{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:26:25Z","timestamp":1774578385728,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T00:00:00Z","timestamp":1162857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The aim of the study was to compare oral midazolam and inhaled nitrous oxide as sedative agents during the management of children aged 5\u201310\u2003years presenting for extraction of primary teeth under local anaesthetic. Subjects required two visits for the extraction of four primary teeth, one in each quadrant of the mouth, and were randomly allocated to be given nitrous oxide 30% in oxygen or oral midazolam 0.3\u2003mg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    at the first visit, the other technique being used at the second visit. Vital signs, sedation levels and behavioural scores were recorded, and postoperative recall and satisfaction were reported by the patients. Thirty\u2010five children, with a mean [range] age of 7.4\u2003[5\u201310] years, completed the treatment. The mean dose of oral midazolam given was 8.6\u2003[3.3\u201316.5] mg. The mean times taken to achieve the maximum level of sedation for midazolam and nitrous oxide sedation were 15.9\u2003[2\u201330] min and 6.8\u2003[2\u201310] min, respectively. Physiological parameters remained within acceptable clinical limits for both types of sedation. Oral midazolam was considered acceptable by 59% and was preferred by 36%. Oral midazolam sedation in 5 to 10\u2010year\u2010old children was shown to be as safe and effective as nitrous oxide in oxygen sedation for extraction of primary teeth but would not be the method of choice for all patients.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2044.2006.04835.x","type":"journal-article","created":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T05:04:18Z","timestamp":1162875858000},"page":"1138-1144","source":"Crossref","is-referenced-by-count":42,"title":["A comparison of oral midazolam and nitrous oxide sedation for dental extractions in children"],"prefix":"10.1111","volume":"61","author":[{"given":"K. E.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. M.","family":"Girdler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. R.","family":"Welbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.1996.tb00201.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4809708"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4800471a"},{"key":"e_1_2_5_5_2","first-page":"1","volume-title":"A Conscious Decision","author":"Donaldson L","year":"2000"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199809210-00069"},{"key":"e_1_2_5_7_2","first-page":"37","article-title":"A comparison of three doses of commercially prepared oral midazolam syrup in children","volume":"94","author":"Cote CJ","year":"2002","journal-title":"Anesthesia and Analgesia"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03008315"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.2000.tb05983.x"},{"key":"e_1_2_5_10_2","first-page":"97","article-title":"Conscious sedation by oral administration of midazolam in paediatric dental patients","volume":"25","author":"Erlandsson AL","year":"2001","journal-title":"Swedish Dental Journal"},{"key":"e_1_2_5_11_2","first-page":"235","article-title":"The effect of orally administered midazolam on children of three age groups during restorative dental care","volume":"21","author":"Fraone G","year":"1999","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_5_12_2","first-page":"175","article-title":"An evaluation of oral and nasal midazolam for pediatric dental sedation","volume":"61","author":"Hartgraves PM","year":"1994","journal-title":"Journal of Dentistry for Children"},{"key":"e_1_2_5_13_2","first-page":"350","article-title":"Evaluation of two dosages of oral midazolam as a conscious sedation agent for physically and neurologically compromised pediatric dental patients","volume":"16","author":"Silver T","year":"1994","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2002.02784.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg278"},{"key":"e_1_2_5_16_2","first-page":"236","article-title":"Effects of nitrous oxide on diazepam sedation of young children","volume":"18","author":"Houpt MI","year":"1996","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_5_17_2","first-page":"364","article-title":"Assessing chloral hydrate dosage for young children","volume":"52","author":"Houpt MI","year":"1985","journal-title":"Journal of Dentistry for Children"},{"key":"e_1_2_5_18_2","volume-title":"Conscious Sedation in the Provision of Dental Care.","author":"Department of Health.","year":"2003"},{"key":"e_1_2_5_19_2","first-page":"30","article-title":"Die Effekte fruherer Operationen auf Narkose und Operationsangste bei Kindern","volume":"35","author":"Breitkopf L","year":"1986","journal-title":"Der Anaesthesist"},{"key":"e_1_2_5_20_2","first-page":"221","article-title":"Oral midazolam syrup: a safer alternative for pediatric sedation","volume":"20","author":"Dionne R","year":"1999","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200302000-00017"},{"key":"e_1_2_5_22_2","first-page":"126","article-title":"Nasal versus oral midazolam sedation for pediatric dental patients","volume":"71","author":"Lee\u2010Kim SJ","year":"2004","journal-title":"Journal of Dentistry for Children"},{"key":"e_1_2_5_23_2","first-page":"295","article-title":"Experience with midazolam sedative in the dental treatment of unco\u2010operative children","volume":"60","author":"Krafft TC","year":"1993","journal-title":"Journal of Dentistry for Children"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2044.2006.04835.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2044.2006.04835.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:02:12Z","timestamp":1761674532000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2044.2006.04835.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,7]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1365-2044.2006.04835.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2044.2006.04835.x","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,7]]}}}