{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:08:30Z","timestamp":1772222910064,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2191,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1111\/j.1365-2133.2009.09256.x","type":"journal-article","created":{"date-parts":[[2009,5,27]],"date-time":"2009-05-27T08:00:17Z","timestamp":1243411217000},"page":"560-567","source":"Crossref","is-referenced-by-count":21,"title":["Hydroxyisohexyl 3-cyclohexene carboxaldehyde allergy: relationship between patch test and repeated open application test thresholds"],"prefix":"10.1093","volume":"161","author":[{"given":"L.A.","family":"Fischer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Menn\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Avnstorp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.B.","family":"Kasting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.D.","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1034\/j.1600-0536.2002.460509.x","article-title":"Lyral has been included in the patch test standard series in Germany","volume":"46","author":"Geier","year":"2002","journal-title":"Contact Dermatitis"},{"issue":"Suppl.","key":"10.1111\/j.1365-2133.2009.09256.x-BIB2","first-page":"1S","article-title":"Monographs on fragrance raw materials","volume":"30","author":"Ford","year":"1992","journal-title":"Food Chem Toxicol"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB3","first-page":"65","article-title":"Safety evaluation of perfumed shampoos: dose\/response relationships for product use testing by presensitized subjects","volume":"3","author":"Benke","year":"1984","journal-title":"J Toxicol"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-0536.1987.tb02640.x","article-title":"Contact allergy to cosmetics: causative ingredients","volume":"17","author":"de Groot","year":"1987","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB5","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1600-0536.1994.tb02020.x","article-title":"Allergic contact dermatitis from the synthetic fragrances Lyral and acetyl cedrene in separate underarm deodorant preparations","volume":"31","author":"Handley","year":"1994","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1034\/j.1600-0536.2003.480212_4.x","article-title":"Hydroxymethyl pentylcyclohexene-carboxaldehyde (Lyral) as a fragrance allergen in the UK","volume":"48","author":"Baxter","year":"2003","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1600-0536.2008.01397.x","article-title":"Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral) is still a frequent allergen","volume":"59","author":"Braendstrup","year":"2008","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB8","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1046\/j.1365-2133.1999.03208.x","article-title":"Lyral is an important sensitizer in patients sensitive to fragrances","volume":"141","author":"Frosch","year":"1999","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-0536.2007.01292.x","article-title":"Recommendation to include fragrance mix 2 and hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral) in the European baseline patch test series","volume":"58","author":"Bruze","year":"2008","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1034\/j.1600-0536.2002.470406.x","article-title":"Structure - activity relationships for selected fragrance allergens","volume":"47","author":"Patlewicz","year":"2002","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.0105-1873.2004.00442.x","article-title":"Compliance in contact allergy with focus on cosmetic labelling: a qualitative research project","volume":"51","author":"Noiesen","year":"2004","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1600-0536.2007.01170.x","article-title":"Difficulties in avoiding exposure to allergens in cosmetics","volume":"57","author":"Noiesen","year":"2007","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB13","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1034\/j.1600-0536.2003.00126.x","article-title":"Hydroxyisohexyl 3-cyclohexene carboxaldehyde known as Lyral: quantitative aspects and risk assessment of an important fragrance allergen","volume":"48","author":"Johansen","year":"2003","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB14","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1600-0536.2007.01028.x","article-title":"Experimental elicitation with hydroxyisohexyl-3-cyclohexene carboxaldehyde-containing deodorants","volume":"56","author":"Jorgensen","year":"2007","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB15","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.0105-1873.2003.0214.x","article-title":"Chloroatranol, an extremely potent allergen hidden in perfumes: a dose-response elicitation study","volume":"49","author":"Johansen","year":"2003","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB16","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1600-0536.1991.tb01758.x","article-title":"Relationship between use test and threshold patch test concentration in patients sensitive to 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one (MCI\/MI)","volume":"24","author":"Menne","year":"1991","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/taap.2000.9095","article-title":"The time-dose-response relationship for elicitation of contact dermatitis in isoeugenol allergic individuals","volume":"170","author":"Andersen","year":"2001","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB18","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/000155598433476","article-title":"Repeated open application tests (ROAT) in patients allergic to colophony - evaluated visually and with bioengineering techniques","volume":"78","author":"Farm","year":"1998","journal-title":"Acta Derm Venereol"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1034\/j.1600-0536.2003.00094.x","article-title":"Deodorants: an experimental provocation study with hydroxycitronellal","volume":"48","author":"Svedman","year":"2003","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1600-0536.1996.tb02167.x","article-title":"Threshold responses in cinnamic-aldehyde-sensitive subjects: results and methodological aspects","volume":"34","author":"Johansen","year":"1996","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.0105-1873.2005.00529.x","article-title":"Quantitative patch and repeated open application testing in methyldibromo glutaronitrile-sensitive patients","volume":"52","author":"Schnuch","year":"2005","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB22","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/3-540-31301-X_32","volume-title":"Contact Dermatitis","author":"Liden","year":"2006"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB23","unstructured":"23European Parliament and Council Directive 94\/27\/EC of 30 June 1994 amending for the 12th time Directive 76\/769\/EEC on the approximation of the laws, regulations and administrative provisions of the Member States relating to restrictions on the marketing and use of certain dangerous substances and preparations; 1994."},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB24","unstructured":"24Commission Directive 2004\/96\/EC of 27 September 2004 amending Council Directive 76\/769\/EEC as regards restrictions on the marketing and use of nickel for piercing post assemblies for the purpose of adapting its Annex I to technical progress; 2004."},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB25","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1046\/j.1365-2133.2002.04666.x","article-title":"Decrease in nickel sensitization in a Danish schoolgirl population with ears pierced after implementation of a nickel-exposure regulation","volume":"146","author":"Jensen","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB26","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1046\/j.1365-2133.2000.03362.x","article-title":"Changes in the pattern of sensitization to common contact allergens in Denmark between 1985-86 and 1997-98, with a special view to the effect of preventive strategies","volume":"142","author":"Johansen","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB27","volume-title":"Opinion Concerning Methyldibromo Glutaronitrile","author":"Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB28","volume-title":"Opinion on Methyldibromo Glutaronitrile","author":"Scientific Committee on Consumer Products"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1600-0536.2008.01364.x","article-title":"Decreasing trends in methyldibromo glutaronitrile contact allergy - following regulatory intervention","volume":"59","author":"Johansen","year":"2008","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB30","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1365-2133.2007.08095.x","article-title":"Nickel allergy: relationship between patch test and repeated open application test thresholds","volume":"157","author":"Fischer","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB31","first-page":"1138","article-title":"Methyldibromo glutaronitrile allergy: relationship between patch test and repeated open application test thresholds","volume":"159","author":"Fischer","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1600-0536.1986.tb01229.x","article-title":"The repeated open application test (ROAT)","volume":"14","author":"Hannuksela","year":"1986","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1467-2494.2001.00079.x","article-title":"A physico-chemical properties based model for estimating evaporation and absorption rates of perfumes from skin","volume":"23","author":"Kasting","year":"2001","journal-title":"Int J Cosmet Sci"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB34","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/3-540-31301-X_22","volume-title":"Contact Dermatitis","author":"Wahlberg","year":"2006"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/000155598443088","article-title":"The significance of previous contact dermatitis for elicitation of contact allergy to nickel","volume":"78","author":"Hinds\u00e9n","year":"1998","journal-title":"Acta Derm Venereol"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1600-0536.1998.tb05850.x","article-title":"The repeated open application test: suggestions for a scale of evaluation","volume":"39","author":"Johansen","year":"1998","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB37","volume-title":"Handbook of Chemical Property Estimation Methods: Environmental Behavior of Organic Compounds","author":"Lyman","year":"1990"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB38","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/1520-6017(200102)90:2<234::AID-JPS14>3.0.CO;2-V","article-title":"Estimation of the aqueous solubility. I. Application to organic nonelectrolytes","volume":"90","author":"Jain","year":"2001","journal-title":"J Pharm Sci"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB39","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1600-0536.1998.tb05887.x","article-title":"Deodorants: a clinical provocation study in fragrance-sensitive individuals","volume":"39","author":"Johansen","year":"1998","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB40","first-page":"257","article-title":"Patch test methods. II. Regional variations of patch test responses","volume":"45","author":"Magnusson","year":"1965","journal-title":"Acta Derm Venereol"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB41","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1034\/j.1600-0536.2002.470207.x","article-title":"Dose-time relationships for elicitation of contact allergy to para-phenylenediamine","volume":"47","author":"Hextall","year":"2002","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-0536.1998.tb05837.x","article-title":"The effect of patch duration on the elicitation of para-phenylenediamine contact allergy","volume":"39","author":"McFadden","year":"1998","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.0105-1873.2005.00523.x","article-title":"Experimental nickel elicitation thresholds - a review focusing on occluded nickel exposure","volume":"52","author":"Fischer","year":"2005","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB44","first-page":"709","article-title":"Quantitative relationships between sensitizing dose of DNCB and reactivity in normal subjects","volume":"53","author":"Friedmann","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB45","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.0105-1873.2005.00481.x","article-title":"Repeated open application test with methyldibromo glutaronitrile, a multicentre study within the EECDRG","volume":"52","author":"Gruvberger","year":"2005","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB46","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1600-0536.2006.00906.x","article-title":"The impact of exposure variables on the induction of skin sensitization","volume":"55","author":"Basketter","year":"2006","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB47","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1600-0536.2007.01072.x","article-title":"Intermittent exposure to low-concentration paraphenylenediamine can be equivalent to single, higher-dose exposure","volume":"56","author":"White","year":"2007","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB48","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.0105-1873.2005.00505.x","article-title":"Methyldibromo glutaronitrile contact allergy: effect of single versus repeated daily exposure","volume":"52","author":"Jensen","year":"2005","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB49","unstructured":"49 Bhatia SP , Lalko J , Brain KR et\u00a0al. In-vitro human skin penetration of the fragrance material HMPCC. Society of Toxicology 46th Annual Meeting and ToxExpo, Charlotte, NC, U.S.A., 25-29 March 2007."},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB50","unstructured":"50 Mowitz M , Zimerson E , Svedman C , Bruze M . Stability of fragrance test preparations applied in test chambers. Presented at the 9th Congress of the European Society of Contact Dermatitis, Estoril, Portugal, 28-31 May 2008."},{"key":"10.1111\/j.1365-2133.2009.09256.x-BIB51","first-page":"80","article-title":"Identification of risk products for fragrance contact allergy: a case-referent study based on patients\u2019 histories","volume":"9","author":"Johansen","year":"1998","journal-title":"Am J Contact Dermat"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2133.2009.09256.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1365-2133.2009.09256.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T13:45:40Z","timestamp":1676382340000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/161\/3\/560\/6642047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2133.2009.09256.x","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}