{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:39:41Z","timestamp":1782603581031,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T00:00:00Z","timestamp":1147392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    A 65\u2010year\u2010old man underwent parathyroidectomy for hyperparathyroidism secondary to renal failure. Intra\u2010operatively he received methylene blue infusion (7.5\u2003mg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , a total of 650\u2003mg in 500\u2003ml 0.9% sodium chloride) for visualisation of parathyroid glands. At the end of surgery, following extubation he developed agitation, intense shivering and hyperpyrexia, and his level of consciousness decreased to a Glasgow Coma score of 7. The differential diagnoses included methylene blue toxicity or malignant hyperpyrexia. His lungs were ventilated, and intravenous dantrolene was administered to control hyperpyrexia. Haemodialysis was started to remove the methylene blue dye. We review the literature on the pharmacological actions of methylene blue, and discuss the differential diagnosis and management of this patient.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2044.2006.04619.x","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T11:33:06Z","timestamp":1147433586000},"page":"580-583","source":"Crossref","is-referenced-by-count":36,"title":["Hyperpyrexia and prolonged postoperative disorientation following methylene blue infusion during parathyroidectomy"],"prefix":"10.1111","volume":"61","author":[{"given":"S.","family":"Mathew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Linhartova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Raghuraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,12]]},"reference":[{"key":"e_1_2_4_2_2","unstructured":"Anonymous.Drug Data Sheet.Mayne Pharma Pvt Ltd Wellington2004.http:\/\/www.medsafe.govt.nz\/Profs\/Datasheet\/m\/methyleneBlueinj.htm[accessed 22 July 2005]."},{"key":"e_1_2_4_3_2","first-page":"23","article-title":"Methylene Blue in surgery for primary hyperparathyroidism","volume":"59","author":"Robert J","year":"1998","journal-title":"Annales d'Endocrinologie."},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000134860.73875.CF"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2003.03415_23.x"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(98)00100-7"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002280000124"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2005.04185.x"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-200305000-00010"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199603000-00012"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701355"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.2344\/0003-3006(2005)52[21:PHOUOT]2.0.CO;2"},{"key":"e_1_2_4_13_2","first-page":"80","article-title":"Hungry bone syndrome: clinical experience in its diagnosis and treatment","volume":"128","author":"Araya V","year":"2000","journal-title":"Revista Medica de Chile"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2044.2006.04619.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2044.2006.04619.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T01:24:53Z","timestamp":1761701093000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2044.2006.04619.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,12]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1365-2044.2006.04619.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2044.2006.04619.x","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,12]]}}}