{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:59:10Z","timestamp":1789009150933,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2013,4]]},"abstract":"\n Aims<\/jats:title>\n We aimed to explore associations between drugs dispensed to the father prior to conception and pregnancy outcomes, such as pre\u2010term birth, perinatal mortality, foetal growth retardation and birth defects.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this cohort study, two population\u2010based registries, the\n M<\/jats:styled-content>\n edical\n B<\/jats:styled-content>\n irth\n R<\/jats:styled-content>\n egistry of\n N<\/jats:styled-content>\n orway and the\n N<\/jats:styled-content>\n orwegian\n P<\/jats:styled-content>\n rescription\n D<\/jats:styled-content>\n atabase, were linked. The study cohort consisted of 340\u2009000 pregnancies in 2004\u201310. The association between specific drugs dispensed to the fathers during the last 3 months prior to conception and pregnancy outcomes was explored by estimating odds ratios (\n ORs<\/jats:styled-content>\n ) using multivariate logistic regression.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n About one quarter (26%) of the fathers were dispensed at least one drug during the last 3 months prior to conception and 1.3% were dispensed at least one drug requiring special attention. Overall, the odds of different adverse pregnancy outcomes were not increased when the father had been dispensed drugs, i.e. the\n OR<\/jats:styled-content>\n and 95% confidence intervals (\n CIs<\/jats:styled-content>\n ) for any birth defect when the fathers had been dispensed any drug were 0.99 (0.94, 1.0). When the fathers had been dispensed diazepam we found increased risk of perinatal mortality and growth retardation, with\n OR<\/jats:styled-content>\n and 95%\n CIs<\/jats:styled-content>\n of 2.2 (1.2, 3.9) and 1.4 (1.2, 1.6), respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Large studies are necessary to reveal increased risk of rare outcomes as specific birth defects. Our study did not indicate that paternal drug exposure is an important risk factor for adverse pregnancy outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1365-2125.2012.04426.x","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T07:35:11Z","timestamp":1345188911000},"page":"1134-1141","source":"Crossref","is-referenced-by-count":50,"title":["Effects of preconceptional paternal drug exposure on birth outcomes: cohort study of 340\u2009000 pregnancies using\n N<\/scp>\n orwegian population\u2010based databases"],"prefix":"10.1111","volume":"75","author":[{"given":"Anders","family":"Engeland","sequence":"first","affiliation":[{"name":"Department of Pharmacoepidemiology Division of Epidemiology Norwegian Institute of Public Health Oslo Norway"},{"name":"Department of Public Health and Primary Health Care University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tone","family":"Bj\u00f8rge","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Health Care University of Bergen Bergen Norway"},{"name":"Medical Birth Registry of Norway Division of Epidemiology Norwegian Institute of Public Health Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Kjersti","family":"Daltveit","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Health Care University of Bergen Bergen Norway"},{"name":"Medical Birth Registry of Norway Division of Epidemiology Norwegian Institute of Public Health Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Skurtveit","sequence":"additional","affiliation":[{"name":"Department of Pharmacoepidemiology Division of Epidemiology Norwegian Institute of Public Health Oslo Norway"},{"name":"Norwegian Centre for Addictive Research University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siri","family":"Vangen","sequence":"additional","affiliation":[{"name":"Unit Rikshospitalet National Resource Centre for Women's Health Oslo University Hospital Oslo Norway"},{"name":"Department of Chronic Diseases Division of Epidemiology Norwegian Institute of Public Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein Emil","family":"Vollset","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Health Care University of Bergen Bergen Norway"},{"name":"Norwegian Institute of Public Health Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Furu","sequence":"additional","affiliation":[{"name":"Department of Pharmacoepidemiology Division of Epidemiology Norwegian Institute of Public Health Oslo Norway"},{"name":"Department of Pharmacy University of Troms\u00f8 Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2008.06.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gap087"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.04.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2008.01109.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03179.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.959"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03102.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2010.01.008"},{"key":"e_1_2_8_10_1","first-page":"129","article-title":"Establishment of the nationwide Norwegian Prescription Database (NorPD) \u2013 new opportunities for research in pharmacoepidemiology in Norway","volume":"18","author":"Furu K","year":"2008","journal-title":"Nor J Epidemiol"},{"key":"e_1_2_8_11_1","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology.WHO collaborating centre for drug statistics methodology.2010. 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