{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:28:53Z","timestamp":1791250133752,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Background Recently, photodynamic therapy (PDT) using a variety of light sources and photosensitizers has been used for the treatment of acne vulgaris. PDT with aminolaevulinic or methylaminolaevulinic acid has also been used in clinical trials as a treatment for acne, but adverse effects such as pain, erythema and pustular eruption are common. Indocyanine green (ICG) and indole-3-acetic acid (IAA), newer photosensitizers, are known to have minimal adverse effects.<\/jats:p><jats:p>Objectives This study was designed to compare the safety and efficacy of PDT using ICG and PDT using IAA in the treatment of mild to moderate acne vulgaris.<\/jats:p><jats:p>Methods In this prospective, single-blind, clinical trial, 34 patients with mild to moderate acne were treated with IAA with green light (520 nm) on half of the face and with ICG with near-infrared radiation (805 nm) on the other half. The procedure was carried out five times at 1-week intervals.<\/jats:p><jats:p>Results With regard to acne lesions (inflammatory and noninflammatory) and sebum secretion, there were statistically significant reductions at each time point compared with the baseline values (P &amp;lt;0\u00b705). However, there were no statistically significant differences between the two treatment types (P &amp;gt;0\u00b705). Both ICG-PDT and IAA-PDT showed better responses for inflammatory lesions than for noninflammatory lesions (P &amp;lt;0\u00b705). Subjective satisfaction score were statistically significant at 4 and 5 weeks of treatment as well as at 1, 2 and 3 months follow-up (P &amp;lt;0\u00b705).<\/jats:p><jats:p>Conclusions Both PDT with ICG and PDT with IAA are safe and effective for the treatment of mild to moderate acne vulgaris.<\/jats:p>","DOI":"10.1111\/j.1365-2133.2011.10472.x","type":"journal-article","created":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T12:35:28Z","timestamp":1308659728000},"page":"1095-1100","source":"Crossref","is-referenced-by-count":50,"title":["A comparative split-face study of photodynamic therapy with indocyanine green and indole-3-acetic acid for the treatment of acne vulgaris"],"prefix":"10.1093","volume":"165","author":[{"given":"M.S.","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Kosin University College of Medicine, 34 Amnam-Dong, Seo-gu, Busan 602-702, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.S.","family":"Doh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kosin University College of Medicine, 34 Amnam-Dong, Seo-gu, Busan 602-702, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.S.","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kosin University College of Medicine, 34 Amnam-Dong, Seo-gu, Busan 602-702, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.S.","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kosin University College of Medicine, 34 Amnam-Dong, Seo-gu, Busan 602-702, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.S.","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kosin University College of Medicine, 34 Amnam-Dong, Seo-gu, Busan 602-702, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.T.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kosin University College of Medicine, 34 Amnam-Dong, Seo-gu, Busan 602-702, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,11,1]]},"reference":[{"key":"2023012703563605200_b1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1365-2230.2009.03683.x","article-title":"Management of acne vulgaris: an evidence-based update","volume":"35","author":"Ingram","year":"2010","journal-title":"Clin Exp Dermatol"},{"key":"2023012703563605200_b2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1529-8019.2008.00175.x","article-title":"New and emerging treatments in dermatology: acne","volume":"21","author":"Katsambas","year":"2008","journal-title":"Dermatol Ther"},{"key":"2023012703563605200_b3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.clindermatol.2004.03.014","article-title":"Acne: systemic treatment","volume":"22","author":"Katsambas","year":"2004","journal-title":"Clin Dermatol"},{"key":"2023012703563605200_b4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.sder.2008.06.001","article-title":"Topical retinoids in the treatment of acne vulgaris","volume":"27","author":"Zaenglein","year":"2008","journal-title":"Semin Cutan Med Surg"},{"key":"2023012703563605200_b5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.clindermatol.2009.03.005","article-title":"The role of isotretinoin in acne therapy: why not as first-line therapy? 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