{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:53:05Z","timestamp":1791255185057,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T00:00:00Z","timestamp":1328745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The availability of sugammadex as a selective encapsulating agent for rocuronium has led to speculation that it may be useful in mitigating rocuronium\u2010induced anaphylaxis. Off\u2010label use of sugammadex for this indication has already been documented in case reports although there are theoretical objections to the likelihood of an allergen\u2010binding agent's being able to attenuate the immunological cascade of anaphylaxis. Using a cutaneous model of anaphylaxis in rocuronium\u2010sensitised patients, we were unable to demonstrate that sugammadex was effective in attenuating the type\u20101 hypersensitivity reaction after it has been triggered by rocuronium, but we were able to demonstrate that these patients are anergic to sugammadex\u2010bound rocuronium. These findings demonstrate that a cyclodextrin can bind an allergen and exclude it from interacting with the immune system, and may potentially lead to novel applications in other allergic diseases. However, there is no evidence that sugammadex should be used for the treatment of rocuronium\u2010induced anaphylaxis, and clinical management should follow established protocols.<\/jats:p>","DOI":"10.1111\/j.1365-2044.2011.06995.x","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T14:42:16Z","timestamp":1328798536000},"page":"266-273","source":"Crossref","is-referenced-by-count":61,"title":["The role of sugammadex in the development and modification of an allergic response to rocuronium: evidence from a cutaneous model*"],"prefix":"10.1111","volume":"67","author":[{"given":"R. C.","family":"Clarke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. H. M.","family":"Sadleir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. R.","family":"Platt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000082993.84883.7D"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161208786369704"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2008.02.001"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/353855a0"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000244594.63318.fc"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000265152.78943.74"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318190bc32"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200209000-00018"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008694726564"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2009.06177_1.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq366"},{"key":"e_1_2_7_13_2","unstructured":"PedersenNA FindsenL OlsenKS.Should sugammadex be used for the treatment of anaphylaxis induced by rocuronium?Proceedings of the 2010 Annual Meeting of the American Society of Anesthesiologists 2010.http:\/\/www.tinyurl.com\/7vgmj89(accessed 28\/11\/2011)."},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer211"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2009.06177_2.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3281f8290c"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2007.03.013"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)83033-6"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3283036a90"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00563.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90266-I"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2004.03757.x"},{"key":"e_1_2_7_23_2","first-page":"55","article-title":"Cross\u2010reactivity of rocuronium with other neuromuscular blocking agents","volume":"11","author":"Laxenaire MC","year":"1995","journal-title":"European Journal of Anaesthesiology"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2008.05733.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2011.06729.x"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2044.2011.06995.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2044.2011.06995.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:11:39Z","timestamp":1761671499000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2044.2011.06995.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,9]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1365-2044.2011.06995.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2044.2011.06995.x","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,9]]}}}