{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T21:56:39Z","timestamp":1762898199289},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T00:00:00Z","timestamp":1147737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We report the chromosomal assignment of 18 porcine genes to human homologues using the INRA\u2010Minnesota swine radiation hybrid panel (IMpRH). These genes (<jats:italic>CACNA1C<\/jats:italic>, <jats:italic>COL2A1<\/jats:italic>, <jats:italic>CPNE8<\/jats:italic>, <jats:italic>C3F<\/jats:italic>, <jats:italic>C12ORF4<\/jats:italic>, <jats:italic>DDX11<\/jats:italic>, <jats:italic>GDF11<\/jats:italic>, <jats:italic>HOXC8<\/jats:italic>, <jats:italic>KCNA1<\/jats:italic>, <jats:italic>MDS028<\/jats:italic>, <jats:italic>TMEM106C<\/jats:italic>, <jats:italic>NR4A1<\/jats:italic>, <jats:italic>PHB2<\/jats:italic>, <jats:italic>PRICKLE1<\/jats:italic>, <jats:italic>Q6ZUQ4<\/jats:italic>, <jats:italic>SCN8A<\/jats:italic>, <jats:italic>TUBA8<\/jats:italic> and <jats:italic>USP18<\/jats:italic>) are located on porcine chromosome 5 (SSC5) and represent positional and functional candidates for arthrogryposis multiplex congenita (AMC), which maps to SSC5. <jats:italic>CPNE8, PRICKLE1, Q6ZUQ4<\/jats:italic> and <jats:italic>TUBA8<\/jats:italic> were mapped to the interval for pig <jats:italic>AMC<\/jats:italic> between microsatellites <jats:italic>SW152<\/jats:italic> and <jats:italic>SW904<\/jats:italic>. Three SNPs in <jats:italic>TUBA8<\/jats:italic> co\u2010segregated with the <jats:italic>AMC<\/jats:italic> phenotype in 230 pigs of our research population without recombination and could be used as a genetic marker test for <jats:italic>AMC<\/jats:italic>. In addition, we provide evidence that a small chromosomal region of HSA22q11.2 evolutionarily corresponds to SSC5q12\u2013q22 (and contains the human homologues of porcine <jats:italic>SW152<\/jats:italic>, <jats:italic>Q6ZUQ4<\/jats:italic>, <jats:italic>TUBA8<\/jats:italic> and <jats:italic>USP18<\/jats:italic>), while the regions flanking HSA22q11.2 on SSC5 correspond to HSA12p13 and HSA12q12. We identified seven distinct chromosomal blocks, further supporting extensive rearrangements between genes on HSA12 and HSA22 in the <jats:italic>AMC<\/jats:italic> region on SSC5.<\/jats:p>","DOI":"10.1111\/j.1365-2052.2006.01447.x","type":"journal-article","created":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T08:54:58Z","timestamp":1147769698000},"page":"239-244","source":"Crossref","is-referenced-by-count":13,"title":["Radiation hybrid mapping of 18 positional and physiological candidate genes for arthrogryposis multiplex congenita on porcine chromosome 5"],"prefix":"10.1111","volume":"37","author":[{"given":"S.","family":"Genini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Malek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Talbot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Nonneman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Stranzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"V\u00f6geli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-002-2242-z"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075739"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2005.01302.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-004-2403-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000048782"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-002-2236-x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2005.04.010"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/16.6.558"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5550"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075733"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6.5.371"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-002-2263-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000015095"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2052.2006.01447.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2052.2006.01447.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T02:05:48Z","timestamp":1697421948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2052.2006.01447.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,16]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1365-2052.2006.01447.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2052.2006.01447.x","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"value":"0268-9146","type":"print"},{"value":"1365-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,16]]}}}