{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:46:21Z","timestamp":1792683981749,"version":"4.5.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T00:00:00Z","timestamp":1137715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Albino phenotypes are documented in a variety of species including the domestic cat. As albino phenotypes in other species are associated with <jats:italic>tyrosinase<\/jats:italic> (<jats:italic>TYR)<\/jats:italic> mutations, <jats:italic>TYR<\/jats:italic> was proposed as a candidate gene for albinism in cats. An Oriental and Colourpoint Shorthair cat pedigree segregating for albinism was analysed for association with <jats:italic>TYR<\/jats:italic> by linkage and sequence analyses. Microsatellite <jats:italic>FCA931<\/jats:italic>, which is closely linked to <jats:italic>TYR<\/jats:italic> and <jats:italic>TYR<\/jats:italic> sequence variants were tested for segregation with the albinism phenotype. Sequence analysis of genomic DNA from wild\u2010type and albino cats identified a cytosine deletion in <jats:italic>TYR<\/jats:italic> at position 975 in exon 2, which causes a frame shift resulting in a premature stop codon nine residues downstream from the mutation. The deletion mutation in <jats:italic>TYR<\/jats:italic> and an allele of <jats:italic>FCA931<\/jats:italic> segregated concordantly with the albino phenotype. Taken together, our results suggest that the <jats:italic>TYR<\/jats:italic> gene corresponds to the <jats:italic>colour<\/jats:italic> locus in cats and its alleles, from dominant to recessive, are as follows: <jats:italic>C<\/jats:italic> (<jats:italic>full colour<\/jats:italic>)\u2003&gt;\u2003<jats:italic>c<\/jats:italic><jats:sup><jats:italic>b<\/jats:italic><\/jats:sup> (<jats:italic>burmese<\/jats:italic>)\u2003\u2003<jats:italic>c<\/jats:italic><jats:sup><jats:italic>s<\/jats:italic><\/jats:sup> (<jats:italic>siamese<\/jats:italic>)\u2003&gt;\u2003<jats:italic>c<\/jats:italic> (<jats:italic>albino<\/jats:italic>).<\/jats:p>","DOI":"10.1111\/j.1365-2052.2005.01409.x","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T10:47:54Z","timestamp":1137754074000},"page":"175-178","source":"Crossref","is-referenced-by-count":92,"title":["Albinism in the domestic cat (<i>Felis catus<\/i>) is associated with a <i>tyrosinase<\/i> (<i>TYR<\/i>) mutation"],"prefix":"10.1111","volume":"37","author":[{"given":"D. L.","family":"Imes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"Geary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Grahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,20]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/127558c0"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-004-4002-8"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2004.01213.x"},{"key":"e_1_2_3_5_1","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1523\/JNEUROSCI.02-08-01024.1982","article-title":"Morphology and distribution of retinal ganglion cells projecting to different layers of the dorsal lateral geniculate nucleus in normal and Siamese cats","volume":"2","author":"Leventhal A.G.","year":"1982","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3929383"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2005.01253.x"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075762"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.5743"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022006606796"},{"key":"e_1_2_3_11_1","first-page":"113","volume-title":"Genetics for Cat Breeders","author":"Robinson R.","year":"1991"},{"key":"e_1_2_3_12_1","first-page":"6.11","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook J.","year":"2001"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-002-2249-5"},{"key":"e_1_2_3_14_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/oxfordjournals.jhered.a107069","article-title":"A pink eyed dilution in the cat","volume":"52","author":"Todd N.B.","year":"1951","journal-title":"Journal of Heredity"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00126932"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2052.2005.01409.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2052.2005.01409.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T05:43:30Z","timestamp":1695966210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2052.2005.01409.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,20]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1365-2052.2005.01409.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2052.2005.01409.x","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"value":"0268-9146","type":"print"},{"value":"1365-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,20]]}}}