{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:50:01Z","timestamp":1776451801748,"version":"3.51.2"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T00:00:00Z","timestamp":1275436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We performed a prospective randomised trial to evaluate the analgesic efficacy of interpleural analgesia in patients undergoing hepatic resection. The control group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200325) received multimodal analgesia with intravenous morphine patient\u2010controlled analgesia; in addition, the interventional group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200325) received interpleural analgesia with a 20\u2010ml loading dose of levo bupivacaine 0.5% followed by a continuous infusion of levobupivacaine 0.125%. Outcome measures included pain intensity on movement using a visual analogue scale over 24 h, cumulative morphine and rescue analgesia requirements, patient satisfaction, hospital stay and all adverse events. Patients in the interpleural group were less sedated and none required treatment for respiratory depression compared to 6 (24%) in the control group (p&lt; 0.01). Patients in the interpleural group also had lower pain scores during movement in the first 24 h. Patients\u2019 satisfaction, opioid requirements and duration of hospital stay were similar. We conclude that continuous interpleural analgesia augments intravenous morphine analgesia, decreases postoperative sedation and reduces respiratory depression after hepatic resection.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2044.2010.06384.x","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T12:15:59Z","timestamp":1275480959000},"page":"721-728","source":"Crossref","is-referenced-by-count":12,"title":["Interpleural analgesia for attenuation of postoperative pain after hepatic 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