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This encapsulation should also improve the safety profile of the local anaesthetic as it is released at a slower rate. Work with naturally occurring local anaestheticss has also shown promise in the area of reducing systemic and neurotoxicity. Extended duration local anaesthetic formulations in current development or clinical use include liposomes, hydrophobic based polymer particles such as Poly(lactic\u2010co\u2010glycolic acid) microspheres, pasty injectable and solid polymers like Poly(sebacic\u2010co\u2010ricinoleic acid) P(SA:RA) and their combination with synthetic and natural local anaesthetic. Their duration of action, rationale and limitations are reviewed. Direct comparison of the different agents is limited by their chemical properties, the drug doses encapsulated and the details of in vivo models described.<\/jats:p>","DOI":"10.1111\/j.1365-2044.2012.07168.x","type":"journal-article","created":{"date-parts":[[2012,5,18]],"date-time":"2012-05-18T09:26:03Z","timestamp":1337333163000},"page":"906-916","source":"Crossref","is-referenced-by-count":35,"title":["Extended release formulations for local anaesthetic agents"],"prefix":"10.1111","volume":"67","author":[{"given":"C. F.","family":"Weiniger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Golovanevski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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