{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:52:10Z","timestamp":1792857130788,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T00:00:00Z","timestamp":1186617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p><jats:bold>WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT<\/jats:bold><\/jats:p><jats:p>\u2022\u2002Widow spider antivenoms, including redback spider antivenom, are often given by the intramuscular route.<\/jats:p><jats:p>\u2022\u2002No studies have measured widow spider antivenom following intramuscular or intravenous antivenom.<\/jats:p><jats:p><jats:bold>WHAT THIS STUDY ADDS<\/jats:bold><\/jats:p><jats:p>\u2022\u2002Intramuscular redback spider antivenom is not detectable in serum for at least 3\u20135\u2003h after treatment. Intravenous antivenom is detectable 30\u2003min after intravenous infusion.<\/jats:p><jats:p>\u2022\u2002Intramuscular antivenom may not be an effective administration route.<\/jats:p><jats:p><jats:bold>AIMS<\/jats:bold>There are no studies measuring antivenom concentrations following intramuscular administration. This study aimed to compare antivenom concentrations following intravenous and intramuscular administration of redback spider antivenom (RBSAV).<\/jats:p><jats:p><jats:bold>METHODS<\/jats:bold>Twenty patients recruited to a controlled trial comparing intramuscular and intravenous administration of antivenom had serial blood samples collected at 30\u2003min intervals for 2\u2003h after the administration of one or two doses of antivenom. Antivenom concentration was measured using an enzyme immunoassay.<\/jats:p><jats:p><jats:bold>RESULTS<\/jats:bold>Ten patients received intramuscular antivenom but antivenom could not be detected in serum after either one or two vials, at any time point. The median time of the final sample after commencement of antivenom treatment in these patients was 3.2\u2003h (1.8\u20135\u2003h). Ten patients received intravenous antivenom (three one vial and seven two or more vials) and antivenom was detected in all patients.<\/jats:p><jats:p><jats:bold>CONCLUSIONS<\/jats:bold>RBS AV given by the intramuscular route is unlikely to be effective in the treatment of redback (widow) spider bite.<\/jats:p>","DOI":"10.1111\/j.1365-2125.2007.03004.x","type":"journal-article","created":{"date-parts":[[2007,8,10]],"date-time":"2007-08-10T08:05:17Z","timestamp":1186733117000},"page":"139-143","source":"Crossref","is-referenced-by-count":28,"title":["A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom"],"prefix":"10.1111","volume":"65","author":[{"given":"Geoffrey K.","family":"Isbister","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"O'Leary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon G. 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