{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:34:15Z","timestamp":1782902055724,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,9,15]],"date-time":"2007-09-15T00:00:00Z","timestamp":1189814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:sec><jats:label\/><jats:p> <jats:bold>What is already known about this subject<\/jats:bold> <\/jats:p><jats:p>\u2022\u2002Furosemide is an effective diuretic, but its absorption may be too slow to allow oral treatment in certain patients.<\/jats:p><jats:p> <jats:bold>What this study adds<\/jats:bold> <\/jats:p><jats:p>\u2022\u2002In healthy volunteers, sublingual administration is associated with a higher <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>, a higher bioavailability and a more accentuated initial natriuretic response than oral furosemide. Sublingual administration may offer advantages over oral administration of furosemide in certain clinical situations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with decompensated heart failure, absorption of orally administered furosemide may be delayed, possibly leading to impaired pharmacodynamic effects. Sublingual administration may represent an alternative in such situations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a crossover study including 11 healthy men, 20\u2003mg furosemide was administered intravenously, orally and sublingually on three different days. Pharmacokinetics and pharmacodynamics were assessed from repeated blood and urine samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with oral administration, sublingual administration was associated with 43% higher <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>[difference 215\u2003ng\u2003ml<jats:sup>\u22121<\/jats:sup>, 95% confidence interval (CI) 37, 392], a higher urinary recovery (8.9 <jats:italic>vs.<\/jats:italic> 7.3\u2003mg, difference 1.6\u2003mg, 95% CI 0.3, 2.9), an 28% higher AUC (difference 328\u2003ng\u2003h<jats:sup>\u22121<\/jats:sup>\u2003ml<jats:sup>\u22121<\/jats:sup>, 95% CI 24, 632) and a higher bioavailability of furosemide (59 <jats:italic>vs.<\/jats:italic> 47%, difference 12.0%, 95% CI \u22121.2, 25.2). Sodium excretion was higher after sublingual compared with oral administration (peak excretion rate 1.8 <jats:italic>vs.<\/jats:italic> 1.4\u2003mmol\u2003min<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), whereas urine volume did not differ significantly between the two application modes. In comparison, intravenous administration showed the expected more rapid and intense response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sublingually administered furosemide tablets differ in certain kinetic and dynamic properties from identical tablets given orally. Sublingual administration of furosemide may offer therapeutic advantages in certain groups of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2125.2007.03035.x","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T06:10:27Z","timestamp":1190095827000},"page":"804-809","source":"Crossref","is-referenced-by-count":31,"title":["Sublingual administration of furosemide: new application of an old drug"],"prefix":"10.1111","volume":"64","author":[{"given":"Laurent","family":"Haegeli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Peter","family":"Brunner\u2010La Rocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Wenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Pfisterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Drewe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kr\u00e4henb\u00fchl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi204"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198530050-00003"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.153"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1982.149"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9236(95)90222-8"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-3-314"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01059061"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01059086"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00556898"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00630286"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1996.00494.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1997.tb03681.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2006.02.025"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241090-00003"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2125.2007.03035.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2125.2007.03035.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:33:27Z","timestamp":1697441607000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2125.2007.03035.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,15]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1111\/j.1365-2125.2007.03035.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2125.2007.03035.x","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,15]]}}}