{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T05:23:14Z","timestamp":1794547394885,"version":"4.9.1"},"reference-count":4,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2012,5]]},"abstract":"Summary<\/jats:title>\n \n The purpose of this study was to use some statistical methods to assess if randomised controlled trials (RCTs) published by one particular author (Fujii) contained data of unusual consistency. I searched seven electronic databases, retrieving 168 RCTs published by this author between 1991 and July 2011. I extracted rates for categorical variables and means (SDs) for continuous variables, and compared these published distributions with distributions that would be expected by chance. The published distributions of 28\/33 variables (85%) were inconsistent with the expected distributions, such that the likelihood of their occurring ranged from 1 in 25 to less than 1 in 1\u2003000\u2003000\u2003000\u2003000\u2003000\u2003000\u2003000\u2003000\u2003000\u2003000\u2003000 (1 in 10\n 33<\/jats:sup>\n ), equivalent to p values of 0.04 to <\u20031\u2003\u00d7\u200310\n \u221233<\/jats:sup>\n , respectively. In 141 human studies, 13\/13 published continuous variable distributions were inconsistent with expected, their likelihoods being: weight <\u20031 in 10\n 33<\/jats:sup>\n ; age <\u20031 in 10\n 33<\/jats:sup>\n ; height <\u20031 in 10\n 33<\/jats:sup>\n ; last menstrual period 1 in 4.5\u2003\u00d7\u200310\n 15<\/jats:sup>\n ; baseline blood pressure 1 in 4.2\u2003\u00d7\u200310\n 5<\/jats:sup>\n ; gestational age 1 in 28; operation time <\u20031 in 10\n 33<\/jats:sup>\n ; anaesthetic time <\u20031 in 10\n 33<\/jats:sup>\n ; fentanyl dose 1 in 6.3\u2003\u00d7\u200310\n 8<\/jats:sup>\n ; operative blood loss 1 in 5.6\u2003\u00d7\u200310\n 9<\/jats:sup>\n ; propofol dose 1 in 7.7\u2003\u00d7\u200310\n 7<\/jats:sup>\n ; paracetamol dose 1 in 4.4\u2003\u00d7\u200310\n 2<\/jats:sup>\n ; uterus extrusion time 1 in 33. The published distributions of 7\/11 categorical variables in these 141 studies were inconsistent with the expected, their likelihoods being: previous postoperative nausea and vomiting 1 in 2.5\u2003\u00d7\u200310\n 6<\/jats:sup>\n ; motion sickness 1 in 1.0\u2003\u00d7\u200310\n 4<\/jats:sup>\n ; male or female 1 in 140; antihypertensive drug 1 in 25; postoperative headache 1 in 7.1\u2003\u00d7\u200310\n 10<\/jats:sup>\n ; postoperative dizziness 1 in 1.6\u2003\u00d7\u200310\n 6<\/jats:sup>\n ; postoperative drowsiness 1 in 3.8\u2003\u00d7\u200310\n 4<\/jats:sup>\n . Distributions for individual RCTs were inconsistent with the expected in 96\/134 human studies by Fujii et\u00a0al. that reported more than two continuous variables, their likelihood ranging from 1 in 22 to 1 in 140\u2003000\u2003000\u2003000 (1 in 1.4\u2003\u00d7\u200310\n 11<\/jats:sup>\n ), compared with 12\/139 RCTs by other authors. In 26 canine studies, the distributions of 8\/9 continuous variables were inconsistent with the expected, their likelihoods being: right atrial pressure <\u20031 in 10\n 33<\/jats:sup>\n ; diaphragmatic stimulation (100\u2003Hz) <\u20031 in 10\n 33<\/jats:sup>\n ; pulmonary artery occlusion pressure <\u20031 in 10\n 33<\/jats:sup>\n ; diaphragmatic stimulation (20\u2003Hz) <\u20031 in 10\n 33<\/jats:sup>\n ; heart rate 1 in 6.3\u2003\u00d7\u200310\n 10<\/jats:sup>\n ; mean pulmonary artery pressure 1 in 2.2\u2003\u00d7\u200310\n 14<\/jats:sup>\n ; mean arterial pressure 1 in 6.3\u2003\u00d7\u200310\n 7<\/jats:sup>\n ; cardiac output 1 in 110. Distributions were inconsistent with the expected in 21\/24 individual canine studies that reported more than two continuous variables, their likelihood ranging from 1 in 345 to 1 in 51\u2003000\u2003000\u2003000\u2003000 (1 in 5.1\u2003\u00d7\u200310\n 13<\/jats:sup>\n ).\n <\/jats:p>","DOI":"10.1111\/j.1365-2044.2012.07128.x","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T14:00:24Z","timestamp":1331215224000},"page":"521-537","source":"Crossref","is-referenced-by-count":230,"title":["The analysis of 168 randomised controlled trials to test data integrity"],"prefix":"10.1111","volume":"67","author":[{"given":"J. B.","family":"Carlisle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,8]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200004000-00053"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2010.06295.x"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004125.pub2"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2010.06557.x"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2044.2012.07128.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2044.2012.07128.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1365-2044.2012.07128.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2044.2012.07128.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:55:12Z","timestamp":1761677712000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2044.2012.07128.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,8]]},"references-count":4,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1365-2044.2012.07128.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2044.2012.07128.x","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,8]]}}}