{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:28:25Z","timestamp":1793219305156,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T00:00:00Z","timestamp":1337817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,7]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>It is believed that women with inflammatory bowel disease (IBD) have heightened symptoms around their menses. However, there is little information regarding normative changes and which symptoms emerge in relation to menses.<\/jats:p><\/jats:sec>Aim<\/jats:title>To determine the relationship between gastrointestinal and other symptoms and menses in a population\u2010based cohort of women with IBD<\/jats:styled-content> vs. healthy women.<\/jats:p><\/jats:sec>Methods<\/jats:title>Women enrolled in the U<\/jats:styled-content>niversity of M<\/jats:styled-content>anitoba IBD R<\/jats:styled-content>esearch R<\/jats:styled-content>egistry who were between 18 and 65\u00a0years were mailed a survey. A control group of adult women were recruited through out\u2010patient gynaecology clinics. Participants were asked to consider their menstrual periods in the recent several months and report on symptoms 1\u20135\u00a0days prior to and during the days of their menses.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 151 premenopausal women with C<\/jats:styled-content>rohn's disease (CD<\/jats:styled-content>), 87 with ulcerative colitis (UC<\/jats:styled-content>) and 156 premenopausal controls. Mean age of menses onset was similar in all three cohorts and the percentage in each group with regular menstrual periods was similar. Premenstrually, abdominal pain was less commonly reported in UC<\/jats:styled-content> (36.8%) than CD<\/jats:styled-content> (51%, P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.034) and controls (57.6%, P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.002). Premenstrually, and during menses diarrhoea was more commonly reported in CD<\/jats:styled-content> (47.7% and 59.6% respectively) than UC<\/jats:styled-content> (26.4% P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.001 and 42.5%, P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.01 respectively) and controls (24.4%, P<\/jats:styled-content><\/jats:italic>\u00a0<\u00a00.0001 and 28.2%, P<\/jats:styled-content><\/jats:italic>\u00a0<\u00a00.0001 respectively). Premenstrually, women with CD<\/jats:styled-content> (46%) vs. UC<\/jats:styled-content> (26%) were more likely to report worsening of their IBD<\/jats:styled-content> symptoms (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.0007), but there was no difference between CD<\/jats:styled-content> (47%) and UC<\/jats:styled-content> (39%) for reporting worsening during menses (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.24).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Compared to healthy women, women with IBD<\/jats:styled-content> had similar symptom experiences premenstrually, except that those with CD<\/jats:styled-content> were more likely to have increased diarrhoea premenstrually. During menses, women with CD<\/jats:styled-content> or UC<\/jats:styled-content> were more likely to experience diarrhoea than healthy controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05155.x","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T11:13:37Z","timestamp":1337858017000},"page":"135-144","source":"Crossref","is-referenced-by-count":39,"title":["Gastrointestinal symptoms before and during menses in women with IBD<\/scp>"],"prefix":"10.1111","volume":"36","author":[{"given":"M. T.","family":"Bernstein","sequence":"first","affiliation":[{"name":"The University of Manitoba IBD Clinical and Research Centre University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"Graff","sequence":"additional","affiliation":[{"name":"The University of Manitoba IBD Clinical and Research Centre University of Manitoba Winnipeg MB Canada"},{"name":"Department of Clinical Health Psychology University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. E.","family":"Targownik","sequence":"additional","affiliation":[{"name":"The University of Manitoba IBD Clinical and Research Centre University of Manitoba Winnipeg MB Canada"},{"name":"Department of Internal Medicine University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Downing","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"Shafer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rawsthorne","sequence":"additional","affiliation":[{"name":"The University of Manitoba IBD Clinical and Research Centre University of Manitoba Winnipeg MB Canada"},{"name":"Department of Internal Medicine University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. N.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"The University of Manitoba IBD Clinical and Research Centre University of Manitoba Winnipeg MB Canada"},{"name":"Department of Internal Medicine University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Avery","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genm.2009.03.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(81)90263-8"},{"key":"e_1_2_6_4_1","first-page":"250","article-title":"Pattern of gastrointestinal and psychosomatic symptoms across the menstrual cycle in women with inflammatory bowel disease","volume":"14","author":"Parlak E","year":"2003","journal-title":"Turk J Gastroenterol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)91079-L"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04409.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/17455057.1.3.299"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2217\/17455057.1.3.401"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.540_i.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10014.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009735"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-11-137"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)03062-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.12.011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01700.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07233.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615600"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2012.05155.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2012.05155.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T02:56:47Z","timestamp":1698721007000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2012.05155.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,24]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1365-2036.2012.05155.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2012.05155.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,24]]}}}