{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:21:10Z","timestamp":1790716870242,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2375,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1111\/j.1365-2133.2008.08835.x","type":"journal-article","created":{"date-parts":[[2008,9,15]],"date-time":"2008-09-15T10:44:59Z","timestamp":1221475499000},"page":"645-651","source":"Crossref","is-referenced-by-count":121,"title":["Cutaneous manifestations of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome"],"prefix":"10.1093","volume":"160","author":[{"given":"M.","family":"Halabi-Tawil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"Ruemmele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Fraitag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rieux-Laucat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Neven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Brousse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"De Prost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Goulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bodemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/83707","article-title":"X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy","volume":"27","author":"Wildin","year":"2001","journal-title":"Nat Genet"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/83713","article-title":"The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3","volume":"27","author":"Bennett","year":"2001","journal-title":"Nat Genet"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB3","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/jmg.39.8.537","article-title":"Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome","volume":"39","author":"Wildin","year":"2002","journal-title":"J Med Genet"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB4","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI200320274","article-title":"The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery","volume":"112","author":"Sakaguchi","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB5","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jaci.2005.08.047","article-title":"Role of regulatory T cells in human diseases","volume":"116","author":"Chatila","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB6","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.jaci.2004.07.014","article-title":"Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma","volume":"114","author":"Karagiannidis","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB7","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1053\/j.gastro.2007.02.044","article-title":"Severe food allergy as a variant of IPEX syndrome caused by a deletion in a non coding region of the FOXP3 gene","volume":"132","author":"Torgerson","year":"2007","journal-title":"Gastroenterology"},{"issue":"Suppl.","key":"10.1111\/j.1365-2133.2008.08835.x-BIB8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jaut.2005.04.008","article-title":"IPEX and FOXP3: clinical and research perspectives","volume":"25","author":"Wildin","year":"2005","journal-title":"J Autoimmun"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB9","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.0105-2896.2005.00231.x","article-title":"FOXP3 acts a rheostat of the immune response","volume":"203","author":"Ochs","year":"2005","journal-title":"Immunol Rev"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0022-3476(82)80573-8","article-title":"An X-linked syndrome of diarrhea, polyendocrinopathy and fatal infection in infancy","volume":"100","author":"Powell","year":"1982","journal-title":"J Pediatr"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB11","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1210\/jc.2003-031080","article-title":"Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndrome","volume":"88","author":"Owen","year":"2003","journal-title":"J Clin Edocrinol Metab"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/00001574-200411000-00014","article-title":"Autoimmune enteropathy: molecular concepts","volume":"20","author":"Ruemmele","year":"2004","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB13","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1056\/NEJM200106073442304","article-title":"Treatment of the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) by allogenic bone marrow transplantation","volume":"344","author":"Baud","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1182\/blood-2006-05-025072","article-title":"Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning","volume":"109","author":"Rao","year":"2007","journal-title":"Blood"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB15","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1001\/archderm.140.4.466","article-title":"Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome","volume":"140","author":"Nieves","year":"2004","journal-title":"Arch Dermatol"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB16","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.cgh.2005.12.014","article-title":"Mechanistic associations of a mild phenotype of immunodysregulation, polyendocrinopathy, enteropathy, X-linked syndrome","volume":"4","author":"De Benedetti","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB17","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0016-5085(99)70340-9","article-title":"Identification of an autoimmune enteropathy-related 75-kilodalton antigen","volume":"117","author":"Kobayachi","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB18","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jpeds.2005.04.017","article-title":"Successful use of the new immune-suppressor sirolimus in IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome)","volume":"147","author":"Bindl","year":"2005","journal-title":"J Pediatr"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jaad.2005.08.047","article-title":"Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) associated with pemphigoid nodularis: a case report and review of the literature","volume":"55","author":"McGinness","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB20","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.jaad.2006.01.008","article-title":"Norwegian scabies mimicking onychomycosis and scalp dermatitis in a child with IPEX syndrome","volume":"56","author":"McLucas","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB21","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/(SICI)1096-8628(20000228)90:5<390::AID-AJMG9>3.0.CO;2-M","article-title":"Manifestations and linkage analysis in X-linked autoimmunity-immunodeficiency syndrome","volume":"90","author":"Ferguson","year":"2000","journal-title":"Am J Med Genet"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB22","first-page":"447","article-title":"Regulatory T cells","volume":"60","author":"Marinic","year":"2006","journal-title":"Acta Med Croatica"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB23","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1172\/JCI23215","article-title":"IL10-producing and naturally occurring CD4+ Tregs: limiting collateral damage","volume":"114","author":"O\u2019Garra","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB24","doi-asserted-by":"crossref","first-page":"37672","DOI":"10.1074\/jbc.M104521200","article-title":"Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation","volume":"276","author":"Schubert","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB25","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1073\/pnas.0501675102","article-title":"Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells","volume":"102","author":"Bettelli","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB26","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.4049\/jimmunol.177.5.3133","article-title":"Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor","volume":"177","author":"Lopes","year":"2006","journal-title":"J Immunol"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB27","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1073\/pnas.0509484103","article-title":"Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development","volume":"103","author":"Gavin","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB29","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/00002281-200307000-00010","article-title":"Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis","volume":"15","author":"Gambineri","year":"2003","journal-title":"Curr Opin Rheumatol"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB30","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jaci.2006.10.007","article-title":"CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes","volume":"119","author":"Caudy","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB31","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s002510100358","article-title":"A rare polyadenylation signal mutation of the FOXP3 gene (AAUAAA\u2192AAUGAA) leads to the IPEX syndrome","volume":"53","author":"Bennett","year":"2001","journal-title":"Immunogenetics"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB32","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nature05479","article-title":"Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression","volume":"445","author":"Wan","year":"2007","journal-title":"Nature"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB33","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jaci.2005.10.040","article-title":"Absence of T-regulatory cell expression and function in atopic dermatitis skin","volume":"117","author":"Verhagen","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB34","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jaci.2004.01.772","article-title":"T regulatory cells in atopic dermatitis and subversion of their activity by superantigens","volume":"113","author":"Ou","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/j.1365-2133.2008.08835.x-BIB35","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4049\/jimmunol.174.1.164","article-title":"Dysfunctional blood and target tissue CD4+ CD25 high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation","volume":"174","author":"Sugiyama","year":"2005","journal-title":"J Immunol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2133.2008.08835.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1365-2133.2008.08835.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T13:42:41Z","timestamp":1676382161000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/160\/3\/645\/6641494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2133.2008.08835.x","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}