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This design provided an opportunity to map potentially unique genetic variation associated with a parasite\u2010tolerant breed like Red Maasai, a breed developed to survive East African grazing conditions. Parasite indicator phenotypes (blood packed cell volume \u2013 PCV and faecal egg count \u2013 FEC) were collected on a weekly basis from 1064 lambs during a single 3\u2010month post\u2010weaning grazing challenge on infected pastures. The averages of last measurements for FEC (AVFEC) and PCV (AVPCV), along with decline in PCV from challenge start to end (PCVD), were used to select lambs (<jats:italic>N<\/jats:italic>\u2003=\u2003371) for genotyping that represented the tails (10% threshold) of the phenotypic distributions. Marker genotypes for 172 microsatellite loci covering 25 of 26 autosomes (1560.7\u2003c<jats:sc>m<\/jats:sc>) were scored and corrected by G<jats:sc>enoprob<\/jats:sc> prior to <jats:sc>qxpak<\/jats:sc> analysis that included Box\u2013Cox transformed AVFEC and arcsine transformed PCV statistics. Significant QTL for AVFEC and AVPCV were detected on four chromosomes, and this included a novel AVFEC QTL on chromosome 6 that would have remained undetected without Box\u2013Cox transformation methods. The most significant <jats:italic>P<\/jats:italic>\u2010values for AVFEC, AVPCV and PCVD overlapped the same marker interval on chromosome 22, suggesting the potential for a single causative mutation, which remains unknown. In all cases, the favourable QTL allele was always contributed from Red Maasai, providing support for the idea that future marker\u2010assisted selection for genetic improvement of production in East Africa will rely on markers in linkage disequilibrium with these QTL.<\/jats:p>","DOI":"10.1111\/j.1365-2052.2011.02202.x","type":"journal-article","created":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T07:27:16Z","timestamp":1304062036000},"page":"63-71","source":"Crossref","is-referenced-by-count":51,"title":["Identification of quantitative trait loci affecting resistance to gastrointestinal parasites in a double backcross population of Red Maasai and Dorper sheep"],"prefix":"10.1111","volume":"43","author":[{"given":"M. V. B.","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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