{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:38:45Z","timestamp":1793813925880,"version":"4.6.1"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T00:00:00Z","timestamp":1343174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The intestinal microbiota is involved in the pathogenesis of inflammatory bowel disease (\n                      <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                      ). Faecal microbiota transplantation (\n                      <jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>\n                      ) has been used for the management of\n                      <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                      as well as infectious diarrhoea.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To undertake a systematic review of\n                      <jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>\n                      in patients with\n                      <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The systematic review followed Cochrane and\n                      <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content>\n                      recommendations. Nine electronic databases were searched in addition to hand searching and contacting experts. Inclusion criteria were reports (\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      , nonrandomised trials, case series and case reports) of\n                      <jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>\n                      in patients with\n                      <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 5320 articles identified, 17 fulfilled the inclusion criteria, none of which were controlled trials. There were nine case series\/case reports of patients receiving\n                      <jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>\n                      for management of their\n                      <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                      , and eight where\n                      <jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>\n                      was for the treatment of infectious diarrhoea in\n                      <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                      . These 17 articles reported on 41 patients with\n                      <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                      (27\n                      <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                      , 12 Crohn's, 2 unclassified) with a follow\u2010up period of between 2\u00a0weeks and 13\u00a0years. Where reported,\n                      <jats:styled-content style=\"fixed-case\">FMT<\/jats:styled-content>\n                      was administered via colonoscopy\/enema (26\/33) or via enteral tube (7\/33). In patients treated for their\n                      <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                      , the majority experienced a reduction of symptoms (19\/25), cessation of\n                      <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                      medications (13\/17) and disease remission (15\/24). There was resolution of\n                      <jats:italic>C. difficile<\/jats:italic>\n                      infection in all those treated for such (15\/15).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Whilst the available evidence is limited and weak, it suggests that faecal microbiota transplantation has the potential to be an effective and safe treatment for\n                      <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                      , at least when standard treatments have failed. Well\u2010designed randomised controlled trials are required to investigate these findings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1365-2036.2012.05220.x","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T04:51:42Z","timestamp":1343191902000},"page":"503-516","source":"Crossref","is-referenced-by-count":267,"title":["Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease"],"prefix":"10.1111","volume":"36","author":[{"given":"J. L.","family":"Anderson","sequence":"first","affiliation":[{"name":"Diabetes and Nutritional Sciences Division School of Medicine, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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