{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:01:33Z","timestamp":1761742893728},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T00:00:00Z","timestamp":1163376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study tested positional candidate genes <jats:italic>adiponectin<\/jats:italic> (<jats:italic>ADIPOQ<\/jats:italic>) and <jats:italic>somatostatin<\/jats:italic> (<jats:italic>SST<\/jats:italic>) for effects on carcass traits in a commercially relevant cattle population. Both genes are located within a region of BTA1 previously reported to harbour quantitative trait loci (QTL) that affect marbling, quality grade, yield grade, ribeye area and weaning weight in <jats:italic>Bos taurus<\/jats:italic>\u2003\u00d7\u2003<jats:italic>Bos indicus<\/jats:italic> crosses. Except for the first intron of <jats:italic>ADIPOQ<\/jats:italic>, both genes, including over 2\u2003kb upstream of the promoters, were sequenced in five registered Angus sires to identify polymorphisms. A variable copy duplication and three single nucleotide polymorphisms (SNPs) in <jats:italic>ADIPOQ<\/jats:italic> and one SNP in <jats:italic>SST<\/jats:italic> were genotyped and tested for association with 19 traits in a 14\u2010generation pedigree of 1697 registered Angus artificial insemination sires representing all the major USA lineages of the breed. Linear models that parameterized predicted genetic merits in terms of allele substitution effects were fit by weighted least squares, and goodness\u2010of\u2010fit tests were employed to differentiate causal mutations or polymorphisms in strong linkage disequilibrium (LD) with causal mutations from markers in weak LD with QTL. We confirmed the presence of QTL affecting marbling, ribeye muscle area and fat thickness in the vicinity of <jats:italic>SST<\/jats:italic> and <jats:italic>ADIPOQ<\/jats:italic> on BTA1 in Angus; excluded <jats:italic>SST<\/jats:italic> as underlying the ribeye muscle area QTL; and excluded <jats:italic>ADIPOQ<\/jats:italic> as underlying the marbling score QTL. However, association analysis provides very limited information about QTL location and has little intrinsic value when performed in the absence of linkage or LD analysis using flanking marker data to localize the QTL effect relative to positional candidate genes.<\/jats:p>","DOI":"10.1111\/j.1365-2052.2006.01528.x","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T09:16:49Z","timestamp":1163409409000},"page":"554-562","source":"Crossref","is-referenced-by-count":47,"title":["Association analysis of <i>adiponectin<\/i> and <i>somatostatin<\/i> polymorphisms on BTA1 with growth and carcass traits in Angus cattle"],"prefix":"10.1111","volume":"37","author":[{"given":"N. S.","family":"Morsci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. D.","family":"Schnabel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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