{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:39:14Z","timestamp":1783121954697,"version":"3.54.6"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,5,8]],"date-time":"2006-05-08T00:00:00Z","timestamp":1147046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>Non\u2010selective nonsteroidal anti\u2010inflammatory drugs (NSAIDs) have long been known to cause gastrointestinal and renal toxicity. More recently, adverse cardiovascular effects have been associated with the selective COX\u20102 inhibitors. However, current studies that show an increased cardiovascular risk with non\u2010selective NSAIDs raise the question of the exclusive contribution of COX\u20102 to this type of toxicity. Aldosterone, a key cardiovascular hormone, can induce deleterious effects, such as myocardial fibrosis and vascular stiffening. Non\u2010selective NSAIDs inhibit the metabolism of aldosterone <jats:italic>in vitro<\/jats:italic> by human renal tissue, predicating an increased plasma aldosterone concentration <jats:italic>in vivo<\/jats:italic>. The question remains whether inhibition of aldosterone metabolism by non\u2010selective NSAIDs is a casual or causal factor in NSAID\u2010induced cardiovascular toxicity.<\/jats:p>","DOI":"10.1111\/j.1365-2125.2006.02678.x","type":"journal-article","created":{"date-parts":[[2006,5,8]],"date-time":"2006-05-08T16:34:05Z","timestamp":1147106045000},"page":"738-740","source":"Crossref","is-referenced-by-count":33,"title":["Non\u2010selective nonsteroidal anti\u2010inflammatory drugs and cardiovascular events: is aldosterone the silent partner in crime?"],"prefix":"10.1111","volume":"61","author":[{"given":"Kathleen M.","family":"Knights","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arduino A.","family":"Mangoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John O.","family":"Miners","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,8]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7504.1366"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7504.1370"},{"key":"e_1_2_2_4_2","volume-title":"Increased Mortality Related to Treatment with Selective Cyclo\u2010oxygenase\u20102 Inhibitors and Non\u2010Steroidal Anti\u2010Inflammatory Drugs after Acute Myocardial Infarction.","author":"Gislason GH","year":"2006"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-3-17"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7563"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.025312"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00045415-200203000-00008"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411001"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030207"},{"key":"e_1_2_2_11_2","first-page":"P2","article-title":"In vitro glucuronidation of aldosterone by human liver and kidney cortical microsomes and recombinant UDP\u2010glucuronosyltransferase (UGT) 2B7: inhibition by non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs)","volume":"11","author":"Winner LK","year":"2005","journal-title":"Proc Aust Soc Clin Exp Pharmacol Toxicol"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2125.2006.02678.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2125.2006.02678.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T02:49:37Z","timestamp":1697424577000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2125.2006.02678.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,8]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1365-2125.2006.02678.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2125.2006.02678.x","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,8]]}}}