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Haemolysis may result. Agglutination results in impaired perfusion, resulting in symptomatic Raynaud's phenomenon and acrocyanosis. Haemolysis can result in anaemia and thrombotic events caused by microvascular occlusion, in addition to haemoglobinuria and renal failure. Peri\u2010operative hypothermia is common in all patients and may be associated with significant morbidity, but is potentially catastrophic in a patient suffering from cold agglutinin disease.<\/jats:p>","DOI":"10.1111\/j.1365-2044.2006.04650.x","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T11:33:06Z","timestamp":1147433586000},"page":"593-596","source":"Crossref","is-referenced-by-count":12,"title":["Major colorectal surgery in a patient with cold agglutinin disease"],"prefix":"10.1111","volume":"61","author":[{"given":"S.","family":"Young","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Haldane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,12]]},"reference":[{"key":"e_1_2_4_2_2","unstructured":"Pathogenesis of auto\u2010immune haemolytic anaemia. 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