{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:30:32Z","timestamp":1777710632196,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T00:00:00Z","timestamp":1341878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,9]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Patients with irritable bowel syndrome with diarrhoea (\n IBS<\/jats:styled-content>\n \u2010\n D<\/jats:styled-content>\n ) experience restriction in daily activities and decreased health\u2010related quality of life (\n QOL<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To investigate effects of alosetron on patient\u2010reported health\u2010related\n QOL<\/jats:styled-content>\n , satisfaction and productivity in women with severe\n IBS<\/jats:styled-content>\n \u2010\n D<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 705 women (severe\n IBS<\/jats:styled-content>\n \u2010\n D<\/jats:styled-content>\n , Rome\n II<\/jats:styled-content>\n criteria) randomised to alosetron 0.5\u00a0mg\n QD<\/jats:styled-content>\n , 1\u00a0mg\n QD<\/jats:styled-content>\n , 1\u00a0mg\n BID<\/jats:styled-content>\n , or placebo for 12\u00a0weeks were studied.\n IBSQOL<\/jats:styled-content>\n , treatment satisfaction, daily activities, and lost workplace productivity (\n LWP<\/jats:styled-content>\n ) were evaluated at randomisation and Week 12.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One or more doses of alosetron significantly improved all\n IBSQOL<\/jats:styled-content>\n domains except for sexual function from baseline vs. placebo. The magnitude of\n IBSQOL<\/jats:styled-content>\n changes was consistent with a clinically meaningful effect. Alosetron 0.5\u00a0mg\n QD<\/jats:styled-content>\n and 1\u00a0mg\n BID<\/jats:styled-content>\n significantly reduced\n IBS<\/jats:styled-content>\n interference with social\/leisure activities and\n LWP<\/jats:styled-content>\n from baseline vs. placebo [social\/leisure (mean\u00a0\u00b1\n S.E.<\/jats:styled-content>\n ) days lost: \u22126.7\u00a0\u00b1\u00a00.8, \u22127.0\u00a0\u00b1\u00a00.9,\n P<\/jats:italic>\n \u00a0<\u00a00.01;\n LWP<\/jats:styled-content>\n (mean\u00a0\u00b1\u00a0\n S.E.<\/jats:styled-content>\n )\u00a0h lost: \u221211.0\u00a0\u00b1\u00a03.3, \u221221.1\u00a0\u00b1\u00a04.1,\n P<\/jats:italic>\n \u00a0<\u00a00.05 respectively]. Significantly more patients treated with alosetron reported satisfaction vs. placebo. Improvements in\n IBSQOL<\/jats:styled-content>\n ,\n LWP<\/jats:styled-content>\n , and treatment satisfaction significantly correlated with global improvement of\n IBS<\/jats:styled-content>\n symptoms. The incidence of adverse events with alosetron was low with constipation being the most commonly reported event. A single case of ischaemic colitis occurred, in a patient receiving alosetron 0.5\u00a0mg\n QD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In women with severe\n IBS<\/jats:styled-content>\n \u2010\n D<\/jats:styled-content>\n , alosetron treatment, including 0.5\u00a0mg\n QD<\/jats:styled-content>\n , resulted in statistically significant and clinically relevant improvements in health\u2010related\n QOL<\/jats:styled-content>\n , restriction of daily activities and treatment satisfaction over placebo.\n IBS<\/jats:styled-content>\n symptom improvement corresponded with positive changes in\n IBSQOL<\/jats:styled-content>\n ,\n LWP<\/jats:styled-content>\n and treatment satisfaction.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05208.x","type":"journal-article","created":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T21:23:11Z","timestamp":1341955391000},"page":"437-448","source":"Crossref","is-referenced-by-count":57,"title":["Randomised clinical trial: alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea\u2010predominant\n IBS<\/scp>"],"prefix":"10.1111","volume":"36","author":[{"given":"F.","family":"Cremonini","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA"},{"name":"Prometheus Laboratories Inc. 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