{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:01:54Z","timestamp":1781359314901,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T00:00:00Z","timestamp":1145577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To describe how changes in legislation to restrict paracetamol sales have affected overdose discharges and death associated with the drug in Scotland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A descriptive analysis of routine death and hospital discharge data for the entire Scottish population between 1995 and 2004. Patients in Scotland participated who were discharged from hospital with a diagnosis of poisoning; deaths in Scotland from diagnosis of poisoning 1995\u20132003 were also analysed. Outcome measures were changes in mortality and overdose due to poisoning involving paracetamol. A comparison was made of in\u2010hospital and out\u2010of\u2010hospital mortality in fatalities involving paracetamol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of paracetamol\u2010associated deaths were due to co\u2010proxamol. Deaths associated with paracetamol alone or with ethanol occurred principally in hospital and were a minority of deaths overall. The proportion of in\u2010hospital deaths attributed to paracetamol increased (post\/pre ratio 1.347; 95% confidence interval 1.076, 1.639;<jats:italic>P<\/jats:italic>\u2003=\u20030.013). Overall numbers of cases discharged with poisoning fell. The proportion of these involving paracetamol in any form increased significantly in all groups except young men aged 10 to &lt;20\u2003years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Legislation has not reduced mortality or proportional use of paracetamol in overdose, both of which appear to have increased in Scotland since pack\u2010size limitations. Other approaches are necessary to reduce the death rate from overdoses involving paracetamol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2125.2006.02668.x","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T22:45:50Z","timestamp":1145659550000},"page":"573-581","source":"Crossref","is-referenced-by-count":39,"title":["Legislation restricting paracetamol sales and patterns of self\u2010harm and death from paracetamol\u2010containing preparations in Scotland"],"prefix":"10.1111","volume":"62","author":[{"given":"D. N.","family":"Bateman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"Gorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H. C.","family":"Inglis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. R.","family":"House","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,26]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/003693300404900408"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1177\/1478271520033304011","article-title":"Poisoning with paracetamol, ibuprofen and aspirin. How much is due to prescribed medication","volume":"33","author":"Sheen CL","year":"2003","journal-title":"J R Coll Physicians Edin"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg015"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1521\/suli.32.3.223.22169"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7296.1203"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02355-2"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7266.926"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02354-0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38253.572581.7C"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2002.t01-1-01671.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06663-6"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-3242-6"},{"key":"e_1_2_7_14_2","volume-title":"R: A Language and Environment for Statistical Computing.","author":"R Development Core Team."},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdh200"},{"key":"e_1_2_7_16_2","unstructured":"Committee on the Safety of Medicines.Available athttp:\/\/www.mhra.gov.uk2005(last accessed: March 2006)."},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.5694\/j.1326-5377.2003.tb05067.x","article-title":"The effect of recalling paracetamol on hospital admissions for poisoning in Western Australia","volume":"178","author":"Kisely SR","year":"2003","journal-title":"Med J Aust"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.5694\/j.1326-5377.2002.tb04346.x","article-title":"Paracetamol recall: a natural event influencing paracetamol poisoning","volume":"176","author":"Balit CR","year":"2002","journal-title":"Med J Aust"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mjt.0000140217.48324.e3"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01792.x"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2125.2006.02668.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2125.2006.02668.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T15:16:48Z","timestamp":1736349408000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2125.2006.02668.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,26]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1365-2125.2006.02668.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2125.2006.02668.x","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,26]]}}}