{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:05:12Z","timestamp":1790755512354,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T00:00:00Z","timestamp":1145577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Aims\u2002<\/jats:bold> \u03b2\u2010adrenergic agonists increase peripheral chemoreceptor sensitivity in humans. We tested the hypothesis that \u03b2<jats:sub>1<\/jats:sub>\u2010agonist\u2010related increase in peripheral chemoreflex sensitivity is selective and dose\u2010dependent.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Using a double\u2010blind, placebo\u2010controlled, randomized, crossover study, we examined the effects of dobutamine (<jats:italic>n<\/jats:italic>\u2003=\u200317\u2003healthy subjects) at perfusion rates of 2.5\u2003\u00b5g kg<jats:sup>\u22121<\/jats:sup>\u2003min<jats:sup>\u22121<\/jats:sup> (D2.5) and 7.5\u2003\u00b5g\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003min<jats:sup>\u22121<\/jats:sup> (D7.5) on ventilation, haemodynamics and sympathetic nerve activity during normoxia, isocapnic hypoxia, posthypoxic maximal voluntary end\u2010expiratory apnoea, hyperoxic hypercapnia and cold pressor test (CPT). We analysed the effect of pretreatment with atenolol on dobutamine\u2010evoked chemosensitivity.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Dobutamine dose\u2010dependently increased ventilation (placebo 6.7\u2003\u00b1\u20030.5 <jats:italic>vs.<\/jats:italic> D2.5 7.8\u2003\u00b1\u20030.4 <jats:italic>vs.<\/jats:italic> D7.5 8.7\u2003\u00b1\u20030.4\u2003l\u2003min<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.005) during normoxia, enhanced the ventilatory (placebo 14.4\u2003\u00b1\u20030.6 <jats:italic>vs.<\/jats:italic> D2.5 17.3\u2003\u00b1\u20030.8 <jats:italic>vs.<\/jats:italic> D7.5 22.5\u2003\u00b1\u20031.9\u2003l\u2003min<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001) and sympathetic (placebo +\u200a215\u2003\u00b1\u200331 <jats:italic>vs.<\/jats:italic> D2.5 +\u200a285\u2003\u00b1\u200319 <jats:italic>vs.<\/jats:italic> D7.5 +\u200a395\u2003\u00b1\u200350% of baseline, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.03) responses at the fifth minute of isocapnic hypoxia and enhanced the sympathetic response to apnoea performed after hypoxia (increase after 5\u2003min of hypoxia: +\u200a290\u2003\u00b1\u200343% for placebo <jats:italic>vs.<\/jats:italic>+\u200a360\u2003\u00b1\u200321% for D2.5 <jats:italic>vs.<\/jats:italic> 537\u2003\u00b1\u200369% for D7.5, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). No differences were observed between dobutamine and placebo in the responses to hyperoxic hypercapnia and CPT. Atenolol inhibited the dobutamine\u2010related hyperventilation and apnoea shortening during normoxia and hypoxia.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Dobutamine enhances peripheral chemosensitivity at low infusion rates selectively and in a dose\u2010dependent manner. There is a \u03b2<jats:sub>1<\/jats:sub> adrenoceptor component in dobutamine\u2010evoked increase in peripheral chemosensititivity; however, a contribution of additional adrenoceptor subtypes cannot be excluded.<\/jats:p>","DOI":"10.1111\/j.1365-2125.2006.02657.x","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T22:45:50Z","timestamp":1145659550000},"page":"272-279","source":"Crossref","is-referenced-by-count":22,"title":["Dose\u2010dependent effect of dobutamine on chemoreflex activity in healthy 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