{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:11:57Z","timestamp":1791130317482,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,12,18]],"date-time":"2007-12-18T00:00:00Z","timestamp":1197936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:sec><jats:label\/><jats:p> <jats:bold>WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT<\/jats:bold> <\/jats:p><jats:p>\u2022\u2003The risk of adverse events due to chronic benzodiazepine use is high in the elderly.<\/jats:p><jats:p>\u2022\u2003Cross\u2010sectional studies have shown that increasing age, female gender and poor physical and mental health are associated with benzodiazepine use.<\/jats:p><jats:p>\u2022\u2003When users were re\u2010examined some years later, chronic somatic disease, pain and stress seemed to contribute to the continuation of benzodiazepine use.<\/jats:p><jats:p> <jats:bold>WHAT THIS STUDY ADDS<\/jats:bold> <\/jats:p><jats:p>\u2022\u2003This is the first longitudinal study that analyzed the determinants of new\u2010onset chronic benzodiazepine use in community\u2010dwelling elderly.<\/jats:p><jats:p>\u2022\u2003Symptoms of depression, hypertension, pain related joint complaints and the perception of poor physical health predicted new\u2010onset chronic use. Living alone was found to decrease the risk of chronic use.<\/jats:p><\/jats:sec><jats:sec><jats:title>AIMS<\/jats:title><jats:p>The risk of adverse events due to chronic benzodiazepine use is high in the elderly. Clinicians need to be able to identify those persons who are at risk of chronic benzodiazepine use, but little is known about the determinants. This study determined social and health related factors that predict new\u2010onset chronic benzodiazepine use in community\u2010dwelling elderly.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This study was embedded in an ongoing cohort study among 5364 persons aged \u226557\u2003years. Drug\u2010dispensing medication records were available for the period between 1991 and 2003. We defined chronic benzodiazepine use as use during at least 180\u2003days in a period of 365 consecutive days. The association of various social, psychiatric and somatic variables with new\u2010onset chronic benzodiazepine use was studied with a Cox proportional hazards analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Symptoms of depression, hypertension, pain related joint complaints and the perception of poor physical health predicted new\u2010onset chronic use. In the subsample of participants who had filled at least one prescription in the follow\u2010up period, of these variables only pain related joint complaints increased the risk of new\u2010onset chronic use. Living alone protected against chronic benzodiazepine use.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The elderly with poor mental and physical health are at an increased risk of chronic benzodiazepine use. Living alone was found to decrease the risk of chronic use, which suggests that social factors may determine drug usage patterns. Very few characteristics predicted chronic benzodiazepine use once patients had received their first prescription. For clinicians, identification of patients at high risk is therefore not straightforward.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2125.2007.03060.x","type":"journal-article","created":{"date-parts":[[2008,3,11]],"date-time":"2008-03-11T10:26:26Z","timestamp":1205231186000},"page":"593-599","source":"Crossref","is-referenced-by-count":70,"title":["Determinants of chronic benzodiazepine use in the elderly: A longitudinal study"],"prefix":"10.1111","volume":"65","author":[{"given":"Hendrika J.","family":"Luijendijk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Tiemeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hofman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Heeringa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno H. 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