{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:28:49Z","timestamp":1792193329430,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,6,3]],"date-time":"2012-06-03T00:00:00Z","timestamp":1338681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The definition of Barrett's oesophagus lacks consensus, particularly the requirement of intestinal metaplasia for diagnosis. Scarce information exists on the prevalence and natural history of columnar\u2010lined oesophagus without intestinal metaplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the demographics and natural history of columnar\u2010lined oesophagus without intestinal metaplasia \u22652\u00a0cm in length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with columnar\u2010lined oesophagus \u22652\u00a0cm in length and no intestinal metaplasia in biopsy specimens from two consecutive endoscopies with at least a 1\u2010year interval were prospectively followed. A cohort of Barrett's oesophagus patients was used as a control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Columnar\u2010lined oesophagus without intestinal metaplasia (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) had a similar gender distribution, reflux symptoms prevalence and length as those of Barrett's oesophagus (<jats:italic>n<\/jats:italic>\u00a0=\u00a0205). Patients were significantly younger (28.6 vs. 60\u00a0years, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and accounted for 48% of patients aged &lt;40\u00a0years in the two cohorts, but only 1% of those aged &gt;40\u00a0years (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Patient distribution in both cohorts in 5 age brackets (0\u201319, 20\u201329, 30\u201339, 40\u201349, and &gt;50\u00a0years) was significantly different, except for patients aged 40\u201349\u00a0years. Intestinal metaplasia was documented in 60% of the cohort after a mean follow\u2010up of 7.1\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Columnar\u2010lined oesophagus without intestinal metaplasia \u22652\u00a0cm is infrequent in the setting of a systematic biopsy protocol, is associated with a younger age in comparison with Barrett's oesophagus, and appears to be an intermediate step between squamous and intestinal lining of the oesophagus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05170.x","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T16:01:11Z","timestamp":1338825671000},"page":"282-289","source":"Crossref","is-referenced-by-count":22,"title":["Columnar\u2010lined oesophagus without intestinal metaplasia: results from a cohort with a mean follow\u2010up of 7\u00a0years"],"prefix":"10.1111","volume":"36","author":[{"given":"A.","family":"Dias Pereira","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Instituto Portugu\u00eas de Oncologia de Lisboa de Francisco Gentil, EPE Lisbon Portugal"},{"name":"Faculdade de Ci\u00eancias da Sa\u00fade Universidade da Beira Interior Covilh\u00e3 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Chaves","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Sa\u00fade Universidade da Beira Interior Covilh\u00e3 Portugal"},{"name":"Department of Pathology Instituto Portugu\u00eas de Oncologia de Lisboa de Francisco Gentil, EPE Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"725","article-title":"Pepticulcer of the esophagus","volume":"5","author":"Tileston W","year":"1906","journal-title":"A J Med 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