{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:36:37Z","timestamp":1783683397973,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T00:00:00Z","timestamp":1323302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT<\/jats:bold><\/jats:p><jats:p>\u2022\u2003The intradermal capsaicin model of neuropathic pain has been previously developed and used in healthy volunteers.<\/jats:p><jats:p>\u2022\u2003Few previous studies have used this model in pain patients.<\/jats:p><jats:p><jats:bold>WHAT THIS STUDY ADDS<\/jats:bold><\/jats:p><jats:p>\u2022\u2003We have compared the response to intradermal capsaicin in the painful and nonpainful legs of patients with unilateral sciatica and compared these with healthy, pain\u2010free control subjects. Pain and hyperalgesia responses were enhanced in both legs of patients with unilateral sciatica compared with healthy controls. The time course of hyperalgesia was different in sciatica patients, demonstrating a slower and larger evolution.<\/jats:p><jats:p>\u2022\u2003Qualitative and quantitative differences between pain patients and healthy controls suggest that the use of a neuropathic pain model such as intradermal capsaicin to screen for novel antineuropathic agents might be superior in patients with pre\u2010existing neuropathic pain syndromes.<\/jats:p><\/jats:sec><jats:sec><jats:title>AIM<\/jats:title><jats:p>This study compared the responses between patients with unilateral sciatica and pain\u2010free volunteers following administration of intradermal capsaicin.<\/jats:p><jats:p><jats:bold>METHODS<\/jats:bold> Fourteen patients with unilateral sciatica and 12 pain\u2010free volunteers received one injection per hour over 4\u2003h of 1\u2003\u00b5g and 10\u2003\u00b5g capsaicin, into each calf. For each dose, spontaneous pain (10\u2003cm VAS), area of flare (cm<jats:sup>2<\/jats:sup>) and the sum of allodynia and hyperalgesia radii across eight axes (cm) were recorded pre\u2010injection and at 5, 15, 30, 45 and 60\u2003min post injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Sciatica subjects experienced higher spontaneous pain and hyperalgesia responses in both legs compared with pain\u2010free volunteers. The largest mean difference in spontaneous pain was 2.8\u2003cm (95% CI 1.6, 3.9) at 5\u2003min in the unaffected leg following 10\u2003\u00b5g. The largest mean difference in hyperalgesia was 19.7\u2003cm (95% CI 12.4, 27.0) at 60\u2003min in the unaffected leg following 10\u2003\u00b5g. Allodynia was greater in patients than in controls with the largest mean difference of 2.9\u2003cm (95% CI 1, 4.8) at 5\u2003min following 10\u2003\u00b5g in the affected leg. Allodynia was also higher in the affected leg compared with the unaffected leg in sciatica patients with the highest mean difference of 3.0\u2003cm (95% CI 1.2, 4.7) at 5\u2003min following 10\u2003\u00b5g.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The responses to intradermal capsaicin are quantitatively and qualitatively different in unilateral sciatica patients compared with pain\u2010free controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2125.2011.04059.x","type":"journal-article","created":{"date-parts":[[2011,7,11]],"date-time":"2011-07-11T04:27:11Z","timestamp":1310358431000},"page":"37-45","source":"Crossref","is-referenced-by-count":13,"title":["Intradermal capsaicin as a neuropathic pain model in patients with unilateral 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