{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:44:47Z","timestamp":1765885487155},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T00:00:00Z","timestamp":1094169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the effectiveness of oral tincture of opium (TOP) and methadone to control opioid withdrawal in patients in northern Thailand.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Open label, parallel group study in an inpatient facility compared 15 former heroin users receiving methadone 5\u201320\u2003mg 12\u2003hourly with 15 former opium smokers receiving TOP (3.33\u201310\u2003mg morphine equivalents 12\u2003hourly). At 0, 1, 3 and 8\u2003h, blood, withdrawal scores and subjective opioid effects were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a reciprocal association between withdrawal scores\/direct subjective opioid effects and plasma (R)\u2010methadone, but not plasma morphine, concentrations. Withdrawal scores at the time of dosing were higher in the TOP patients (9.1\u2003\u00b1\u20033) than in the methadone patients (4.5\u2003\u00b1\u20034.6) and in the TOP patients were significantly (<jats:italic>P<\/jats:italic>\u2003=\u20030.001) attenuated at 3 and 8\u2003h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At the doses used, TOP was inferior to methadone in suppressing withdrawal. It could prove to be a cost effective and valuable drug, but only after dose size and frequency are further investigated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2125.2004.02209.x","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T16:42:52Z","timestamp":1099413772000},"page":"536-541","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of tincture of opium and methadone to control opioid withdrawal in a Thai treatment centre"],"prefix":"10.1111","volume":"58","author":[{"given":"Jaroon","family":"Jittiwutikarn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason M.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Bochner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew A.","family":"Somogyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J. 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