{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:16:26Z","timestamp":1767824186811,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p><jats:bold>Aims\u2003<\/jats:bold> The use of nonsteroidal anti\u2010inflammatory drugs (NSAIDs) in children has rapidly escalated over the last 5\u2003years in Australia. This is primarily as a result of the availability of ibuprofen as an over\u2010the\u2010counter preparation. Several recent, significant adverse drug reactions (ADRs) to NSAIDs, at the Royal Children's Hospital (RCH) in Melbourne, Australia prompted review of all of the RCH reactions reported to these agents over 5\u2003years.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> The ADR programme documents both spontaneously reported ADRs and ADRs identified by discharge coding. For this study, reported reactions to aspirin, celecoxib, ibuprofen, indomethacin, naproxen, paracetamol and rofecoxib, for the previous 5\u2010year period, were retrieved from the hospital ADR database.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Nineteen reports of ADRs to NSAIDs and six to paracetamol, in patients aged from 4\u2003months to 22\u2003years (median 10\u2003years) were identified. Reactions were predominantly rash (<jats:italic>n<\/jats:italic>\u2003=\u200310), gastrointestinal (<jats:italic>n<\/jats:italic>\u2003=\u20035) and respiratory (<jats:italic>n<\/jats:italic>\u2003=\u20034) side\u2010effects. These included reports of haematemesis with both celecoxib and ibuprofen. One patient died of severe acute exacerbation of asthma following initiation of rofecoxib.<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> NSAID exposures are a significant cause of morbidity in children. Both nonselective NSAIDs and the newer COX\u20102 inhibitors were associated with significant drug reactions. The overall severity of these ADRs highlights the need for vigilant surveillance of ADRs in paediatrics, including both established and newer agents.<\/jats:p>","DOI":"10.1111\/j.1365-2125.2005.02444.x","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T10:26:11Z","timestamp":1118312771000},"page":"718-723","source":"Crossref","is-referenced-by-count":78,"title":["Adverse drug reactions to nonsteroidal anti\u2010inflammatory drugs, COX\u20102 inhibitors and paracetamol in a paediatric hospital"],"prefix":"10.1111","volume":"59","author":[{"given":"Thirza","family":"Titchen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Cranswick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Beggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.18773\/austprescr.2004.051","article-title":"Ibuprofen use","volume":"27","author":"Beggs S","year":"2004","journal-title":"Aust Prescr"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1996.tb00001.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200427110-00005"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.6.462"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306-5251.2001.01407.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1001\/jama.1995.03520360043037","article-title":"An assessment of the safety of pediatric ibuprofen: a practitioner based randomized clinical trial","volume":"273","author":"Lesko SM","year":"1995","journal-title":"JAMA"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.4.e39"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.01138.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C391"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000069507.93582.6E"},{"key":"e_1_2_7_13_2","first-page":"2938","article-title":"Pseudoporphyria induced by celecoxib in a patient with juvenile rheumatoid arthritis","volume":"27","author":"Cummins R","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.6.713"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01075.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.6.1812"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10426"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.116290"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101113440215"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.6.2155"},{"key":"e_1_2_7_21_2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/jppr2003332106","article-title":"Adverse drug reactions in paediatrics: are we getting the full picture?","volume":"33","author":"Easton\u2010Carter KL","year":"2003","journal-title":"J Pharmacy Prac Res"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-003-1392-7"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2125.2005.02444.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2125.2005.02444.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T01:10:19Z","timestamp":1697418619000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2125.2005.02444.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1111\/j.1365-2125.2005.02444.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2125.2005.02444.x","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}