{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:47:18Z","timestamp":1772160438448,"version":"3.50.1"},"reference-count":77,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,6,3]],"date-time":"2012-06-03T00:00:00Z","timestamp":1338681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,7]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Despite similar clinical symptoms, collagenous colitis (\n CC<\/jats:styled-content>\n ) and lymphocytic colitis (\n LC<\/jats:styled-content>\n ) are considered two distinct disease entities.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To compare pathoanatomical findings, clinical presentations, risk factors, course of diseases and response to treatment in\n CC<\/jats:styled-content>\n and\n LC<\/jats:styled-content>\n to establish whether they could be subtypes of the same disease, microscopic colitis (\n MC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The\n MEDLINE<\/jats:styled-content>\n was searched for\n CC<\/jats:styled-content>\n ,\n LC<\/jats:styled-content>\n and\n MC<\/jats:styled-content>\n , and clinical studies of >20 patients were included. Pooled results with 95% confidence intervals were calculated based on the number of patients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n An abnormal number of intraepithelial lymphocytes are found in 45% (40\u201350%) with\n CC<\/jats:styled-content>\n , and an abnormal subepithelial collagen band in 16% (13\u201320%) with\n LC<\/jats:styled-content>\n suggesting a histological overlap. The incidence of\n CC<\/jats:styled-content>\n and\n LC<\/jats:styled-content>\n has increased in parallel. Mean age (\n CC<\/jats:styled-content>\n 63\u00a0years;\n LC<\/jats:styled-content>\n 60\u00a0years) and clinical presentation are indistinguishable, and females are predominant in\n CC<\/jats:styled-content>\n (77%; 75\u201379%) as well as\n LC<\/jats:styled-content>\n (68%; 66\u201370%). Risk factors such as nonsteroid anti\u2010inflammatory drugs consumption\n CC<\/jats:styled-content>\n 39% (36\u201342%);\n LC<\/jats:styled-content>\n 32% (29\u201335%) are similar and prevalence of concomitant autoimmune diseases such as coeliac disease (\n CC<\/jats:styled-content>\n 5%;\n CI<\/jats:styled-content>\n : 4\u20136% and\n LC<\/jats:styled-content>\n 7%;\n CI<\/jats:styled-content>\n : 6\u20139%) do not differ. Bile acid diarrhoea is highly prevalent in\n CC<\/jats:styled-content>\n (41%; 37\u201345%) and\n LC<\/jats:styled-content>\n (29%; 24\u201334%). The effect of budesonide is identical.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n CC<\/jats:styled-content>\n and\n LC<\/jats:styled-content>\n could be considered histological subtypes of the same disease,\n MC<\/jats:styled-content>\n . To facilitate recruitment to clinical trials, all\n MC<\/jats:styled-content>\n patients could be included in future trials and stratified for subtypes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05166.x","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T12:00:48Z","timestamp":1338811248000},"page":"79-90","source":"Crossref","is-referenced-by-count":85,"title":["Systematic review: are lymphocytic colitis and collagenous colitis two subtypes of the same disease \u2010 microscopic colitis?"],"prefix":"10.1111","volume":"36","author":[{"given":"M. A.","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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