{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:24:58Z","timestamp":1770063898033,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T00:00:00Z","timestamp":1090886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess how well heart failure patients tolerate spironolactone in routine clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective analysis of 226 patients attending a specialist heart failure clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and thirty of 226 (57.5%) patients tried spironolactone at least once. Forty\u2010four of 130 (33.8%) discontinued spironolactone due to side\u2010effects after a mean of 11.1\u2003months; 59\/141 (41.8%) trials of spironolactone resulted in at least one side\u2010effect; therapy was stopped in 30\/141 (21.3%) trials due to raised potassium or creatinine. Significant risk factors for raised potassium\/creatinine were age and baseline potassium level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Potentially serious side\u2010effects are common despite appropriate use of spironolactone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2125.2004.02187.x","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T16:42:52Z","timestamp":1099413772000},"page":"554-557","source":"Crossref","is-referenced-by-count":26,"title":["Tolerability of spironolactone in patients with chronic heart failure \u2013 a cautionary message"],"prefix":"10.1111","volume":"58","author":[{"given":"Miles D.","family":"Witham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil D.","family":"Gillespie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan D","family":"Struthers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411001"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-9842(01)00200-8"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.72.852.577"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7407.147"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2003.00491.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7424.1141"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.85.4.e8"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02694-3"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00642-8"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2125.2004.02187.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2125.2004.02187.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:35:42Z","timestamp":1697427342000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2125.2004.02187.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,27]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1111\/j.1365-2125.2004.02187.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2125.2004.02187.x","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,27]]}}}