{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T17:15:00Z","timestamp":1723050900778},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T00:00:00Z","timestamp":1193184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:sec><jats:label \/><jats:p> <jats:bold>What is already known about this subject<\/jats:bold> <\/jats:p><jats:p>\u2022\u2002Danshen extract is widely used for the treatment and prevention of coronary heart disease and other diseases of senility in Asia.<\/jats:p><jats:p>\u2022\u2002Danshen extract and theophylline may be prescribed together to treat patients with asthma.<\/jats:p><jats:p>\u2022\u2002In human, theophylline with low therapeutic index is mainly metabolized by CYP1A2.<\/jats:p><jats:p>\u2022\u2002<jats:italic>In vitro<\/jats:italic> findings have shown that human CYP1A2 is inhibited by the ethyl acetate extract of danshen and danshen pharmaceutical product.<\/jats:p><jats:p>\u2022\u2002There may be drug interactions between danshen extract and theophylline (CYP1A2 substrate).<\/jats:p><jats:p> <jats:bold>What this study adds<\/jats:bold> <\/jats:p><jats:p>\u2022\u2002This study concerned drug interactions between danshen extract and theophylline in Chinese volunteers.<\/jats:p><jats:p>\u2022\u2002Long\u2010term oral intake of danshen extract does not change the basic pharmacokinetic parameters of theophylline.<\/jats:p><jats:p>\u2022\u2002Dose adjustment of theophylline thus may not be necessary in patients receiving concomitant therapy with danshen extract.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the potential effect of danshen extract on the pharmacokinetics of theophylline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a sequential cross\u2010over study with two phases, 12 volunteers took 100\u2003mg theophylline on day 1 and day 15. From day 2 to day 15, volunteers received danshen extract tablets three times daily, four tablets each time for 14\u2003days. On day 15, they received four danshen extract tablets with 100\u2003mg theophylline. Plasma concentrations of theophylline were measured on days 1 and 15 periodically for 24\u2003h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 90% confidence interval of <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>, <jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub> and CL\/<jats:italic>F<\/jats:italic> of theophylline with 14\u2010day danshen extract tablets <jats:italic>vs<\/jats:italic>. without comedication were (101.42, 121.36) (84.57, 106.72) and (88.82, 105.72), respectively. The time to peak plasma theophylline concentration was unchanged by danshen (P\u2003&gt;\u20030.05). The pharmacokinetics parameter of theophylline was unaffected by danshen extract.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Danshen extract does not influence the metabolism of theophylline in healthy volunteers. Dose adjustment of theophylline thus may not be necessary in patients receiving concurrent therapy with danshen extract tablets.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2125.2007.03027.x","type":"journal-article","created":{"date-parts":[[2007,10,27]],"date-time":"2007-10-27T05:21:22Z","timestamp":1193462482000},"page":"270-274","source":"Crossref","is-referenced-by-count":23,"title":["Effect of danshen extract on pharmacokinetics of theophylline in healthy 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