{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:09:29Z","timestamp":1790521769242,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the influence of hospital drug choices on pharmaceutical consumption for nine competitive classes in the surrounding community.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ecological study. Data from the national survey on drugs in hospitals were used to extract quantities purchased by 25 French university hospitals for three \u2018hospital classes\u2019 (<jats:styled-content style=\"fixed-case\">EPOs<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">LMWHs<\/jats:styled-content> and setrons) and six \u2018ambulatory classes\u2019 (<jats:styled-content style=\"fixed-case\">PPIs<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">ACEIs<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ARBs<\/jats:styled-content>, statins, \u03b1\u2010adrenoreceptor antagonists (<jats:styled-content style=\"fixed-case\">AAAs<\/jats:styled-content>) and selective serotonin re\u2010uptake inhibitors <jats:styled-content style=\"fixed-case\">SSRIs<\/jats:styled-content>). Re\u2010imbursed quantities for patients living in the hospital's catchment area were extracted from the national health insurance database. The relationship between the use of a brand in hospitals and their catchment areas was assessed using multivariate linear regressions with instrumental variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An increase of 1 day of treatment with one brand in the hospital was associated with a significant increase of 2.8 days of treatment with the same brand in the catchment area. However, results strongly varied according to classes. An increase of 1 day of treatment in the hospital was significantly associated with an increase of 0.21 day for \u2018hospital classes\u2019 and 21.8 days for \u2018ambulatory classes\u2019 in the catchment area. Strong variations were seen across \u2018ambulatory classes\u2019. The effect was maximal for cardiovascular classes and not significant for <jats:styled-content style=\"fixed-case\">AAAs<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SSRIs<\/jats:styled-content>. The size of the effect also varied with hospital characteristics: small and proximity university hospitals exerted the greatest influence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hospital consumption influences the use of drugs in the community. A significant effect was found, especially for competitive classes used on a long\u2010term basis. The economic consequences of these findings need to be addressed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2125.2012.04455.x","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T12:29:16Z","timestamp":1347020956000},"page":"1142-1148","source":"Crossref","is-referenced-by-count":10,"title":["The influence of drug use in university hospitals on the pharmaceutical consumption in their surrounding communities"],"prefix":"10.1111","volume":"75","author":[{"given":"Adeline","family":"Gallini","sequence":"first","affiliation":[{"name":"Epid\u00e9miologie et analyses en sant\u00e9 publique INSERM, UMR 1027  Toulouse France"},{"name":"UPS Toulouse 3 Universit\u00e9 de Toulouse  Toulouse France"},{"name":"Service d'Epid\u00e9miologie CHU de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Legal","sequence":"additional","affiliation":[{"name":"Direction de la recherche, des \u00e9tudes, de l'\u00e9valuation et des statistiques (DREES) Minist\u00e8res charg\u00e9s de la sant\u00e9, des solidarit\u00e9s et des comptes publics  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Taboulet","sequence":"additional","affiliation":[{"name":"Epid\u00e9miologie et analyses en sant\u00e9 publique INSERM, UMR 1027  Toulouse France"},{"name":"UPS Toulouse 3 Universit\u00e9 de Toulouse  Toulouse France"},{"name":"Laboratoire de droit pharmaceutique et d'\u00e9conomie de la sant\u00e9 Universit\u00e9 de Toulouse, UPS Toulouse 3, Facult\u00e9 des sciences pharmaceutiques  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050121"},{"key":"e_1_2_9_3_1","first-page":"122","article-title":"Hospital initiated prescribing in the General Medical Services scheme","volume":"86","author":"Fahey T","year":"1993","journal-title":"Ir Med J"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2001.tb143645.x"},{"key":"e_1_2_9_5_1","first-page":"573","article-title":"The influence of specialists on prescribing by GPs. 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