{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T10:10:24Z","timestamp":1793700624989,"version":"4.5.1"},"reference-count":152,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T00:00:00Z","timestamp":1315526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>Thrombogenic and inflammatory activity are two distinct aspects of platelet biology, which are sustained by the ability of activated platelets to interact with each other (homotypic aggregation) and to adhere to circulating leucocytes (heterotypic aggregation). These two events are regulated by distinct biomolecular mechanisms that are selectively activated in different pathophysiological settings. They can occur simultaneously, for example, as part of a pro\u2010thrombotic\/pro\u2010inflammatory response induced by vascular damage, or independently, as in certain clinical conditions in which abnormal heterotypic aggregation has been observed in the absence of intravascular thrombosis. Current antiplatelet drugs have been developed to target specific molecular signalling pathways mainly implicated in thrombus formation, and their ever increasing clinical use has resulted in clear benefits in the treatment and prevention of arterial thrombotic events. However, the efficacy of currently available antiplatelet drugs remains suboptimal, most likely because their therapeutic action is limited to only few of the signalling pathways involved in platelet homotypic aggregation. In this context, modulation of heterotypic aggregation, which is believed to contribute importantly to acute thrombotic events, as well to the pathophysiology of atherosclerosis itself, may offer benefits over and above the classical antiplatelet approach. This review will focus on the distinct biomolecular pathways that, following platelet activation, underlie homotypic and heterotypic aggregation, aiming potentially to identify novel therapeutic targets.<\/jats:p>","DOI":"10.1111\/j.1365-2125.2011.03906.x","type":"journal-article","created":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T18:35:46Z","timestamp":1294770946000},"page":"604-618","source":"Crossref","is-referenced-by-count":20,"title":["Current concepts of platelet activation: possibilities for therapeutic modulation of heterotypic <i>vs.<\/i> homotypic aggregation"],"prefix":"10.1111","volume":"72","author":[{"given":"Gabriella","family":"Passacquale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,9]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81607-4"},{"key":"e_1_2_9_3_2","first-page":"296","article-title":"Decreased adhesion of platelet to subendothelium in von Willebrand's disease","volume":"83","author":"Tschopp TB","year":"1973","journal-title":"J Lab Clin Med"},{"key":"e_1_2_9_4_2","first-page":"750","article-title":"Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate\u2010dependent decrease of adhesion in von Willebrand's disease and the Bernard\u2010Soulier syndrome","volume":"92","author":"Weiss HJ","year":"1978","journal-title":"J Lab Clin Med"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.104.6.1655"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1989.69.1.58"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0205-1"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.5.1525.1525"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000017140.26466.F5"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3801.095588"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000015700.27754.6F"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01485-1"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000228710"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03101.x"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2001.00359.x"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2002.t01-1-00433.x"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp330"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000127128.52679.E4"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.05.008"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2003.13"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26987"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm810"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0708400"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7569"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-028282"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80983-6"},{"key":"e_1_2_9_27_2","first-page":"211","article-title":"Platelet adhesion","volume":"7","author":"Packham MA","year":"1984","journal-title":"Prog Hemost Thromb"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-011551"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110448"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80622-4"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657598"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9896"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30537"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02116.x"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01344-X"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.051"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-07-0415"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608207103"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01931360"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06036.x"},{"key":"e_1_2_9_42_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0735-1097(96)00164-7","article-title":"Leukocyte activation with platelet adhesion after coronary angioplasty: a mechanism for recurrent disease","volume":"28","author":"Mickelson JK","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000252802.25497.b7"},{"key":"e_1_2_9_44_2","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1182\/blood.V78.7.1730.1730","article-title":"Dynamics of leukocyte\u2013platelet adhesion in whole blood","volume":"78","author":"Rinder HM","year":"1991","journal-title":"Blood"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537100310001638562"},{"key":"e_1_2_9_46_2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1182\/blood.V67.3.629.629","article-title":"Platelet\u2013leukocyte interaction: selective binding of thrombin\u2010stimulated platelets to human monocytes, polymorphonuclear leukocytes, and related cell lines","volume":"67","author":"Jungi TW","year":"1986","journal-title":"Blood"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.7.1760.1760"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.3.550.550"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90292-4"},{"key":"e_1_2_9_50_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0037-1614407","article-title":"The biology of P\u2010selectin glycoprotein ligand\u20101: its role as a selectin counterreceptor in leukocyte\u2013endothelial and leukocyte\u2013platelet interaction","volume":"81","author":"Yang J","year":"1999","journal-title":"Thromb Haemost"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03179.x"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.56.5.583"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.45.28750"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00420-X"},{"key":"e_1_2_9_55_2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.4049\/jimmunol.158.3.1061","article-title":"T cell adhesion to P\u2010selectin induces tyrosine phosphorylation of pp125 focal adhesion kinase and other substrates","volume":"158","author":"Haller H","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1491"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0708400"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.7.2313"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(89)69070-2"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1977.tb41767.x"},{"key":"e_1_2_9_61_2","first-page":"1","article-title":"Interaction of microtubules and microfilaments in platelet contractile physiology","volume":"9","author":"White JG","year":"1979","journal-title":"Methods Achiev Exp Pathol"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.98.6.2019"},{"key":"e_1_2_9_63_2","first-page":"3334","article-title":"Molecular mechanisms of platelet exocytosis: insights into the \u2018secrete\u2019 life of thrombocytes","volume":"96","author":"Reed GL","year":"2000","journal-title":"Blood"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000075965.88456.48"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328309ec74"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(84)90781-X"},{"key":"e_1_2_9_67_2","first-page":"1483","article-title":"Differential effects of cytochalasin B on platelet release, aggregation and contractility: evidence against a contractile mechanism for the release of platelet granular contents","volume":"42","author":"Kirkpatrick JP","year":"1980","journal-title":"Thromb Haemost"},{"key":"e_1_2_9_68_2","first-page":"194","article-title":"Role of actin in platelet function","volume":"62","author":"Lefebvre P","year":"1993","journal-title":"Eur J Cell Biol"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.2.474.474"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(88)90454-8"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)91094-6"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1392"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-270934"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-268680"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02698.x"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-113837"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.675991"},{"key":"e_1_2_9_78_2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1182\/blood.V82.2.505.505","article-title":"Aspirin does not inhibit adenosine diphosphate\u2010induced platelet a\u2010granule release","volume":"82","author":"Rinder CS","year":"1993","journal-title":"Blood"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2003.08.026"},{"key":"e_1_2_9_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00817-2"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.900589"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.11.1537"},{"key":"e_1_2_9_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09457-3"},{"key":"e_1_2_9_84_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050522"},{"key":"e_1_2_9_85_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.10.1224"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16721-4"},{"key":"e_1_2_9_87_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1385"},{"key":"e_1_2_9_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100139"},{"key":"e_1_2_9_89_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706482"},{"key":"e_1_2_9_90_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-869525"},{"key":"e_1_2_9_91_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-010-0363-z"},{"key":"e_1_2_9_92_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613242"},{"key":"e_1_2_9_93_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-05-0313"},{"key":"e_1_2_9_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.01.367"},{"key":"e_1_2_9_95_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000251742.71301.16"},{"key":"e_1_2_9_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(97)80058-0"},{"key":"e_1_2_9_97_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3320281"},{"key":"e_1_2_9_98_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.41.29108"},{"key":"e_1_2_9_99_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20020226"},{"key":"e_1_2_9_100_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004204200"},{"key":"e_1_2_9_101_2","first-page":"399","article-title":"PKCalpha regulates platelet granule secretion and thrombus formation in mice","volume":"119","author":"Konopatskaya O","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_9_102_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306960200"},{"key":"e_1_2_9_103_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.136176"},{"key":"e_1_2_9_104_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301838200"},{"key":"e_1_2_9_105_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.41.29108"},{"key":"e_1_2_9_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/35051599"},{"key":"e_1_2_9_107_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.24.15113"},{"key":"e_1_2_9_108_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2320373"},{"key":"e_1_2_9_109_2","doi-asserted-by":"crossref","first-page":"14509","DOI":"10.1016\/S0021-9258(17)36652-8","article-title":"cAMP and cGMP\u2010dependent protein kinase [hosphorylation sites of the focal vasodilator\u2010stimulated phosphoprotein (VASP) in vitro in intact human plateltes","volume":"269","author":"Butt E","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_9_110_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401532200"},{"key":"e_1_2_9_111_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.219501"},{"key":"e_1_2_9_112_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1970.tb09903.x"},{"key":"e_1_2_9_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(96)00035-9"},{"key":"e_1_2_9_114_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197809072991002"},{"key":"e_1_2_9_115_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202212200"},{"key":"e_1_2_9_116_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.14.1.77"},{"key":"e_1_2_9_117_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000141527.60441.B7"},{"key":"e_1_2_9_118_2","doi-asserted-by":"publisher","DOI":"10.3109\/09537101003718065"},{"key":"e_1_2_9_119_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10881"},{"key":"e_1_2_9_120_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3601.094003"},{"key":"e_1_2_9_121_2","article-title":"PGE(1) and PGE(2) modify platelet function through different prostanoid receptors","author":"Iy\u00fa D","year":"2010","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"e_1_2_9_122_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.1.39"},{"key":"e_1_2_9_123_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408310102"},{"key":"e_1_2_9_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.05.021"},{"key":"e_1_2_9_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01254-0"},{"key":"e_1_2_9_126_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3210"},{"key":"e_1_2_9_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(00)00415-1"},{"key":"e_1_2_9_128_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537100410001715583"},{"key":"e_1_2_9_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.05.032"},{"key":"e_1_2_9_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-9842(03)00005-9"},{"key":"e_1_2_9_131_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03278.x"},{"key":"e_1_2_9_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00031-6"},{"key":"e_1_2_9_133_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.11.020"},{"key":"e_1_2_9_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.01.006"},{"key":"e_1_2_9_135_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002130.pub2"},{"key":"e_1_2_9_136_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421803"},{"key":"e_1_2_9_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)11179-6"},{"key":"e_1_2_9_138_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.13.1727"},{"key":"e_1_2_9_139_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2391"},{"key":"e_1_2_9_140_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3242"},{"key":"e_1_2_9_141_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0308"},{"key":"e_1_2_9_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.01.023"},{"key":"e_1_2_9_143_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808563200"},{"key":"e_1_2_9_144_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2007.12.005"},{"key":"e_1_2_9_145_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.6.2976"},{"key":"e_1_2_9_146_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03459.x"},{"key":"e_1_2_9_147_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.724864"},{"key":"e_1_2_9_148_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214996"},{"key":"e_1_2_9_149_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10741"},{"key":"e_1_2_9_150_2","doi-asserted-by":"crossref","first-page":"H2124","DOI":"10.1152\/ajpheart.1994.267.6.H2124","article-title":"Sialyl Lewisx\u2010containing oligosaccharide exerts beneficial effects in murine traumatic shock","volume":"267","author":"Skurk C","year":"1994","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"e_1_2_9_151_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.9.5271"},{"key":"e_1_2_9_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00266-1"},{"key":"e_1_2_9_153_2","doi-asserted-by":"publisher","DOI":"10.1089\/oli.1.1998.8.265"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2125.2011.03906.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2125.2011.03906.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T13:14:05Z","timestamp":1694610845000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2125.2011.03906.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,9]]},"references-count":152,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1111\/j.1365-2125.2011.03906.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2125.2011.03906.x","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,9]]}}}