{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:54:02Z","timestamp":1772816042253,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T00:00:00Z","timestamp":1158624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate whether dorzolamide modifies peripapillary retinal haemodynamics in juvenile primary open\u2010angle glaucoma (JPOAG) patients treated with timolol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 40 JPOAG subjects, before and after dorzolamide coadministration with timolol, the following examinations were achieved: intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), heart rate (HR), visual field and retinal flowmetry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adjunctive therapy with dorzolamide induced the following modifications: IOP reduction [1.75\u2003mmHg, 95% confidence interval (CI) 1.23, 2.26; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05], OPP increase (5.09\u2003mmHg, 95% CI 2.97, 7.20; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.02) and retinal blood flow improvement (35.0 arbitrary units, 95% CI 12.20, 57.80; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.03). BP, HR and visual field indices did not change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dorzolamide, in association or in fixed combination with timolol, significantly improves retinal blood flow in JPOAG patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2125.2006.02768.x","type":"journal-article","created":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T09:41:33Z","timestamp":1158658893000},"page":"376-379","source":"Crossref","is-referenced-by-count":19,"title":["Effect of 2% dorzolamide on retinal blood flow: a study on juvenile primary open\u2010angle glaucoma patients already receiving 0.5% timolol"],"prefix":"10.1111","volume":"63","author":[{"given":"Ciro","family":"Costagliola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Campa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Parmeggiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Incorvaia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Perri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"D\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Lamberti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Sebastiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00008-3"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200522040-00004"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(99)00002-6"},{"key":"e_1_2_5_5_2","volume-title":"Terminology and Guidelines for Glaucoma","author":"European Glaucoma Society.","year":"2003"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.067637"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.09.001"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.11.1294"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.2.131"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200212000-00006"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.146.6.1073"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-004-0945-4"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2125.2006.02768.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2125.2006.02768.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:32:25Z","timestamp":1697430745000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2125.2006.02768.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,19]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1111\/j.1365-2125.2006.02768.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2125.2006.02768.x","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,19]]}}}