{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T12:24:19Z","timestamp":1783772659404,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T00:00:00Z","timestamp":1314576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The postoperative respiratory and analgesic effects of dexmedetomidine and morphine have not been compared in children with sleep apnoea having adenotonsillectomy. In a randomised double\u2010blind study we recruited 60 children, aged 2\u201313\u2003years, who received either intravenous dexmedetomidine 1\u2003\u03bcg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    or morphine 100\u2003\u03bcg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    on anaesthetic induction. End\u2010tidal carbon dioxide, Children\u2019s Hospital of Eastern Ontario Pain Scale score and supplementary morphine administration were recorded every 15\u2003min for 60\u2003min postoperatively. Over 60\u2003min, mean (SD) end\u2010tidal carbon dioxide was consistently lower with dexmedetomidine compared with morphine (5.4 (0.7)\u2003kPa vs 6.0 (0.6)\u2003kPa, respectively; p\u2003=\u20030.001). Mean (SD) pain scores were higher with dexmedetomidine (8.1 (2.0) immediately postoperatively and 6.7 (1.0) at 60\u2003min vs 7.6 (1.8) and 6.3 (0.7), respectively, with morphine (p\u2003=\u20030.023)). More patients required supplementary morphine with dexmedetomidine (13\/30 (43%) vs 21\/30 (70%); p\u2003=\u20030.037). Postoperatively, dexmedetomidine produced less respiratory depression than morphine, but less effective analgesia.\n                  <\/jats:p>\n                  <jats:p>\n                    You can respond to this article at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.anaesthesiacorrespondence.com\">http:\/\/www.anaesthesiacorrespondence.com<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2044.2011.06817.x","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:40:51Z","timestamp":1314837651000},"page":"989-993","source":"Crossref","is-referenced-by-count":34,"title":["Postoperative respiratory and analgesic effects of dexmedetomidine or morphine for adenotonsillectomy in children with obstructive sleep apnoea"],"prefix":"10.1111","volume":"66","author":[{"given":"P. J.","family":"Zhuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. F.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. J.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/00034894921010S112","article-title":"Current indications for tonsillectomy and adenoidectomy","volume":"155","author":"Bluestone CD","year":"1992","journal-title":"Annals of Otology, Rhinology and Laryngology"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004311-198802610-00012"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200202000-00015"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1996.tb01310.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200404000-00009"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000257100.31779.41"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001503-200008000-00007"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc712"},{"key":"e_1_2_6_10_2","first-page":"395","article-title":"CHEOPS: a behavioral scale for rating postoperative pain in children","volume":"9","author":"McGrath PJ","year":"1985","journal-title":"Advances in Pain Research and Therapy"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03011261"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.93.5.784"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181e33429"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181ee82fa"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200059020-00012"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200004000-00011"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200008000-00016"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1213\/00000539-199711000-00033","article-title":"Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine","volume":"85","author":"Talke P","year":"1997","journal-title":"Anesthesia and Analgesia"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2044.2011.06817.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2044.2011.06817.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:35:44Z","timestamp":1761669344000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2044.2011.06817.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,29]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1365-2044.2011.06817.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2044.2011.06817.x","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,29]]}}}