{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:47:01Z","timestamp":1770504421442,"version":"3.49.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2253,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1111\/j.1365-2133.2009.09243.x","type":"journal-article","created":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T08:52:40Z","timestamp":1240217560000},"page":"19-24","source":"Crossref","is-referenced-by-count":43,"title":["Gene therapy of inherited skin adhesion disorders: a critical overview"],"prefix":"10.1093","volume":"161","author":[{"given":"M.","family":"De Luca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Mavilio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0959-437X(96)80005-0","article-title":"The genetics of human skin diseases","volume":"6","author":"Epstein","year":"1996","journal-title":"Curr Opin Genet Dev"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/1523-1747.ep12340471","article-title":"Laminins: a family of diverse multifunctional molecules of basement membranes","volume":"106","author":"Aumailley","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clindermatol.2004.09.015","article-title":"Progress in epidermolysis bullosa: from eponyms to molecular genetic classification","volume":"23","author":"Uitto","year":"2005","journal-title":"Clin Dermatol"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.ceb.2003.10.011","article-title":"The multifaceted adult epidermal stem cell","volume":"15","author":"Gambardella","year":"2003","journal-title":"Curr Opin Cell Biol"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.cell.2007.01.014","article-title":"Epithelial stem cells: turning over new leaves","volume":"128","author":"Blanpain","year":"2007","journal-title":"Cell"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0092-8674(01)00208-2","article-title":"Morphogenesis and renewal of hair follicles from adult multipotent stem cells","volume":"104","author":"Oshima","year":"2001","journal-title":"Cell"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB7","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2004.08.012","article-title":"Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche","volume":"118","author":"Blanpain","year":"2004","journal-title":"Cell"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB8","doi-asserted-by":"crossref","first-page":"14677","DOI":"10.1073\/pnas.0507250102","article-title":"Long-term renewal of hair follicles from clonogenic multipotent stem cells","volume":"102","author":"Claudinot","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB9","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1073\/pnas.84.8.2302","article-title":"Three clonal types of keratinocyte with different capacities for multiplication","volume":"84","author":"Barrandon","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB10","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/0092-8674(94)90383-2","article-title":"Location of stem cells of human hair follicles by clonal analysis","volume":"76","author":"Rochat","year":"1994","journal-title":"Cell"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2217\/17460751.1.1.45","article-title":"Regeneration of squamous epithelia from stem cells of cultured grafts","volume":"1","author":"De Luca","year":"2006","journal-title":"Regen Med"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB12","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1083\/jcb.145.4.769","article-title":"Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface","volume":"145","author":"Pellegrini","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB13","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1083\/jcb.200703003","article-title":"C\/EBPdelta regulates cell cycle and self-renewal of human limbal stem cells","volume":"177","author":"Barbaro","year":"2007","journal-title":"J Cell Biol"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB14","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1083\/jcb.149.5.1117","article-title":"Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes","volume":"149","author":"Dellambra","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB15","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM198408163110706","article-title":"Permanent coverage of large burn wounds with autologous cultured human epithelium","volume":"311","author":"Gallico","year":"1984","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1056\/NEJM199008233230806","article-title":"Treatment of posterior hypospadias by the autologous graft of cultured urethral epithelium","volume":"323","author":"Romagnoli","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB17","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/S0140-6736(96)11188-0","article-title":"Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium","volume":"349","author":"Pellegrini","year":"1997","journal-title":"Lancet"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB18","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1097\/00007890-199909270-00021","article-title":"The control of epidermal stem cells (holoclones) in the treatment of massive full-thickness burns with autologous keratinocytes cultured on fibrin","volume":"68","author":"Pellegrini","year":"1999","journal-title":"Transplantation"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB19","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1097\/00007890-200012150-00009","article-title":"Long-term regeneration of human epidermis on third degree burns transplanted with autologous cultured epithelium grown on a fibrin matrix","volume":"70","author":"Ronfard","year":"2000","journal-title":"Transplantation"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB20","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1097\/00007890-200111150-00002","article-title":"Autologous fibrin-cultured limbal stem cells permanently restore the corneal surface of patients with total limbal stem cell deficiency","volume":"72","author":"Rama","year":"2001","journal-title":"Transplantation"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/path.2441","article-title":"Epithelial stem cells in corneal regeneration and epidermal gene therapy","volume":"217","author":"Pellegrini","year":"2009","journal-title":"J Pathol"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB22","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1126\/science.3629250","article-title":"Expression of an exogenous growth hormone gene by transplantable human epidermal cells","volume":"237","author":"Morgan","year":"1987","journal-title":"Science"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB23","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1182\/blood.V95.9.2799.009k23_2799_2805","article-title":"Correction of the coagulation defect in hemophilia A mice through factor VIII expression in skin","volume":"95","author":"Fakharzadeh","year":"2000","journal-title":"Blood"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB24","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/1523-1747.ep12489019","article-title":"Retrovirus-mediated transduction of cultured epidermal keratinocytes","volume":"97","author":"Garlick","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB25","doi-asserted-by":"crossref","first-page":"10371","DOI":"10.1073\/pnas.93.19.10371","article-title":"Clonal analysis of stably transduced human epidermal stem cells in culture","volume":"93","author":"Mathor","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB26","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1089\/hum.1998.9.8-1187","article-title":"Long-term expression of human clotting factor IX from retrovirally transduced primary human keratinocytes in vivo","volume":"9","author":"White","year":"1998","journal-title":"Hum Gene Ther"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB27","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/1523-1747.ep12344976","article-title":"Loss of expression of a retrovirus-transduced gene in human keratinocytes","volume":"106","author":"Fenjves","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB28","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng0293-180","article-title":"Towards gene therapy for haemophilia B using primary human keratinocytes","volume":"3","author":"Gerrard","year":"1993","journal-title":"Nat Genet"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB29","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1073\/pnas.95.8.4356","article-title":"Evidence for keratinocyte stem cells in vitro: long term engraftment and persistence of transgene expression from retrovirus-transduced keratinocytes","volume":"95","author":"Kolodka","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB30","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/sj.gt.3300689","article-title":"Optimised retroviral infection of human epidermal keratinocytes: long-term expression of transduced integrin gene following grafting on to SCID mice","volume":"5","author":"Levy","year":"1998","journal-title":"Gene Ther"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB31","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/ng1041","article-title":"Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa","volume":"32","author":"Chen","year":"2002","journal-title":"Nat Genet"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB32","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1089\/hum.1998.9.9-1359","article-title":"Corrective transduction of human epidermal stem cells in laminin-5-dependent junctional epidermolysis bullosa","volume":"9","author":"Dellambra","year":"1998","journal-title":"Hum Gene Ther"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB33","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1073\/pnas.091484998","article-title":"In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa","volume":"98","author":"Robbins","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB34","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/nm1504","article-title":"Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells","volume":"12","author":"Mavilio","year":"2006","journal-title":"Nat Med"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1126\/science.1088547","article-title":"LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1","volume":"302","author":"Hacein-Bey-Abina","year":"2003","journal-title":"Science"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB36","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJMra032207","article-title":"Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency","volume":"350","author":"McCormack","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB37","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1172\/JCI35700","article-title":"Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1","volume":"118","author":"Hacein-Bey-Abina","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB38","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1172\/JCI35798","article-title":"Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients","volume":"118","author":"Howe","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB39","volume-title":"Retroviruses","author":"Coffin","year":"1997"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB40","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nrmicro1263","article-title":"Genome-wide analysis of retroviral DNA integration","volume":"3","author":"Bushman","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB41","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1182\/blood-2007-01-068759","article-title":"Hot spots of retroviral integration in human CD34+ hematopoietic cells","volume":"110","author":"Cattoglio","year":"2007","journal-title":"Blood"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB42","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1073\/pnas.0507496103","article-title":"Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells","volume":"103","author":"Recchia","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB43","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1172\/JCI31666","article-title":"Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy","volume":"117","author":"Aiuti","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB44","doi-asserted-by":"crossref","first-page":"9873","DOI":"10.1128\/JVI.72.12.9873-9880.1998","article-title":"Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery","volume":"72","author":"Zufferey","year":"1998","journal-title":"J Virol"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB45","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nbt1216","article-title":"Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration","volume":"24","author":"Montini","year":"2006","journal-title":"Nat Biotechnol"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB46","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1038\/mt.2008.204","article-title":"Correction of laminin-5 deficiency in human epidermal stem cells by transcriptionally targeted lentiviral vectors","volume":"16","author":"Di Nunzio","year":"2008","journal-title":"Mol Ther"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB47","doi-asserted-by":"crossref","first-page":"24429","DOI":"10.1074\/jbc.M003440200","article-title":"Development and characterization of a recombinant truncated type VII collagen \u2018minigene\u2019. Implication for gene therapy of dystrophic epidermolysis bullosa","volume":"275","author":"Chen","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB48","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.1371\/journal.pgen.0020133","article-title":"A look to future directions in gene therapy research for monogenic diseases","volume":"2","author":"Porteus","year":"2006","journal-title":"PLoS Genet"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB49","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/nm766","article-title":"Stable nonviral genetic correction of inherited human skin disease","volume":"8","author":"Ortiz-Urda","year":"2002","journal-title":"Nat Med"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB50","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ymthe.2005.08.003","article-title":"Mammalian gene targeting with designed zinc finger nucleases","volume":"13","author":"Porteus","year":"2006","journal-title":"Mol Ther"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB51","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1038\/jid.2008.78","article-title":"Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa","volume":"128","author":"Wong","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB52","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1182\/blood-2008-06-161299","article-title":"Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cells","volume":"113","author":"Tolar","year":"2009","journal-title":"Blood"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB53","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/nm0997-970","article-title":"The fate of individual myoblasts after transplantation into muscles of DMD patients","volume":"3","author":"Gussoni","year":"1997","journal-title":"Nat Med"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB54","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.279.5356.1528","article-title":"Muscle regeneration by bone marrow-derived myogenic progenitors","volume":"279","author":"Ferrari","year":"1998","journal-title":"Science"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB55","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/43919","article-title":"Dystrophin expression in the mdx mouse restored by stem cell transplantation","volume":"401","author":"Gussoni","year":"1999","journal-title":"Nature"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB56","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/35082631","article-title":"Failure to correct murine muscular dystrophy","volume":"411","author":"Ferrari","year":"2001","journal-title":"Nature"},{"key":"10.1111\/j.1365-2133.2009.09243.x-BIB57","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1172\/JCI0216098","article-title":"Long-term persistence of donor nuclei in a Duchenne muscular dystrophy patient receiving bone marrow transplantation","volume":"110","author":"Gussoni","year":"2002","journal-title":"J Clin Invest"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2133.2009.09243.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1365-2133.2009.09243.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T13:45:35Z","timestamp":1676382335000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/161\/1\/19\/6642048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2133.2009.09243.x","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}