{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:38:34Z","timestamp":1789594714286,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T00:00:00Z","timestamp":1221782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:sec><jats:label\/><jats:p> <jats:bold>WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT<\/jats:bold> <\/jats:p><jats:p>\u2022\u2003Dopamine agonists used in Parkinson's disease patients are associated with excessive daytime sleepiness and sleep attacks occurring without prior warning.<\/jats:p><jats:p>\u2022\u2003Parkinson's disease accounts in itself for a variety of sleep disorders. It is therefore important to study the drug\u2010induced sleepiness in healthy volunteers.<\/jats:p><jats:p>\u2022\u2003In healthy subjects, pramipexole has proved to decrease alertness and ropinirole to reduce sleep latency.<\/jats:p><jats:p> <jats:bold>WHAT THIS STUDY ADDS<\/jats:bold> <\/jats:p><jats:p>\u2022\u2003Results from our study show that pramipexole reduces the mean sleep latency as measured by the Multiple Sleep Latency Test in healthy volunteers, hence providing an objective measure of increased sleepiness.<\/jats:p><jats:p>\u2022\u2003Furthermore, the reduction in sleep latency was not associated with a subjective impression of increased sleepiness.<\/jats:p><jats:p>\u2022\u2003Such dissociation may underlie the occurrence of sleep attacks without prior warning.<\/jats:p><\/jats:sec><jats:sec><jats:title>AIMS<\/jats:title><jats:p>To assess the sleepiness induced by pramipexole, a D2\/D3\u2010dopamine receptor agonist commonly used in Parkinson's disease and restless legs syndrome, without the problem of the confounding factors related to the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Placebo, bromocriptine (2.5\u2003mg), L\u2010dopa (100\u2003mg) and pramipexole (0.5\u2003mg) were administered in a single oral dose on four separate days, with at least a 2\u2010week wash\u2010out period in a randomized cross\u2010over design. Induced somnolence was assessed using Multiple Sleep Latency Test (MSLT) and subjective scaling of vigilance. Twelve male subjects (26.3\u2003\u00b1\u20035.5 years old) without anxiety, mood, sleep or sedation disorders were enrolled.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Pramipexole significantly reduced mean sleep latency compared with placebo 3\u2003h 30\u2003min [\u22126.1\u2003min (\u22129.8, \u22122.4), <jats:italic>P<\/jats:italic>\u2003=\u20030.002] and 5\u2003h 30\u2003min [\u22125.6\u2003min (\u22127.7, \u22123.5), <jats:italic>P<\/jats:italic>\u2003=\u20030.003] after administration. In addition, the total duration of sleep during the tests was higher with pramipexole than with placebo [+6.0\u2003min (2.3, 9.7), <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001]. These differences were not observed with L\u2010dopa and bromocriptine in comparison with placebo. The induced sleepiness was not associated with an increase in subjective somnolence scaling, indicating that this adverse event may occur without prior warning.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>These results show that a single oral dose of pramipexole induces sleepiness as assessed by MSLT in healthy young subjects, independent of disease\u2010related sleep dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2125.2008.03310.x","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T10:38:18Z","timestamp":1221820698000},"page":"333-340","source":"Crossref","is-referenced-by-count":56,"title":["Antiparkinsonian drug\u2010induced sleepiness: a double\u2010blind placebo\u2010controlled study of L\u2010dopa, bromocriptine and pramipexole in healthy 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