{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:42:56Z","timestamp":1762504976570},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T00:00:00Z","timestamp":1094169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>This study was undertaken to evaluate removal of 22\u2010oxacalcitriol (OCT), an active and intravenously used vitamin D3 analogue with less calcaemic activity, by polysulphone haemodialyser <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. We further compared the pharmacodynamic efficacy [suppression of intact parathyroid hormone (iPTH)] when given intravenously either during or at the end of the haemodialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>(i) Drug clearance by the polysulphone dialyser was measured during a single continuous infusion (5\u2003\u00b5g) for 30\u2003min into the arterial side of the dialyser in end\u2010stage renal failure patients with secondary hyperparathyroidism (<jats:italic>n<\/jats:italic>\u2003=\u20037). (ii) The drug adsorption by the hollowfibre membrane during incubation for 30\u2003min was measured <jats:italic>in vitro<\/jats:italic>. (iii) To evaluate efficacy, the drug was given (i.v. bolus) during or at the end of haemodialysis for 4\u2003weeks in a cross\u2010over fashion with a washout period of 8\u2003weeks (<jats:italic>n<\/jats:italic>\u2003=\u20039). Serum Ca<jats:sup>2+<\/jats:sup>, phosphate (P) and iPTH concentrations just before the initiation of the dialysis were monitored every week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(i) OCT was significantly cleared by the polysulphone haemodialyser, but the clearance declined in a time\u2010dependent manner to approach zero at 30\u2003min. Arterial (at the place between the drug infusion site and the haemodialyser column) drug concentrations did not change during the infusion (mean =\u200a2064\u2003\u00b1\u2003233\u2003pg\u2003ml<jats:sup>\u22121<\/jats:sup>). Venous (just after the dialyser) drug concentrations at 10\u2003min after the infusion were significantly lower than those of the arterial side (mean =\u200a784\u2003\u00b1\u200384\u2003pg\u2003ml<jats:sup>\u22121<\/jats:sup>); however, they increased with time and reached those of the arterial side at 30\u2003min. (ii) <jats:italic>In vitro<\/jats:italic>, OCT was adsorbed by the membrane. The amount of adsorption was concentration\u2010dependent and was lower in the presence of human serum (55\u2003\u00b1\u20034% without and 23\u2003\u00b1\u20034% with serum at 600\u2003pg\u2003ml<jats:sup>\u22121<\/jats:sup> of OCT). (iii) Although serum Ca<jats:sup>2+<\/jats:sup> and P increased and iPTH decreased by both treatment regimens (i.e. OCT administered either during or at the end of haemodialysis), these changes did not significantly differ. Mean differences (and 95% confidence interval) of Ca<jats:sup>2+<\/jats:sup>, P, and iPTH at the end of the trial were 0.03 (\u22120.04, 0.09)\u2003m<jats:sc>m<\/jats:sc>, 0.41 (\u22120.43, 1.26)\u2003mg\u2003dl<jats:sup>\u22121<\/jats:sup> and 38 (\u221242, 88)\u2003pg\u2003ml<jats:sup>\u22121<\/jats:sup>, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OCT is adsorbed by polysulphone dialyser <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. However, the pharmacodynamic effectiveness was largely independent of the administration regimen of OCT given either during or at the end of haemodialysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2125.2004.02204.x","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T16:42:52Z","timestamp":1099413772000},"page":"488-495","source":"Crossref","is-referenced-by-count":3,"title":["Adsorption of oxacalcitriol by polysulphone haemodialyser in patients with secondary hyperparathyroidism"],"prefix":"10.1111","volume":"58","author":[{"given":"Shuichi","family":"Tsuruoka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Ando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,3]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"2187","volume-title":"Brenner and Rector's the Kidney","author":"Llasch F","year":"1996"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111639"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114229"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650070713"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.suppl_10.41"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70198-3"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050349"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050348"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002280000191"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.116061"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(97)00553-7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/000456329002700114"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/cp.1999.v66.103169001"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1994.tb03309.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/oxfordjournals.jbchem.a124346","article-title":"The binding properties, with blood proteins, and tissue distribution of 22\u2010oxa\u20101 alpha,25\u2010dihydroxyvitamin D3, a noncalcemic analogue of 1 alpha, 25\u2010dihydroxyvitamin D3, in rats","volume":"115","author":"Kobayashi T","year":"1994","journal-title":"J Biochem (Tokyo)"},{"key":"e_1_2_6_17_2","first-page":"27","article-title":"Study of the binding capacity of FUT\u2010175 on dialysis membrane","volume":"20","author":"Nakagawa K","year":"1991","journal-title":"Jpn J Artif Organs"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00151-X"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.19.13.1042.31587"},{"key":"e_1_2_6_20_2","first-page":"233","volume-title":"Clinical Dialysis","author":"Amerling A","year":"1995"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.1998.06107.x"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2125.2004.02204.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2125.2004.02204.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:35:02Z","timestamp":1697427302000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2125.2004.02204.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,3]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1111\/j.1365-2125.2004.02204.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2125.2004.02204.x","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,3]]}}}