{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:19:52Z","timestamp":1774898392614,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1384,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1111\/j.1365-2133.2011.10597.x","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T12:44:37Z","timestamp":1315313077000},"page":"1236-1243","source":"Crossref","is-referenced-by-count":22,"title":["Demonstration of autoantibodies against tyrosine hydroxylase in patients with alopecia areata"],"prefix":"10.1093","volume":"165","author":[{"given":"E.H.","family":"Kemp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.K.","family":"Sandhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.P.","family":"Weetman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"McDonagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,11,17]]},"reference":[{"issue":"Suppl. 1","key":"10.1111\/j.1365-2133.2011.10597.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1046\/j.1365-4362.1999.00004.x","article-title":"Alopecia areata: diagnosis and management","volume":"38","author":"Shapiro","year":"1999","journal-title":"Int J Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/(SICI)1097-0029(19970815)38:4<443::AID-JEMT12>3.0.CO;2-J","article-title":"Morphological analysis of hair follicles in alopecia areata","volume":"38","author":"Tobin","year":"1997","journal-title":"Microsc Res Tech"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4065\/70.7.628","article-title":"Incidence of alopecia areata in Olmsted County, Minnesota 1975-1989","volume":"70","author":"Safavi","year":"1995","journal-title":"Mayo Clin Proc"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1046\/j.1365-2133.2001.04195.x","article-title":"Strategies of coping and quality of life in women with alopecia","volume":"144","author":"Schmidt","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.autrev.2005.07.001","article-title":"Alopecia areata: a tissue specific autoimmune disease of the hair follicle","volume":"5","author":"Gilhar","year":"2005","journal-title":"Autoimmun Rev"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1172\/JCI31942","article-title":"Lymphocytes, neuropeptides, and genes involved in alopecia areata","volume":"117","author":"Gilhar","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB7|cit7","first-page":"541","article-title":"Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb?","volume":"66","author":"Paus","year":"1994","journal-title":"Yale J Biol Med"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1038\/jid.2010.180","article-title":"Hair follicles from alopecia areata patients exhibit alterations in immune privilege-associated gene expression in advance of hair loss","volume":"130","author":"Kang","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0190-9622(84)70152-6","article-title":"T cell subpopulations in alopecia areata","volume":"11","author":"Todes-Taylor","year":"1984","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1001\/archderm.128.8.1072","article-title":"Alopecia areata: autoreactive T cells are variably enriched in scalp lesions relative to peripheral blood","volume":"128","author":"Kalish","year":"1992","journal-title":"Arch Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1001\/archderm.138.7.916","article-title":"Alopecia areata is mediated by co-operation between CD4+ and CD8+ T lymphocytes: transfer to human scalp explants on Prkdc (SCID) mice","volume":"138","author":"Gilhar","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1365-2133.1996.tb01149.x","article-title":"In vivo depletion of CD8+ T cells restores hair growth in the DEBR model for alopecia areata","volume":"135","author":"McElwee","year":"1996","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1046\/j.1365-2133.1999.02705.x","article-title":"Partial restoration of hair growth in the DEBR model for alopecia areata after in vivo depletion of CD4+ T cells","volume":"140","author":"McElwee","year":"1999","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1046\/j.0022-202x.2001.01583.x","article-title":"Melanocyte-associated T cell epitopes can function as autoantigens for transfer of alopecia areata to human scalp explants on Prkdc (SCID) mice","volume":"117","author":"Gilhar","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/1523-1747.ep12584237","article-title":"Lymphocyte-mediated alopecia in C57B1\/6 mice following successful immunotherapy for melanoma","volume":"107","author":"Becker","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00403-006-0668-y","article-title":"Induction of cellular immunity against hair follicle melanocyte causes alopecia","volume":"298","author":"Nagai","year":"2006","journal-title":"Arch Dermatol Res"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/archderm.133.1.57","article-title":"Hair follicle structures targeted by antibodies in patients with alopecia areata","volume":"133","author":"Tobin","year":"1997","journal-title":"Arch Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1046\/j.1087-0024.2003.00805.x","article-title":"Characterisation of hair follicle antigens targeted by the anti-hair follicle immune response","volume":"8","author":"Tobin","year":"2003","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB19|cit19","first-page":"327","article-title":"Diphencyprone immunotherapy alters anti-hair follicle antibody status in patients with alopecia areata","volume":"12","author":"Tobin","year":"2002","journal-title":"Eur J Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1365-2133.1992.tb07815.x","article-title":"Failure of passive transfer of serum from patients with alopecia areata and alopecia universalis to inhibit hair growth in transplants of human scalp skin grafted on to nude mice","volume":"126","author":"Gilhar","year":"1992","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB21|cit21","first-page":"237","volume-title":"Hair Research for the Next Millennium","author":"Tobin","year":"1996"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1021\/pr100422u","article-title":"Trichohyalin is a potential major autoantigen in human alopecia areata","volume":"9","author":"Leung","year":"2010","journal-title":"J Proteome Res"},{"issue":"Suppl. 5","key":"10.1111\/j.1365-2133.2011.10597.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1038\/jid.1995.44","article-title":"No cell-surface-reactive antibodies against cultured autologous melanocytes found in alopecia areata sera","volume":"104","author":"Koury","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0090-1229(88)90025-6","article-title":"Western blot analysis of serum antibody reactivity with human melanoma cell antigens in alopecia areata and vitiligo","volume":"48","author":"Galbraith","year":"1988","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0306-4522(93)90267-J","article-title":"Four isoforms of tyrosine hydroxylase are expressed in human brain","volume":"54","author":"Lewis","year":"1993","journal-title":"Neuroscience"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1006\/bbrc.1999.1945","article-title":"Identification of tyrosine hydroxylase as an autoantigen in autoimmune polyendocrine syndrome type 1","volume":"267","author":"Hedstrand","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-0625.2010.01181.x","article-title":"Autoantibodies against tyrosine hydroxylase in patients with non-segmental (generalised) vitiligo","volume":"20","author":"Kemp","year":"2011","journal-title":"Exp Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/1523-1747.ep12276556","article-title":"Detection of tyrosinase autoantibodies in the sera of vitiligo patients using 35S-labelled recombinant human tyrosinase in a radioimmunoassay","volume":"109","author":"Kemp","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1046\/j.1365-2249.1997.4781381.x","article-title":"Immunoprecipitation of melanogenic enzyme autoantigens with vitiligo sera: evidence for cross-reactive autoantibodies to tyrosinase and tyrosinase-related protein-2 (TRP-2)","volume":"109","author":"Kemp","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1046\/j.1365-2133.1998.02503.x","article-title":"Autoantibodies to tyrosinase-related protein-1 detected in the sera of vitiligo patients using a quantitative radiobinding assay","volume":"139","author":"Kemp","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1046\/j.1365-2249.1998.00746.x","article-title":"Autoantibodies to human melanocyte-specific protein Pmel17 in the sera of vitiligo patients: a sensitive and quantitative radioimmunoassay (RIA)","volume":"114","author":"Kemp","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1046\/j.1365-2249.2002.01949.x","article-title":"Autoantibodies in vitiligo patients are not directed to the melanocyte differentiation antigen MelanA\/MART1","volume":"129","author":"Waterman","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0140-6736(97)11050-9","article-title":"Identification of tryptophan hydroxylase as an intestinal autoantigen","volume":"352","author":"Ekwall","year":"1998","journal-title":"Lancet"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1210\/jc.85.8.2944","article-title":"Pteridin-dependent hydroxylases as autoantigens in autoimmune polyendocrine syndrome type 1","volume":"85","author":"Ekwall","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB35|cit35","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/j.1460-2075.1992.tb05082.x","article-title":"A second tyrosinase-related protein, TRP2, is a melanogenic enzyme termed DOPAchrome tautomerase","volume":"11","author":"Tsukamoto","year":"1992","journal-title":"EMBO J"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/1523-1747.ep12276608","article-title":"Pigmentation-associated glycoprotein of human melanomas and melanocytes: definition with a mouse monoclonal antibody","volume":"85","author":"Thomson","year":"1985","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00008390-199712000-00004","article-title":"Cloning, expression and tissue distribution of the murine homologue of the melanocyte lineage-specific antigen gp100","volume":"7","author":"Schreurs","year":"1997","journal-title":"Melanoma Res"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1034\/j.1600-0625.2003.120108.x","article-title":"Tyrosine hydroxylase isoenzyme I is present in human melanosomes: a possible novel function in pigmentation","volume":"12","author":"Marles","year":"2003","journal-title":"Exp Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0306-9877(95)90302-X","article-title":"Cultured human keratinocytes as a model for studying the dopamine metabolism in schizophrenia","volume":"44","author":"Ramchand","year":"1995","journal-title":"Med Hypotheses"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1600-0749.2004.00153.x","article-title":"Pterin-dependent tyrosine hydroxylase mRNA is not expressed in human melanocytes or melanoma cells","volume":"17","author":"K\u00e5gedal","year":"2004","journal-title":"Pigment Cell Res"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1001\/archderm.117.9.576","article-title":"Immunofluorescence findings in rapid whitening of scalp hair","volume":"117","author":"Guin","year":"1981","journal-title":"Arch Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB43|cit43","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/1523-1747.ep12874660","article-title":"Ultrastructural observations on the hair bulb melanocytes and melanosomes in acute alopecia areata","volume":"94","author":"Tobin","year":"1990","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB44|cit44","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1038\/jid.2009.32","article-title":"Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients","volume":"129","author":"Van den Boorn","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB45|cit45","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/1523-1747.ep12549703","article-title":"Direct immunofluorescence studies in alopecia areata and male pattern alopecia","volume":"73","author":"Bystryn","year":"1979","journal-title":"J Invest Dermtol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"7284","DOI":"10.4049\/jimmunol.151.12.7284","article-title":"A novel, antigen-presenting function of melanocytes and its possible relationship to hypopigmentary disorders","volume":"151","author":"Le Poole","year":"1993","journal-title":"J Immunol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB47|cit47","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1046\/j.1365-2133.1998.02550.x","article-title":"Vitiligo melanocytes in long-term culture show normal constitutive and cytokine-induced expression of intercellular adhesion molecule-1 and major histocompatibility complex class I and class II molecules","volume":"139","author":"Hedley","year":"1998","journal-title":"Br J Dermatol"},{"issue":"Suppl.","key":"10.1111\/j.1365-2133.2011.10597.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1600-0749.1988.tb00801.x","article-title":"Enhanced susceptibility of melanocytes to different immunologic effector mechanisms in vitro: potential mechanisms for post-inflammatory hypopigmentation and vitiligo","volume":"1","author":"Norris","year":"1988","journal-title":"Pigment Cell Res"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB49|cit49","first-page":"587","article-title":"Alopecia areata in children","volume":"17","author":"Ahmed","year":"2007","journal-title":"J Coll Physicians Surg Pak"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB50|cit50","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1111\/j.1468-3083.2006.01676.x","article-title":"Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history","volume":"20","author":"Goh","year":"2006","journal-title":"J Eur Acad Dermatol Venerol"},{"key":"10.1111\/j.1365-2133.2011.10597.x-BIB51|cit51","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1046\/j.1525-1470.1999.00094.x","article-title":"Colocalisation of vitiligo and alopecia areata","volume":"16","author":"Adams","year":"1999","journal-title":"Pediatr Dermatol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2133.2011.10597.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1365-2133.2011.10597.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T05:25:55Z","timestamp":1686288355000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/165\/6\/1236\/6642882"}},"subtitle":["Autoantibodies in alopecia areata"],"short-title":[],"issued":{"date-parts":[[2011,11,17]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2133.2011.10597.x","relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11,17]]}}}