{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:14:21Z","timestamp":1791148461191,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1331,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1111\/j.1365-2133.2011.10646.x","type":"journal-article","created":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T00:52:40Z","timestamp":1316652760000},"page":"266-273","source":"Crossref","is-referenced-by-count":54,"title":["Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata"],"prefix":"10.1093","volume":"166","author":[{"given":"M.","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,1,9]]},"reference":[{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4065\/70.7.628","article-title":"Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989","volume":"70","author":"Safavi","year":"1995","journal-title":"Mayo Clin Proc"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0190-9622(84)70152-6","article-title":"T cell subpopulations in alopecia areata","volume":"11","author":"Todes-Taylor","year":"1984","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/sj.jidsp.5640215","article-title":"Alopecia areata in families: association with the HLA locus","volume":"4","author":"de Andrade","year":"1999","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1046\/j.1365-2230.2002.01077.x","article-title":"Epidemiology and genetics of alopecia areata","volume":"27","author":"McDonagh","year":"2002","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB5|cit5","first-page":"11","article-title":"Genetic susceptibility and severity of alopecia areata in human and animal models","volume":"11","author":"McElwee","year":"2001","journal-title":"Eur J Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1046\/j.1365-2230.2002.01075.x","article-title":"Alopecia areata - animal models","volume":"27","author":"McElwee","year":"2002","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature09114","article-title":"Genome-wide association study in alopecia areata implicates both innate and adaptive immunity","volume":"466","author":"Petukhova","year":"2010","journal-title":"Nature"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1001\/jama.1995.03520420031025","article-title":"Alopecia areata and presence of cytomegalovirus DNA","volume":"273","author":"Skinner","year":"1995","journal-title":"JAMA"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0190-9622(00)90164-6","article-title":"Alopecia areata update","volume":"42","author":"Madani","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0733-8635(05)70368-5","article-title":"Psychophysiology of stress in dermatology. The psychobiologic pattern of psychosomatics","volume":"14","author":"Panconesi","year":"1996","journal-title":"Dermatol Clin"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"J207","DOI":"10.1016\/j.jaut.2009.12.006","article-title":"Epigenetics and autoimmunity","volume":"34","author":"Brooks","year":"2010","journal-title":"J Autoimmun"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.4049\/jimmunol.172.6.3652","article-title":"Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cells","volume":"172","author":"Kaplan","year":"2004","journal-title":"J Immunol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/abbs\/gmq015","article-title":"DNA methyltransferases and methyl-binding proteins of mammals","volume":"42","author":"Lan","year":"2010","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0959-437X(02)00279-4","article-title":"Histone modifications in transcriptional regulation","volume":"12","author":"Berger","year":"2002","journal-title":"Curr Opin Genet Dev"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jaad.2003.09.032","article-title":"Alopecia areata investigational assessment guidelines - Part II. National Alopecia Areata Foundation","volume":"51","author":"Olsen","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2133.2007.07943.x","article-title":"Serum chemokine profiles in patients with alopecia areata","volume":"157","author":"Kuwano","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1521-6616(02)00042-6","article-title":"Transfer of alopecia areata in the human scalp graft\/Prkdc(scid) (SCID) mouse system is characterized by a TH1 response","volume":"106","author":"Gilhar","year":"2003","journal-title":"Clin Immunol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/sj.jidsp.5640212","article-title":"Alopecia areata is a T-lymphocyte mediated autoimmune disease: lesional human T-lymphocytes transfer alopecia areata to human skin grafts on SCID mice","volume":"4","author":"Gilhar","year":"1999","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrrheum.2011.16","article-title":"Epigenetic alterations in autoimmune rheumatic diseases","volume":"7","author":"Ballestar","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/03009740902758875","article-title":"Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis","volume":"38","author":"Lei","year":"2009","journal-title":"Scand J Rheumatol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1365-2133.2008.08758.x","article-title":"Abnormal DNA methylation in T cells from patients with subacute cutaneous lupus erythematosus","volume":"159","author":"Luo","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jdermsci.2010.07.011","article-title":"Abnormal DNA methylation in skin lesions and PBMCs of patients with psoriasis vulgaris","volume":"60","author":"Zhang","year":"2010","journal-title":"J Dermatol Sci"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1365-2133.2010.09919.x","article-title":"Abnormal DNA methylation in peripheral blood mononuclear cells from patients with vitiligo","volume":"163","author":"Zhao","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB24|cit24","first-page":"285","article-title":"Murine models of lupus induced by hypomethylated T cells","volume":"102","author":"Richardson","year":"2004","journal-title":"Methods Mol Med"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0378-4274(99)00220-9","article-title":"Autoimmune diseases associated with drugs, chemicals and environmental factors","volume":"112-113","author":"D\u2019Cruz","year":"2000","journal-title":"Toxicol Lett"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/art.10234","article-title":"Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus","volume":"46","author":"Lu","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jdermsci.2009.06.010","article-title":"DNA demethylation of the perforin promoter in CD4(+) T cells from patients with subacute cutaneous lupus erythematosus","volume":"56","author":"Luo","year":"2009","journal-title":"J Dermatol Sci"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"6538","DOI":"10.1128\/MCB.18.11.6538","article-title":"Identification and characterization of a family of mammalian methyl-CpG binding proteins","volume":"18","author":"Hendrich","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/38664","article-title":"Histone acetylation in chromatin structure and transcription","volume":"389","author":"Grunstein","year":"1997","journal-title":"Nature"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"R546","DOI":"10.1016\/j.cub.2004.07.007","article-title":"Histones and histone modifications","volume":"14","author":"Peterson","year":"2004","journal-title":"Curr Biol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ng.154","article-title":"Combinatorial patterns of histone acetylations and methylations in the human genome","volume":"40","author":"Wang","year":"2008","journal-title":"Nat Genet"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB32|cit32","first-page":"804","article-title":"Abnormal histone modification patterns in lupus CD4+ T cells","volume":"35","author":"Hu","year":"2008","journal-title":"J Rheumatol"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/gene.2010.24","article-title":"DNA methylome in human CD4+ T cells identifies transcriptionally repressive and non-repressive methylation peaks","volume":"11","author":"Hughes","year":"2010","journal-title":"Genes Immun"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"15782","DOI":"10.1073\/pnas.0607617103","article-title":"The genomic landscape of histone modifications in human T cells","volume":"103","author":"Roh","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbagrm.2007.11.006","article-title":"Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression","volume":"1779","author":"Ansari","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/j.1365-2133.2011.10646.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"26771","DOI":"10.1074\/jbc.M802800200","article-title":"Role of the histone H3 lysine 4 methyltransferase, SET7\/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation","volume":"283","author":"Li","year":"2008","journal-title":"J Biol Chem"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2133.2011.10646.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1365-2133.2011.10646.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T08:53:42Z","timestamp":1676364822000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/166\/2\/266\/6613679"}},"subtitle":["Aberrant DNA methylation and histone modifications in AA"],"short-title":[],"issued":{"date-parts":[[2012,1,9]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2133.2011.10646.x","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13669956.15084056","asserted-by":"object"}]},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1,9]]}}}