{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:35:27Z","timestamp":1793144127474,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T00:00:00Z","timestamp":1160956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Magnesium sulphate is used extensively in the treatment of eclampsia, and is also used to treat refractory arrhythmias, asthma, myocardial ischaemia and acute respiratory failure. We studied the interaction between magnesium sulphate and the anaesthetic agents propofol, rocuronium bromide and fentanyl citrate. This randomised, double blind study was conducted in 50 patients. The magnesium group A (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200325) received 30\u2003mg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    magnesium sulphate before induction of anaesthesia and 10\u2003mg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    continuously intra\u2010operatively until the end of surgery. Group B (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200325) received the same volume of isotonic saline. Propofol, rocuronium and fentanyl infusions were started and the patients lungs' were ventilated with 33% oxygen in nitrous oxide. Anaesthetic depth was maintained at a bispectral index value of between 40 and 60. Muscle relaxation was maintained at a train\u2010of\u2010four count of 1 throughout surgery using neuromuscular monitoring. The fentanyl infusion was titrated to haemodynamic variables: heart rate and blood pressure. We concluded that magnesium sulphate has anaesthetic, analgesic and muscle relaxation effects and significantly reduces the drug requirements of propofol, rocuronium and fentanyl during anaesthesia.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2044.2006.04801.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T02:19:05Z","timestamp":1161137945000},"page":"1058-1063","source":"Crossref","is-referenced-by-count":55,"title":["The role of magnesium as an adjuvant during general anaesthesia"],"prefix":"10.1111","volume":"61","author":[{"given":"K.","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Vohra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/83.2.302"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199201000-00021"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90572-6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1152\/ajplegacy.1906.15.4.387","article-title":"Physiological and pharmacological studies on magnesium salts. The toxicity of intravenous injection, in particular the effects upon the centers of the medulla","volume":"15","author":"Meltzer SJ","year":"1906","journal-title":"American Journal of Physiology"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1916.02590160009004"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S0022-3565(25)27514-0","article-title":"Failure to anaesthetize human subjects by intravenous administration of magnesium sulphate. Journal of","volume":"154","author":"Somjen G","year":"1966","journal-title":"Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_5_8_2","first-page":"1273","article-title":"The anaesthetic contribution of magnesium sulphate and ritodrine hydrochloride in rats","volume":"20","author":"Thompson SLO","year":"1988","journal-title":"Anesthesia and Analgesia"},{"key":"e_1_2_5_9_2","first-page":"463","volume-title":"Anaesthesia","author":"Savarenese JJ","year":"2000"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1213\/00000539-199701000-00033","article-title":"Electroencephalographic bispectral index correlate with intraoperative recall and depth of propofol induced sedation","volume":"84","author":"Lui J","year":"1997","journal-title":"Anesthesia and Analgesia"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199704000-00014"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aef238"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200211000-00017"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2346.2001.00921.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1152\/ajplegacy.1906.16.2.233","article-title":"Physiological and pharmacological studies on magnesium salts. 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Narcotizing effects of magnesium salts upon nerve fibers","volume":"16","author":"Meltzer SJ","year":"1906","journal-title":"American Journal of Physiology"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.49.4.845"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1916.02590160009004"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-196807000-00027"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/79.1.122"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/74.4.405"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90225-E"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(91)90100-C"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199602000-00011"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199807000-00042"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(79)90401-0"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2044.2006.04801.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2044.2006.04801.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:14:34Z","timestamp":1761675274000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2044.2006.04801.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,16]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1365-2044.2006.04801.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2044.2006.04801.x","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,16]]}}}