{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:46:28Z","timestamp":1776271588656,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Background Primary eccrine porocarcinoma is a rare cutaneous neoplasm and there is no consensus concerning its surgical management.<\/jats:p>\n               <jats:p>Objectives To conduct a retrospective analysis of all the cases of eccrine porocarcinoma seen in our hospital in order to identify prognostic factors.<\/jats:p>\n               <jats:p>Methods Clinical data were retrieved from the patients\u2019 files. Each histological sample was reviewed by the pathologist and classified into three eccrine porocarcinoma subtypes: \u2018infiltrative\u2019, \u2018pushing\u2019 and \u2018pagetoid\u2019 eccrine porocarcinoma, according to Robson\u2019s criteria. Statistical methods were used to estimate the recurrence risk.<\/jats:p>\n               <jats:p>Results Twenty-four patients were included. The surgical margins realized were \u2265 2 cm or &amp;lt; 2 cm in six and 13 patients, respectively, and slow Mohs procedure was performed in two patients. Ten, seven and two patients presented with \u2018infiltrative\u2019, \u2018pushing\u2019 or \u2018pagetoid\u2019 eccrine porocarcinoma, respectively. Eight patients (of 23) experienced recurrences (35%). The recurrence risk was linked to the histological subtype: two out of two pagetoid eccrine porocarcinoma, four out of 10 \u2018infiltrative\u2019 and none of seven \u2018pushing\u2019 eccrine porocarcinoma recurred (P =0\u00b7026). The recurrence risk was not associated with epidermal growth factor receptor status, nor the margin realized.<\/jats:p>\n               <jats:p>Conclusions The recurrence risk of \u2018pushing\u2019 eccrine porocarcinoma is significantly lower than for \u2018infiltrative\u2019 eccrine porocarcinoma. Based on these considerations, a decisional algorithm might be proposed: first step, excisional biopsy of the primary eccrine porocarcinoma and identification of the histological subtype; second step, infiltrative or pagetoid porocarcinoma should be excised with an additional modified micrographic Mohs procedure, while no additional surgery is needed for \u2018pushing\u2019 eccrine porocarcinoma if the first excisional biopsy is complete. Although demonstrated in a limited case series, the histological subtype might guide the surgical management of primary eccrine porocarcinoma.<\/jats:p>","DOI":"10.1111\/j.1365-2133.2011.10486.x","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T13:45:13Z","timestamp":1309441513000},"page":"985-989","source":"Crossref","is-referenced-by-count":67,"title":["Factors in the surgical management of primary eccrine porocarcinoma: prognostic histological factors can guide the surgical procedure"],"prefix":"10.1093","volume":"165","author":[{"given":"E.","family":"Belin","sequence":"first","affiliation":[{"name":"Skin Cancer Unit, Department of Dermatology, Saint Andr\u00e9\u2019s Hospital, 1 Rue Jean Burguet 33075 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ezzedine","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit, Department of Dermatology, Saint Andr\u00e9\u2019s Hospital, 1 Rue Jean Burguet 33075 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Stanislas","sequence":"additional","affiliation":[{"name":"Departments of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Lalanne","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit, Department of Dermatology, Saint Andr\u00e9\u2019s Hospital, 1 Rue Jean Burguet 33075 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Beylot-Barry","sequence":"additional","affiliation":[{"name":"Dermatology, Haut Leveque\u2019s Hospital, Bordeaux Pessac, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Taieb","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit, Department of Dermatology, Saint Andr\u00e9\u2019s Hospital, 1 Rue Jean Burguet 33075 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Vergier","sequence":"additional","affiliation":[{"name":"Departments of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Jouary","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit, Department of Dermatology, Saint Andr\u00e9\u2019s Hospital, 1 Rue Jean Burguet 33075 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,11,1]]},"reference":[{"key":"2023012703563485300_b1","first-page":"1574","article-title":"Mohs surgery for malignant eccrine neoplasms","volume":"30","author":"Wildemore","year":"2004","journal-title":"Dermatol Surg"},{"key":"2023012703563485300_b2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archderm.1963.01590230105015","article-title":"Epidermotropic eccrine carcinoma. A case combining features of eccrine poroma and Paget\u2019s dermatosis","volume":"88","author":"Pinkus","year":"1963","journal-title":"Arch Dermatol"},{"key":"2023012703563485300_b3","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000253989","article-title":"Oncogenic differentiation of the intraepidermal eccrine sweat duct: eccrine poroma, poroepithelioma and porocarcinoma","volume":"138","author":"Mishima","year":"1969","journal-title":"Dermatologica"},{"key":"2023012703563485300_b4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1001\/archderm.1983.01650260012008","article-title":"Eccrine adenocarcinoma. A clinicopathologic study of 35 cases","volume":"119","author":"Mehregan","year":"1983","journal-title":"Arch Dermatol"},{"key":"2023012703563485300_b5","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1097\/00000478-200106000-00002","article-title":"Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases","volume":"25","author":"Robson","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"2023012703563485300_b6","first-page":"680","article-title":"Agence Nationale d\u2019Accr\u00e9ditation et d\u2019Evaluation (ANAES). [Recommendations for basal cell carcinoma]","volume":"131(6\u20137 Pt2)","author":"Coulomb","year":"2004","journal-title":"Ann Dermatol Venereol"},{"key":"2023012703563485300_b7","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.ctrv.2008.06.002","article-title":"Dermatofibrosarcoma protuberans: wide local excision vs. Mohs micrographic surgery","volume":"34","author":"Paradisi","year":"2008","journal-title":"Cancer Treat Rev"},{"key":"2023012703563485300_b8","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jaad.2007.02.011","article-title":"Staged excision versus Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma","volume":"57","author":"Walling","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"2023012703563485300_b9","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1046\/j.1524-4725.1999.99121.x","article-title":"Eccrine porocarcinoma treated with Mohs micrographic surgery: a report of five cases","volume":"25","author":"Wittenberg","year":"1999","journal-title":"Dermatol Surg"},{"key":"2023012703563485300_b10","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0190-9622(92)70187-K","article-title":"Eccrine porocarcinoma of the face","volume":"27","author":"Snow","year":"1992","journal-title":"J Am Acad Dermatol"},{"key":"2023012703563485300_b11","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1046\/j.1524-4725.1999.99041.x","article-title":"Malignant eccrine poroma in an elderly African-American woman","volume":"25","author":"McMichael","year":"1999","journal-title":"Dermatol Surg"},{"key":"2023012703563485300_b12","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1046\/j.1365-4362.2003.01779.x","article-title":"Eccrine porocarcinoma arising in a seborrheic keratosis evaluated with dermoscopy and treated with Mohs\u2019 technique","volume":"42","author":"Johr","year":"2003","journal-title":"Int J Dermatol"},{"key":"2023012703563485300_b13","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1365-4632.2006.02735.x","article-title":"Eccrine porocarcinoma arising in two African American patients: distinct presentations both treated with Mohs micrographic surgery","volume":"45","author":"Cowden","year":"2006","journal-title":"Int J Dermatol"},{"key":"2023012703563485300_b14","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1097\/00042728-200404000-00026","article-title":"Eccrine porocarcinoma of the eyelid treated with Mohs micrographic surgery","volume":"30","author":"D\u2019Ambrosia","year":"2004","journal-title":"Dermatol Surg"},{"key":"2023012703563485300_b15","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-2133.2005.07068.x","article-title":"Conventional histology vs. three-dimensional histology in lentigo maligna melanoma","volume":"154","author":"Moehrle","year":"2006","journal-title":"Br J Dermatol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2133.2011.10486.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/165\/5\/985\/47504212\/bjd0985.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/165\/5\/985\/47504212\/bjd0985.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T04:25:27Z","timestamp":1674793527000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/165\/5\/985\/6643949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,1]]},"references-count":15,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,11,1]]},"published-print":{"date-parts":[[2011,11,1]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2133.2011.10486.x","relation":{},"ISSN":["1365-2133","0007-0963"],"issn-type":[{"value":"1365-2133","type":"electronic"},{"value":"0007-0963","type":"print"}],"subject":[],"published-other":{"date-parts":[[2011,11,1]]},"published":{"date-parts":[[2011,11,1]]}}}