{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:29:23Z","timestamp":1793766563208,"version":"4.6.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1194,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1111\/j.1365-2133.2012.10885.x","type":"journal-article","created":{"date-parts":[[2012,2,13]],"date-time":"2012-02-13T13:14:06Z","timestamp":1329138846000},"page":"1245-1254","source":"Crossref","is-referenced-by-count":81,"title":["Expression profile of cornified envelope structural proteins and keratinocyte differentiation-regulating proteins during skin barrier repair"],"prefix":"10.1093","volume":"166","author":[{"given":"H.D.","family":"de Koning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.H.","family":"van den Bogaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.G.M.","family":"Bergboer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kamsteeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.M.J.J.","family":"van Vlijmen-Willems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hitomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Takashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ishida-Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schalkwijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.L.J.M.","family":"Zeeuwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,5,25]]},"reference":[{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.7824952","article-title":"Mutations of keratinocyte transglutaminase in lamellar ichthyosis","volume":"267","author":"Huber","year":"1995","journal-title":"Science"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/ng0395-279","article-title":"Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis","volume":"9","author":"Russell","year":"1995","journal-title":"Nat Genet"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/75977","article-title":"Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome","volume":"25","author":"Chavanas","year":"2000","journal-title":"Nat Genet"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s00431-006-0141-0","article-title":"Netherton syndrome: report of identical twins presenting with severe atopic dermatitis","volume":"165","author":"Kilic","year":"2006","journal-title":"Eur J Pediatr"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1542\/pir.15-6-220","article-title":"Atopic dermatitis and ichthyosis vulgaris","volume":"15","author":"Rabinowitz","year":"1994","journal-title":"Pediatr Rev"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1767","article-title":"Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis","volume":"38","author":"Palmer","year":"2006","journal-title":"Nat Genet"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/ng.313","article-title":"Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis","volume":"41","author":"de Cid","year":"2009","journal-title":"Nat Genet"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/ng.2007.48","article-title":"Psoriasis is associated with increased beta-defensin genomic copy number","volume":"40","author":"Hollox","year":"2008","journal-title":"Nat Genet"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/jid.2011.86","article-title":"Deletion of the late cornified envelope genes LCE3C and LCE3B is associated with psoriasis in a Chinese population","volume":"131","author":"Li","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/jid.2010.350","article-title":"Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6","volume":"131","author":"Riveira-Munoz","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jaci.2011.01.053","article-title":"Contrasting pathogenesis of atopic dermatitis and psoriasis - part I: clinical and pathologic concepts","volume":"127","author":"Guttman-Yassky","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMra0804595","article-title":"Psoriasis","volume":"361","author":"Nestle","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/bies.10144","article-title":"Epithelial barrier function: assembly and structural features of the cornified cell envelope","volume":"24","author":"Kalinin","year":"2002","journal-title":"Bioessays"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrm1619","article-title":"The cornified envelope: a model of cell death in the skin","volume":"6","author":"Candi","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/j.0022-202X.2004.22512.x","article-title":"Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE\/KLK5\/hK5 and SCCE\/KLK7\/hK7","volume":"122","author":"Caubet","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrm2636","article-title":"Epidermal homeostasis: a balancing act of stem cells in the skin","volume":"10","author":"Blanpain","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/BF00371571","article-title":"Repeated tape stripping of normal skin: a histological assessment and comparison with events seen in psoriasis","volume":"286","author":"Gerritsen","year":"1994","journal-title":"Arch Dermatol Res"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/sj.jid.5701170","article-title":"Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo","volume":"128","author":"Torma","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1600-0625.2009.00877.x","article-title":"Sodium lauryl sulphate alters the mRNA expression of lipid-metabolizing enzymes and PPAR signalling in normal human skin in vivo","volume":"18","author":"Torma","year":"2009","journal-title":"Exp Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/jid.2010.278","article-title":"Epidermal expression of host response genes upon skin barrier disruption in normal skin and uninvolved skin of psoriasis and atopic dermatitis patients","volume":"131","author":"de Koning","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1006\/geno.2002.6756","article-title":"A partial transcriptome of human epidermis","volume":"79","author":"van Ruissen","year":"2002","journal-title":"Genomics"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.0022-202X.2005.23935.x","article-title":"High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis","volume":"125","author":"de Jongh","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00372711","article-title":"MON-150, a versatile monoclonal antibody against involucrin: characterization and applications","volume":"284","author":"van Duijnhoven","year":"1992","journal-title":"Arch Dermatol Res"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.ajpath.2010.12.017","article-title":"Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups","volume":"178","author":"Bergboer","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"23222","DOI":"10.1074\/jbc.M110.197400","article-title":"Deimination of human filaggrin-2 promotes its proteolysis by calpain 1","volume":"286","author":"Hsu","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1096\/fj.10-168658","article-title":"Hornerin is a component of the epidermal cornified cell envelopes","volume":"25","author":"Henry","year":"2011","journal-title":"FASEB J"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1096\/fj.10-155879","article-title":"The cystatin M\/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea","volume":"24","author":"Zeeuwen","year":"2010","journal-title":"FASEB J"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"34148","DOI":"10.1074\/jbc.274.48.34148","article-title":"Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions in simple epithelial cells","volume":"274","author":"Hiiragi","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.1111\/j.1742-4658.2008.06692.x","article-title":"Identification of preferred substrate sequences for transglutaminase 1 - development of a novel peptide that can efficiently detect cross-linking enzyme activity in the skin","volume":"275","author":"Sugimura","year":"2008","journal-title":"FEBS J"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1600-0625.2010.01170.x","article-title":"Tight junctions in the stratum corneum explain spatial differences in corneodesmosome degradation","volume":"20","author":"Igawa","year":"2011","journal-title":"Exp Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/ng.310","article-title":"Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21","volume":"41","author":"Zhang","year":"2009","journal-title":"Nat Genet"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/1523-1747.ep12582813","article-title":"Stratum corneum structure and function correlates with phenotype in psoriasis","volume":"107","author":"Ghadially","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1172\/JCI21060","article-title":"New insights into atopic dermatitis","volume":"113","author":"Leung","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1172\/JCI200422147","article-title":"Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities","volume":"113","author":"Nickoloff","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1172\/JCI28521","article-title":"Epidermal barrier formation and recovery in skin disorders","volume":"116","author":"Segre","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1365-2230.1990.tb02068.x","article-title":"A functional study of the skin barrier to evaporative water loss by means of repeated cellophane-tape stripping","volume":"15","author":"van der Valk","year":"1990","journal-title":"Clin Exp Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1600-0625.2009.00976.x","article-title":"Large scale study of epidermal recovery after stratum corneum removal: dynamics of genomic response","volume":"19","author":"Sextius","year":"2010","journal-title":"Exp Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-0536.1997.tb00369.x","article-title":"Effect of a topical corticosteroid, a retinoid and a vitamin D3 derivative on sodium dodecyl sulphate induced skin irritation","volume":"37","author":"Le","year":"1997","journal-title":"Contact Dermatitis"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1046\/j.1523-1747.1998.00318.x","article-title":"Expression of epidermal keratins and the cornified envelope protein involucrin is influenced by permeability barrier disruption","volume":"111","author":"Ekanayake-Mudiyanselage","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/jid.2010.307","article-title":"Skin barrier function in healthy subjects and patients with atopic dermatitis in relation to filaggrin loss-of-function mutations","volume":"131","author":"Jakasa","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaci.2007.04.031","article-title":"Cytokine modulation of atopic dermatitis filaggrin skin expression","volume":"120","author":"Howell","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB43|cit43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011957","article-title":"Skin cornification proteins provide global link between ROS detoxification and cell migration during wound healing","volume":"5","author":"Vermeij","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB44|cit44","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2353\/ajpath.2008.070161","article-title":"Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the protease-activated receptor type 2","volume":"172","author":"Demerjian","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB45|cit45","doi-asserted-by":"crossref","first-page":"13693","DOI":"10.1074\/jbc.273.22.13693","article-title":"Transglutaminase 1 mutations in lamellar ichthyosis. Loss of activity due to failure of activation by proteolytic processing","volume":"273","author":"Candi","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"e5227","DOI":"10.1371\/journal.pone.0005227","article-title":"Molecular identification and expression analysis of filaggrin-2, a member of the S100 fused-type protein family","volume":"4","author":"Wu","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB47|cit47","first-page":"226","article-title":"A novel peptide antibiotic derived from human hornerin","volume":"16","author":"Wu","year":"2007","journal-title":"Exp Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1016\/S0006-3495(96)79460-2","article-title":"Homogeneous transport in a heterogeneous membrane: water diffusion across human stratum corneum in vivo","volume":"71","author":"Kalia","year":"1996","journal-title":"Biophys J"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB49|cit49","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/jid.2010.88","article-title":"Deletion of late cornified envelope 3B and 3C genes is not associated with atopic dermatitis","volume":"130","author":"Bergboer","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1111\/j.1365-2133.2012.10885.x-BIB50|cit50","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11882-008-0048-0","article-title":"Skin barrier function","volume":"8","author":"Elias","year":"2008","journal-title":"Curr Allergy Asthma Rep"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2133.2012.10885.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1365-2133.2012.10885.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T08:55:07Z","timestamp":1676364907000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/166\/6\/1245\/6613860"}},"subtitle":["Structural protein expression upon artificial barrier disruption"],"short-title":[],"issued":{"date-parts":[[2012,5,25]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2133.2012.10885.x","relation":{},"ISSN":["0007-0963"],"issn-type":[{"value":"0007-0963","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5,25]]}}}