{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T22:12:22Z","timestamp":1789855942318,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T00:00:00Z","timestamp":1311292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>African animal trypanosomosis is a parasitic blood disease transmitted by tsetse flies and is widespread in sub\u2010Saharan Africa. West African taurine breeds have the ability, known as trypanotolerance, to limit parasitaemia and anaemia and remain productive in enzootic areas. Several quantitative trait loci (QTL) underlying traits related to trypanotolerance have been identified in an experimentally infected F<jats:sub>2<\/jats:sub> population resulting from a cross between taurine and zebu cattle. Although this information is highly valuable, the QTL remain to be confirmed in populations subjected to natural conditions of infection, and the corresponding regions need to be refined. In our study, 360 West African cattle were phenotyped for the packed cell volume control under natural conditions of infection in south\u2010western Burkina Faso. Phenotypes were assessed by analysing data from previous cattle monitored over 2\u2003years in an area enzootic for trypanosomosis. We further genotyped for 64 microsatellite markers mapping within four previously reported QTL on BTA02, BTA04, BTA07 and BTA13. These data enabled us to estimate the heritability of the phenotype using the kinship matrix between individuals computed from genotyping data. Thus, depending on the estimators considered and the method used, the heritability of anaemia control ranged from 0.09 to 0.22. Finally, an analysis of association identified an allele of the <jats:italic>MNB42<\/jats:italic> marker on BTA04 as being strongly associated with anaemia control, and a candidate gene, <jats:italic>INHBA<\/jats:italic>, as being close to that marker.<\/jats:p>","DOI":"10.1111\/j.1365-2052.2011.02227.x","type":"journal-article","created":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T15:03:12Z","timestamp":1311346992000},"page":"123-132","source":"Crossref","is-referenced-by-count":21,"title":["Association studies in QTL regions linked to bovine trypanotolerance in a West African crossbred population"],"prefix":"10.1111","volume":"43","author":[{"given":"G. 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