{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:20:56Z","timestamp":1787808056623,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T00:00:00Z","timestamp":1157932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Peri\u2010operative beta\u2010blockade has been shown to reduce the incidence of postoperative cardio\u2010 vascular complications including cardiac death in high\u2010risk non\u2010cardiac surgical patients. However, the recent analysis by Lindenauer\n                    <jats:italic>et\u00a0al.<\/jats:italic>\n                    suggests that it is inappropriate to administer beta\u2010blockers blindly to all surgical patients. In an attempt to determine the appropriateness of peri\u2010operative beta\u2010blocker administration across patients with a spectrum of cardiovascular risks, we have examined studies of intermediate\u2010risk patient groups (that is those undergoing intermediate risk surgery or those with a Lee Revised Cardiac Risk Score of\u22642). We analysed data from randomised prospective studies of the effects of acute peri\u2010operative beta\u2010blockade on the incidence of peri\u2010operative myocardial ischaemia. By examining the demographics and surgical interventions in these patients, we have compared these studies with other studies of peri\u2010operative silent myocardial ischaemia representing patients of similar risk. We thus estimated the expected long\u2010term postoperative cardiovascular complication rate associated with myocardial ischaemia in these patients in terms of number needed to treat for ischaemia prevention and for prevention of major cardiovascular complications. Prevention of peri\u2010operative myocardial ischaemia with acute beta\u2010blockade in non\u2010cardiac surgical patients with 1\u20132 RCRI clinical risk factors can be achieved with a number needed to treat of 10. It is not associated with a significant increase in drug associated side\u2010effects. However, acute beta\u2010blockade shows no real benefit in the prevention of major cardiovascular complications in intermediate risk non\u2010vascular surgical patients with a number\u2010needed\u2010to\u2010treat of 833. Vascular surgical patients undergoing intermediate\u2010risk surgery may benefit from the protective effects of acute peri\u2010operative beta\u2010blockade, however, with a number\u2010needed\u2010to\u2010treat of 68 it would require a randomised clinical trial of over 24\u2003000 patients to prove their efficacy.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2044.2006.04788.x","type":"journal-article","created":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T13:47:05Z","timestamp":1157982425000},"page":"924-931","source":"Crossref","is-referenced-by-count":21,"title":["Acute peri\u2010operative beta blockade in intermediate\u2010risk patients"],"prefix":"10.1111","volume":"61","author":[{"given":"B. M.","family":"Biccard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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