{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T09:07:11Z","timestamp":1772183231967,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T00:00:00Z","timestamp":1341878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:bold>WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT<\/jats:bold><\/jats:p><jats:p>\u2022\u2003Antidepressants represent one of the most commonly used medications during pregnancy.<\/jats:p><jats:p>\u2022\u2003There is a scarcity of information on impact of medications on maternal health outcomes.<\/jats:p><jats:p>\u2022\u2003As the primary caregiver of the child, the mother's health and well\u2010being should carry significant weight when making decisions regarding medication use during pregnancy.<\/jats:p><jats:p><jats:bold>WHAT THIS STUDY ADDS<\/jats:bold><\/jats:p><jats:p>\u2022\u2003Antidepressant use during pregnancy is associated with increased risk of pregnancy\u2010induced hypertension.<\/jats:p><jats:p>\u2022\u2003These findings highlight the importance of further research evaluating the impact of gestational medication use on the health of the mother.<\/jats:p><jats:p><jats:bold>AIM<\/jats:bold> Due to their effect on altering physiological interactions between vasodilator and vasoconstrictor autacoids in normal pregnancies, antidepressants may be associated with the risk of pregnancy\u2010induced hypertension. We evaluated the impact of antidepressant use during pregnancy on the risk of pregnancy\u2010induced hypertension.<\/jats:p><jats:p><jats:bold>METHODS<\/jats:bold> We conducted a nested case\u2013control study within the Quebec Pregnancy Registry, built by linkage of provincial medical, pharmaceutical, hospital and birth databases. We identified 1216 women with a diagnosis of pregnancy\u2010induced hypertension with or without pre\u2010eclampsia and with no history of hypertension before pregnancy. We randomly selected 10 controls for each case, matched on case index date (date of diagnosis) and gestational age. Odds ratios (OR) were calculated using conditional logistic regression models, adjusting for sociodemographic characteristics, maternal depression, anxiety, other chronic conditions, medication use and health service utilization.<\/jats:p><jats:p><jats:bold>RESULTS<\/jats:bold> Among cases, 45 (3.7%) had used antidepressants during pregnancy compared with 300 (2.5%) in the control group (OR 1.52, 95% CI 1.10, 2.09). After adjusting for potential confounders, use of antidepressants during pregnancy was significantly associated with increased risk of pregnancy\u2010induced hypertension (OR 1.53, 95% CI 1.01, 2.33). In stratified analyses, use of selective serotonin re\u2010uptake inhibitors (OR 1.60, 95% CI 1.00, 2.55), and more specifically, paroxetine (OR 1.81, 95% CI 1.02, 3.23) was associated with risk of pregnancy\u2010induced hypertension.<\/jats:p><jats:p><jats:bold>CONCLUSIONS<\/jats:bold> Women who use antidepressants during pregnancy are at increased risk of pregnancy\u2010induced hypertension with or without pre\u2010eclampsia above and beyond the risk that could be attributed to their depression or anxiety disorders.<\/jats:p>","DOI":"10.1111\/j.1365-2125.2012.04196.x","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T01:58:06Z","timestamp":1332467886000},"page":"362-369","source":"Crossref","is-referenced-by-count":55,"title":["Antidepressant use during pregnancy and the risk of pregnancy\u2010induced hypertension"],"prefix":"10.1111","volume":"74","author":[{"given":"Mary A.","family":"De 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