Center Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Book","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services Israel Ministry of Health Chaim Sheba Medical Center Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Eliakim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ben\u2010Horin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2009.02.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04112.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03612.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.871_w.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0210-5705(01)70132-X"},{"key":"e_1_2_7_7_1","first-page":"19","article-title":"Opportunistic infections in patients with inflammatory bowel disease undergoing immunosuppressive therapy","volume":"26","author":"Bernal I","year":"2003","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/653605"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70312-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.201533"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.04997.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.3.3.365-367.1996"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa064040"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/522145"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053952"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.77294"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05130-11"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-006-6604-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/MPG.0b013e31821e1917","article-title":"Varicella immunity in inflammatory bowel disease","volume":"53","author":"Ansari F","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00646.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2008.08.012"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2012.05150.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2012.05150.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T02:57:01Z","timestamp":1698721021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2012.05150.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,22]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1365-2036.2012.05150.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2012.05150.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,22]]}}}