{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:51:22Z","timestamp":1785883882106,"version":"3.56.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2834,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1111\/j.1365-2133.2007.08329.x","type":"journal-article","created":{"date-parts":[[2010,7,21]],"date-time":"2010-07-21T14:11:01Z","timestamp":1279721461000},"page":"360-369","source":"Crossref","is-referenced-by-count":22,"title":["Photosensitizing activity of hypericin and hypericin acetate after topical application on normal mouse skin"],"prefix":"10.1093","volume":"158","author":[{"given":"A.","family":"Boiy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Roelandts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Van Den Oord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.M.","family":"De Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,11,28]]},"reference":[{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2165\/00002018-200225050-00004","article-title":"Drug-induced cutaneous photosensitivity","volume":"25","author":"Moore","year":"2002","journal-title":"Drug Saf"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB2|cit2","first-page":"573","article-title":"Wat is nieuw op het gebied van fotosensibilisatie?","volume":"53","author":"Roelandts","year":"1997","journal-title":"Tijdschr voor Geneesk"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1751-1097.1992.tb04222.x","article-title":"How does photodynamic therapy work?","volume":"55","author":"Henderson","year":"1992","journal-title":"Photochem Photobiol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2165\/00002512-199915010-00005","article-title":"Photodynamic therapy: a review","volume":"15","author":"McCaughan","year":"1999","journal-title":"Drugs Aging"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrc1071","article-title":"Photodynamic therapy for cancer","volume":"3","author":"Dolmans","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-2230.1999.00439.x","article-title":"The role of photodynamic therapy in dermatology","volume":"24","author":"Kurwa","year":"1999","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1046\/j.1365-2133.2002.04719.x","article-title":"Guidelines for topical photodynamic therapy: report of a workshop of the British Photodermatology Group","volume":"146","author":"Morton","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1080\/095466302317414645","article-title":"The advantages of aminolevulinic acid photodynamic therapy in dermatology","volume":"13","author":"Taylor","year":"2002","journal-title":"J Dermatol Treat"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1751-1097.1995.tb09154.x","article-title":"Distribution of 5-aminolevulinic acid-induced porphyrins in noduloulcerative basal cell carcinoma","volume":"62","author":"Peng","year":"1995","journal-title":"Photochem Photobiol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-1-4684-3641-9_6","article-title":"Hypericism","volume":"5","author":"Giese","year":"1980","journal-title":"Photochem Photobiol Rev"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"510","DOI":"10.7326\/0003-4819-130-6-199903160-00015","article-title":"Phase I studies of hypericin, the active compound in St John\u2019s wort, as an antiretroviral agent in HIV-infected adults","volume":"130","author":"Gulick","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1128\/AAC.45.2.517-524.2001","article-title":"Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St John\u2019s wort plant, in patients with chronic hepatitis C virus infection","volume":"45","author":"Jacobson","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pdpdt.2007.02.002","article-title":"Effect of vehicles and esterification on the penetration and distribution of hypericin in the skin of hairless mice","volume":"4","author":"Boiy","year":"2007","journal-title":"Photodiagnosis Photodynamic Ther"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF00810594","article-title":"Convenient semisynthetic route to hypericin","volume":"124","author":"Falk","year":"1993","journal-title":"Monatsh Chem"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1751-1097.1993.tb09215.x","article-title":"Singlet oxygen generation by porphyrins and the kinetics of 9,10-dimethylanthracene photosensitization in liposomes","volume":"57","author":"Gross","year":"1993","journal-title":"Photochem Photobiol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1063\/1.555934","article-title":"Quantum yields for the photosensitized formation of the lowest electronically excited singlet state of molecular oxygen in solution","volume":"22","author":"Wilkinson","year":"1993","journal-title":"J Phys Chem Ref Data"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1211\/0022357001774264","article-title":"Investigation of the absorption of hypericin into the skin of hairless mice","volume":"52","author":"Kamuhabwa","year":"2000","journal-title":"J Pharm Pharmacol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB18|cit18","first-page":"737","article-title":"Photodynamic therapy with hypericin in a mouse P388 tumor model: vascular effects determine the efficacy","volume":"18","author":"Chen","year":"2001","journal-title":"Int J Oncol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/lsm.1900100514","article-title":"Cutaneous phototoxic occurrences in patients receiving Photofrin","volume":"10","author":"Dougherty","year":"1990","journal-title":"Lasers Surg Med"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/1011-1344(90)85083-9","article-title":"Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience","volume":"6","author":"Kennedy","year":"1990","journal-title":"J Photochem Photobiol B Biol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1562\/0031-8655(2002)076<0320:POHBTH>2.0.CO;2","article-title":"Photobleaching of hypericin bound to human serum albumin, cultured adenocarcinoma cells and nude mice skin","volume":"76","author":"Uzdensky","year":"2002","journal-title":"Photochem Photobiol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB22|cit22","first-page":"1619","article-title":"Antitumour activity of photosensitized hypericin on A431 cell xenografts","volume":"16","author":"Vandenbogaerde","year":"1996","journal-title":"Anticancer Res"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1562\/0031-8655(2001)074<0126:CPIBHI>2.0.CO;2","article-title":"Cellular photodestruction induced by hypericin in AY-27 rat bladder carcinoma cells","volume":"74","author":"Kamuhabwa","year":"2001","journal-title":"Photochem Photobiol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/ijc.1324","article-title":"Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model","volume":"93","author":"Chen","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1751-1097.1989.tb04121.x","article-title":"The time course of cutaneous porphyrin photosensitization in the murine ear","volume":"49","author":"Bellnier","year":"1989","journal-title":"Photochem Photobiol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1751-1097.1998.tb02516.x","article-title":"Skin necrosis due to photodynamic action of benzoporphyrin depends on circulating rather than tissue drug levels: implications for control of photodynamic therapy","volume":"68","author":"Lin","year":"1998","journal-title":"Photochem Photobiol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0278-6915(84)90133-9","article-title":"Quantitative assessment of phototoxicity in the skin of hairless mice","volume":"22","author":"Sambuco","year":"1984","journal-title":"Food Chem Toxicol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0278-6915(89)90113-0","article-title":"A predictive mouse ear-swelling model for investigating topical phototoxicity","volume":"27","author":"Gerberick","year":"1989","journal-title":"Food Chem Toxicol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/1523-1747.ep12275644","article-title":"Cutaneous porphyrin photosensitization: murine ear swelling as a marker of the acute response","volume":"86","author":"Hawkins","year":"1986","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4613-2165-1_12","article-title":"The biological effects of photodynamic therapy on normal skin in mice - I. A light microscopic study","volume":"193","author":"Zhou","year":"1985","journal-title":"Adv Exp Med Biol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB31|cit31","first-page":"891","article-title":"Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence","volume":"136","author":"Divaris","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S1011-1344(00)00034-8","article-title":"Skin photosensitizing properties of Zn(II)-2(3), 9(10), 16(17), 23(24)-tetrakis-(4-oxy-N-methylpiperidinyl) phthalocyanine topically administered to mice","volume":"55","author":"Kassab","year":"2000","journal-title":"J Photochem Photobiol B Biol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0190-9622(95)91271-1","article-title":"Cutaneous photosensitivity diseases induced by exogenous agents","volume":"33","author":"Gould","year":"1995","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1751-1097.1998.tb05228.x","article-title":"The effect of fluence rate on tumor and normal tissue responses to photodynamic therapy","volume":"67","author":"Sitnik","year":"1998","journal-title":"Photochem Photobiol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/1011-1344(92)85108-7","article-title":"Endogeneous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy","volume":"14","author":"Kennedy","year":"1992","journal-title":"J Photochem Photobiol B Biol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1751-1097.1997.tb01940.x","article-title":"Phthalocyanine photodynamic therapy: disparate effects of pharmacologic inhibitors on cutaneous photosensitivity and on tumor regression","volume":"65","author":"Anderson","year":"1997","journal-title":"Photochem Photobiol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB37|cit37","first-page":"218","article-title":"Preferential relative porphyrin enrichment in solar keratoses upon topical application of delta-aminolevulinic acid methylester","volume":"68","author":"Fritsch","year":"1998","journal-title":"Photochem Photobiol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1751-1097.1983.tb04433.x","article-title":"Dose-time dependency of tumor formation by chronic UV exposure","volume":"37","author":"De Gruijl","year":"1983","journal-title":"Photochem Photobiol"},{"key":"10.1111\/j.1365-2133.2007.08329.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/(SICI)1097-0215(19970703)72:1<110::AID-IJC16>3.0.CO;2-N","article-title":"Photobleaching during and re-appearance after photodynamic therapy of topical ALA-induced fluorescence in UVB treated mouse skin","volume":"72","author":"Van Der Veen","year":"1997","journal-title":"Int J Cancer"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2133.2007.08329.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1365-2133.2007.08329.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:23:36Z","timestamp":1676384616000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/158\/2\/360\/6641522"}},"subtitle":["Topical photoactivity of hypericin (acetate)"],"short-title":[],"issued":{"date-parts":[[2007,11,28]]},"references-count":39,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2133.2007.08329.x","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,28]]}}}